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Assessment of Transitioning from High-Potency to Low-Potency Inhibitors in Chronic Myeloid Leukemia (CML) Patients: The Downgrading-Impact (D-IMPACT) Project.

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Title: Assessment of Transitioning from High-Potency to Low-Potency Inhibitors in Chronic Myeloid Leukemia (CML) Patients: The Downgrading-Impact (D-IMPACT) Project.
Authors: Abruzzese E; Department of Hematology, S. Eugenio Hospital, Tor Vergata University, ASL Roma 2, 00144 Rome, Italy., Crugnola M; Hematology Unit and BMT, University Hospital of Parma, 43126 Parma, Italy., Garuffo L; Bone Marrow Transplant Unit, Department of Clinical and Experimental Sciences, University of Brescia, ASST Spedali Civili di Brescia, 25123 Brescia, Italy., Markovic U; Hematology and Bone Marrow Transplatation Unit, Azienda Ospedaliero Universitaria Policlinico G. Rodolico-San Marco, 95123 Catania, Italy., Trawinska MM; Department of Hematology, S. Eugenio Hospital, Tor Vergata University, ASL Roma 2, 00144 Rome, Italy., Barulli S; Divisione di Ematologia di Muraglia, CTMO Ospedale San Salvatore, 61121 Pesaro, Italy., Maggi A; Division of Hematology and Bone Marrow Transplant, Ospedale S.G. Moscati, 74010 Taranto, Italy., Galimberti S; Department of Clinical and Experimental Medicine, Hematology, University of Pisa, 56124 Pisa, Italy., Cattaneo D; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milano, Italy., Sannipoli D; San Raffaele Scientific Institute-IRCCS, 20122 Milano, Italy., D'Adda M; S.C. Ematologia, ASST Spedali Civili di Brescia, 25123 Brescia, Italy., Chiara E; IRCCS Fondazione Policlinico San Matteo, 27100 Pavia, Italy., Bonifacio M; Department of Engineering for Innovation Medicine, Section of Innovation Biomedicine, Hematology Area, University of Verona, 37134 Verona, Italy., Russo Rossi AV; Department of Precision and Regenerative Medicine and Ionian Area, 'Aldo Moro' University School of Medicine, 70124 Bari, Italy., Beltrami G; U.O. Ematologia e Terapie Cellulari, IRCCS Azienda Ospedaliera Universitaria San Martino, 16132 Genova, Italy., Russo S; Hematology Section, AOU Policlinico 'G. Martino', University of Messina, 98124 Messina, Italy., Crisà E; Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy., Sanpaolo G; UOC Ematologia e Centro Trapianti Cellule Staminali Emopoietiche, Fondazione IRCCS Casa Sollievo della Sofferenza San Giovanni Rotondo, 71013 San Giovanni Rotondo, Italy., Cavazzini F; Hematology Unit, Arcispedale S. Anna, 44124 Ferrara, Italy., Loglisci G; UO Ematologia, Ospedale Vito Fazzi, 73100 Lecce, Italy., Fava C; Division of Haematology, AO Ordine Mauriziano di Torino, 10128 Turin, Italy.; Department of Clinical and Biological Sciences, University of Turin, 10124 Turin, Italy., Giai V; Division of Hematology, AUO Città della Salute e della Scienza, 10126 Turin, Italy., Scortechini AR; Clinica di Ematologia, Azienda Ospedaliera Universitaria delle Marche, 60126 Ancona, Italy., Scappini B; Hematology Unit, Azienda Ospedaliero-Universitaria Careggi, 50134 Florence, Italy., Dalmazzo M; Internal Medicine and Hematology, S. Luigi Hospital, University of Turin, 10043 Orbassano, Italy., Binotto G; Department of Medicine, Hematology and Clinical Immunology, University of Padua, 35128 Padua, Italy., Bocchia M; Hematology Unit, Azienda Ospedaliera Universitaria Senese, University of Siena, 53100 Siena, Italy., Facchinelli D; Hematology Unit, Ospedale San Bortolo, 36100 Vicenza, Italy., Di Veroli A; UOC Ematologia Ospedale S. Rosa, 01100 Viterbo, Italy., Pascale SP; UOC Ematologia con Trapianto, Azienda Ospedaliera San Carlo, 85100 Potenza, Italy., Leporace A; Azienda Ospedaliera Sant' Andrea Roma, 00189 Rome, Italy., Bernardi S; Bone Marrow Transplant Unit, Department of Clinical and Experimental Sciences, University of Brescia, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
Source: Cancers [Cancers (Basel)] 2026 May 20; Vol. 18 (10). Date of Electronic Publication: 2026 May 20.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Assessment of Transitioning from High-Potency to Low-Potency Inhibitors in Chronic Myeloid Leukemia (CML) Patients: The Downgrading-Impact (D-IMPACT) Project.
