Computational Analysis of SPI1 Missense Mutations and ADMET-Guided Molecular Docking of Cinnamic Acid Targeting the PU.1 ETS Domain: Implications for Hematopoietic Dysregulation and Leukemogenesis.

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Title: Computational Analysis of SPI1 Missense Mutations and ADMET-Guided Molecular Docking of Cinnamic Acid Targeting the PU.1 ETS Domain: Implications for Hematopoietic Dysregulation and Leukemogenesis.
Authors: Jaddah MM; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taibah University, Al Madinah Al Munawarah 42353, Saudi Arabia., Khalaf SN; Department of Biotechnology, College of Science, University of Anbar, Ramadi 31001, Iraq., Ahmed MM; Department of Biotechnology, College of Science, University of Anbar, Ramadi 31001, Iraq., Alshanqiti AA; Department of Physiology, College of Medicine, Umm Al-Qura University, P.O. Box 715, Makkah 24382, Saudi Arabia.
Source: International journal of molecular sciences [Int J Mol Sci] 2026 May 11; Vol. 27 (10). Date of Electronic Publication: 2026 May 11.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Jaddah+MM%22">Jaddah MM</searchLink>; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taibah University, Al Madinah Al Munawarah 42353, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Khalaf+SN%22">Khalaf SN</searchLink>; Department of Biotechnology, College of Science, University of Anbar, Ramadi 31001, Iraq.<br /><searchLink fieldCode="AU" term="%22Ahmed+MM%22">Ahmed MM</searchLink>; Department of Biotechnology, College of Science, University of Anbar, Ramadi 31001, Iraq.<br /><searchLink fieldCode="AU" term="%22Alshanqiti+AA%22">Alshanqiti AA</searchLink>; Department of Physiology, College of Medicine, Umm Al-Qura University, P.O. Box 715, Makkah 24382, Saudi Arabia.
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  Data: <searchLink fieldCode="JN" term="%22101092791%22">International journal of molecular sciences</searchLink> [Int J Mol Sci] 2026 May 11; Vol. 27 (10). <i>Date of Electronic Publication: </i>2026 May 11.
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        Value: 10.3390/ijms27104278
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        Text: English
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      – TitleFull: Computational Analysis of SPI1 Missense Mutations and ADMET-Guided Molecular Docking of Cinnamic Acid Targeting the PU.1 ETS Domain: Implications for Hematopoietic Dysregulation and Leukemogenesis.
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              Text: 2026 May 11
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