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Blood Focused-Metabolomics and Transcriptomics Uncover Non-Linear Risk Association of Inadequate Dietary Choline Intake-Linked Metabolic Stress with MASLD Through Amino Acid Biomarkers, BCAA and MTORC 1/AKT1/IRS1 Mechanistic Mediators: A Nested Case-Control Study.

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Title: Blood Focused-Metabolomics and Transcriptomics Uncover Non-Linear Risk Association of Inadequate Dietary Choline Intake-Linked Metabolic Stress with MASLD Through Amino Acid Biomarkers, BCAA and MTORC 1/AKT1/IRS1 Mechanistic Mediators: A Nested Case-Control Study.
Authors: Wu CH; Ph.D. Program in Nutrition and Food Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.; Department of Gastroenterology and Hepatology, Taipei Hospital, Ministry of Health and Welfare, New Taipei City 242033, Taiwan.; Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan., Lin ML; Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.; Department of Biomedical Engineering, Dayeh University, Changhua City 51591, Taiwan., Wang CY; Ph.D. Program in Nutrition and Food Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan., Chang CY; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Fu Jen Catholic University Hospital, New Taipei City 242062, Taiwan., Lee FJ; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Fu Jen Catholic University Hospital, New Taipei City 242062, Taiwan., Cheng ML; Metabolomics Core Laboratory, Healthy Aging Research Center, Chang Gung University, Taoyuan 33302, Taiwan., Lin YS; Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.; Department of Nutrition, China Medical University, Taichung City 406040, Taiwan., Chen TW; Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan., Hsiao YT; Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan., Wang BW; Ph.D. Program in Nutrition and Food Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.; Department of Nutrition, Fu Jen Catholic University Hospital, New Taipei City 243089, Taiwan., Kuo CS; Department of Nutrition, Fu Jen Catholic University Hospital, New Taipei City 243089, Taiwan., Huang RS; Ph.D. Program in Nutrition and Food Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.; Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.
Source: International journal of molecular sciences [Int J Mol Sci] 2026 May 08; Vol. 27 (10). Date of Electronic Publication: 2026 May 08.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Blood Focused-Metabolomics and Transcriptomics Uncover Non-Linear Risk Association of Inadequate Dietary Choline Intake-Linked Metabolic Stress with MASLD Through Amino Acid Biomarkers, BCAA and MTORC 1/AKT1/IRS1 Mechanistic Mediators: A Nested Case-Control Study.
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  Data: <searchLink fieldCode="AU" term="%22Wu+CH%22">Wu CH</searchLink>; Ph.D. Program in Nutrition and Food Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.; Department of Gastroenterology and Hepatology, Taipei Hospital, Ministry of Health and Welfare, New Taipei City 242033, Taiwan.; Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+ML%22">Lin ML</searchLink>; Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.; Department of Biomedical Engineering, Dayeh University, Changhua City 51591, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+CY%22">Wang CY</searchLink>; Ph.D. Program in Nutrition and Food Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+CY%22">Chang CY</searchLink>; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Fu Jen Catholic University Hospital, New Taipei City 242062, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+FJ%22">Lee FJ</searchLink>; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Fu Jen Catholic University Hospital, New Taipei City 242062, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cheng+ML%22">Cheng ML</searchLink>; Metabolomics Core Laboratory, Healthy Aging Research Center, Chang Gung University, Taoyuan 33302, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+YS%22">Lin YS</searchLink>; Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.; Department of Nutrition, China Medical University, Taichung City 406040, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+TW%22">Chen TW</searchLink>; Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsiao+YT%22">Hsiao YT</searchLink>; Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+BW%22">Wang BW</searchLink>; Ph.D. Program in Nutrition and Food Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.; Department of Nutrition, Fu Jen Catholic University Hospital, New Taipei City 243089, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kuo+CS%22">Kuo CS</searchLink>; Department of Nutrition, Fu Jen Catholic University Hospital, New Taipei City 243089, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+RS%22">Huang RS</searchLink>; Ph.D. Program in Nutrition and Food Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.; Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%22101092791%22">International journal of molecular sciences</searchLink> [Int J Mol Sci] 2026 May 08; Vol. 27 (10). <i>Date of Electronic Publication: </i>2026 May 08.
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              Text: 2026 May 08
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