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Optimization of a parallel CAR for B-cell lymphoma via ITAM attenuation and target specificity validation.

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Title: Optimization of a parallel CAR for B-cell lymphoma via ITAM attenuation and target specificity validation.
Authors: Kausar F; Leucid Bio Ltd., Guy's Hospital, Great Maze Pond, London SE1 9RT, UK., Davis C; Leucid Bio Ltd., Guy's Hospital, Great Maze Pond, London SE1 9RT, UK., Larcombe-Young D; Leucid Bio Ltd., Guy's Hospital, Great Maze Pond, London SE1 9RT, UK.; King's College London, CAR Mechanics Group, Department of Precision & Population Oncology, School of Cancer and Pharmaceutical Sciences, London SE1 9RT, UK., Bove C; Leucid Bio Ltd., Guy's Hospital, Great Maze Pond, London SE1 9RT, UK., Farzaneh F; King's College London, Department of Haematology, School of Cancer and Pharmaceutical Sciences, London SE5 9RS, UK.; ViroCell Biologics, Zayed Centre for Research into Rare Diseases in Children, London WC1N 1DZ, UK., Graham C; King's College London, Department of Haematology, School of Cancer and Pharmaceutical Sciences, London SE5 9RS, UK.; King's College Hospital, Department of Haematology, London SE5 9RS, UK., Benjamin R; King's College London, Department of Haematology, School of Cancer and Pharmaceutical Sciences, London SE5 9RS, UK.; King's College Hospital, Department of Haematology, London SE5 9RS, UK., Davies DM; Leucid Bio Ltd., Guy's Hospital, Great Maze Pond, London SE1 9RT, UK., Maher J; Leucid Bio Ltd., Guy's Hospital, Great Maze Pond, London SE1 9RT, UK.; King's College London, CAR Mechanics Group, Department of Precision & Population Oncology, School of Cancer and Pharmaceutical Sciences, London SE1 9RT, UK.; Department of Immunology, Eastbourne Hospital, Kings Drive, Eastbourne, East Sussex BN21 2UD, UK.
Source: Clinical and experimental immunology [Clin Exp Immunol] 2026 Jan 06; Vol. 220 (1).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0057202 Publication Model: Print Cited Medium: Internet ISSN: 1365-2249 (Electronic) Linking ISSN: 00099104 NLM ISO Abbreviation: Clin Exp Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Optimization of a parallel CAR for B-cell lymphoma via ITAM attenuation and target specificity validation.
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  Data: <searchLink fieldCode="AU" term="%22Kausar+F%22">Kausar F</searchLink>; Leucid Bio Ltd., Guy's Hospital, Great Maze Pond, London SE1 9RT, UK.<br /><searchLink fieldCode="AU" term="%22Davis+C%22">Davis C</searchLink>; Leucid Bio Ltd., Guy's Hospital, Great Maze Pond, London SE1 9RT, UK.<br /><searchLink fieldCode="AU" term="%22Larcombe-Young+D%22">Larcombe-Young D</searchLink>; Leucid Bio Ltd., