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Mechanical Stiffening Promotes Growth, Invasion-Associated Phenotypes, and Reduced Selumetinib Sensitivity in 3D Plexiform Neurofibroma Cultures.

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Title: Mechanical Stiffening Promotes Growth, Invasion-Associated Phenotypes, and Reduced Selumetinib Sensitivity in 3D Plexiform Neurofibroma Cultures.
Authors: Ji K; Department of Neurology, Henry Ford Health System, Detroit, MI 48202, USA.; Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA.; Department of Physiology, Michigan State University, East Lansing, MI 48824, USA., Shi C; Department of Biomedical Engineering, Michigan State University, East Lansing, MI 48823, USA., Zhang J; Department of Biomedical Engineering, Michigan State University, East Lansing, MI 48823, USA., Mattingly RR; Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA.; Department of Pharmacology and Toxicology, East Carolina University Brody Medical School, Greenville, NC 27834, USA.
Source: Cells [Cells] 2026 May 12; Vol. 15 (10). Date of Electronic Publication: 2026 May 12.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mechanical Stiffening Promotes Growth, Invasion-Associated Phenotypes, and Reduced Selumetinib Sensitivity in 3D Plexiform Neurofibroma Cultures.
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  Data: <searchLink fieldCode="AU" term="%22Ji+K%22">Ji K</searchLink>; Department of Neurology, Henry Ford Health System, Detroit, MI 48202, USA.; Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA.; Department of Physiology, Michigan State University, East Lansing, MI 48824, USA.<br /><searchLink fieldCode="AU" term="%22Shi+C%22">Shi C</searchLink>; Department of Biomedical Engineering, Michigan State University, East Lansing, MI 48823, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Biomedical Engineering, Michigan State University, East Lansing, MI 48823, USA.<br /><searchLink fieldCode="AU" term="%22Mattingly+RR%22">Mattingly RR</searchLink>; Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA.; Department of Pharmacology and Toxicology, East Carolina University Brody Medical School, Greenville, NC 27834, USA.
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        Value: 10.3390/cells15100877
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        Text: English
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      – TitleFull: Mechanical Stiffening Promotes Growth, Invasion-Associated Phenotypes, and Reduced Selumetinib Sensitivity in 3D Plexiform Neurofibroma Cultures.
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            NameFull: Shi C
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            NameFull: Zhang J
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            – D: 12
              M: 05
              Text: 2026 May 12
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              Y: 2026
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