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  Data: <searchLink fieldCode="AU" term="%22Abruzzese+E%22">Abruzzese E</searchLink>; Department of Hematology, S. Eugenio Hospital, Tor Vergata University, ASL Roma 2, 00144 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Crugnola+M%22">Crugnola M</searchLink>; Hematology Unit and BMT, University Hospital of Parma, 43126 Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Garuffo+L%22">Garuffo L</searchLink>; Bone Marrow Transplant Unit, Department of Clinical and Experimental Sciences, University of Brescia, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Markovic+U%22">Markovic U</searchLink>; Hematology and Bone Marrow Transplatation Unit, Azienda Ospedaliero Universitaria Policlinico G. Rodolico-San Marco, 95123 Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Trawinska+MM%22">Trawinska MM</searchLink>; Department of Hematology, S. Eugenio Hospital, Tor Vergata University, ASL Roma 2, 00144 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Barulli+S%22">Barulli S</searchLink>; Divisione di Ematologia di Muraglia, CTMO Ospedale San Salvatore, 61121 Pesaro, Italy.<br /><searchLink fieldCode="AU" term="%22Maggi+A%22">Maggi A</searchLink>; Division of Hematology and Bone Marrow Transplant, Ospedale S.G. Moscati, 74010 Taranto, Italy.<br /><searchLink fieldCode="AU" term="%22Galimberti+S%22">Galimberti S</searchLink>; Department of Clinical and Experimental Medicine, Hematology, University of Pisa, 56124 Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Cattaneo+D%22">Cattaneo D</searchLink>; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Sannipoli+D%22">Sannipoli D</searchLink>; San Raffaele Scientific Institute-IRCCS, 20122 Milano, Italy.<br /><searchLink fieldCode="AU" term="%22D'Adda+M%22">D'Adda M</searchLink>; S.C. Ematologia, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Chiara+E%22">Chiara E</searchLink>; IRCCS Fondazione Policlinico San Matteo, 27100 Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Bonifacio+M%22">Bonifacio M</searchLink>; Department of Engineering for Innovation Medicine, Section of Innovation Biomedicine, Hematology Area, University of Verona, 37134 Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Russo+Rossi+AV%22">Russo Rossi AV</searchLink>; Department of Precision and Regenerative Medicine and Ionian Area, 'Aldo Moro' University School of Medicine, 70124 Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Beltrami+G%22">Beltrami G</searchLink>; U.O. Ematologia e Terapie Cellulari, IRCCS Azienda Ospedaliera Universitaria San Martino, 16132 Genova, Italy.<br /><searchLink fieldCode="AU" term="%22Russo+S%22">Russo S</searchLink>; Hematology Section, AOU Policlinico 'G. Martino', University of Messina, 98124 Messina, Italy.<br /><searchLink fieldCode="AU" term="%22Crisà+E%22">Crisà E</searchLink>; Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Sanpaolo+G%22">Sanpaolo G</searchLink>; UOC Ematologia e Centro Trapianti Cellule Staminali Emopoietiche, Fondazione IRCCS Casa Sollievo della Sofferenza San Giovanni Rotondo, 71013 San Giovanni Rotondo, Italy.<br /><searchLink fieldCode="AU" term="%22Cavazzini+F%22">Cavazzini F</searchLink>; Hematology Unit, Arcispedale S. Anna, 44124 Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Loglisci+G%22">Loglisci G</searchLink>; UO Ematologia, Ospedale Vito Fazzi, 73100 Lecce, Italy.<br /><searchLink fieldCode="AU" term="%22Fava+C%22">Fava C</searchLink>; Division of Haematology, AO Ordine Mauriziano di Torino, 10128 Turin, Italy.; Department of Clinical and Biological Sciences, University of Turin, 10124 Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Giai+V%22">Giai V</searchLink>; Division of Hematology, AUO Città della Salute e della Scienza, 10126 Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Scortechini+AR%22">Scortechini AR</searchLink>; Clinica di Ematologia, Azienda Ospedaliera Universitaria delle Marche, 60126 Ancona, Italy.<br /><searchLink fieldCode="AU" term="%22Scappini+B%22">Scappini B</searchLink>; Hematology Unit, Azienda Ospedaliero-Universitaria Careggi, 50134 Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Dalmazzo+M%22">Dalmazzo M</searchLink>; Internal Medicine and Hematology, S. Luigi Hospital, University of Turin, 10043 Orbassano, Italy.<br /><searchLink fieldCode="AU" term="%22Binotto+G%22">Binotto G</searchLink>; Department of Medicine, Hematology and Clinical Immunology, University of Padua, 35128 Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Bocchia+M%22">Bocchia M</searchLink>; Hematology Unit, Azienda Ospedaliera Universitaria Senese, University of Siena, 53100 Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Facchinelli+D%22">Facchinelli D</searchLink>; Hematology Unit, Ospedale San Bortolo, 36100 Vicenza, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Veroli+A%22">Di Veroli A</searchLink>; UOC Ematologia Ospedale S. Rosa, 01100 Viterbo, Italy.<br /><searchLink fieldCode="AU" term="%22Pascale+SP%22">Pascale SP</searchLink>; UOC Ematologia con Trapianto, Azienda Ospedaliera San Carlo, 85100 Potenza, Italy.<br /><searchLink fieldCode="AU" term="%22Leporace+A%22">Leporace A</searchLink>; Azienda Ospedaliera Sant' Andrea Roma, 00189 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Bernardi+S%22">Bernardi S</searchLink>; Bone Marrow Transplant Unit, Department of Clinical and Experimental Sciences, University of Brescia, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
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  Data: <searchLink fieldCode="JN" term="%22101526829%22">Cancers</searchLink> [Cancers (Basel)] 2026 May 20; Vol. 18 (10). <i>Date of Electronic Publication: </i>2026 May 20.
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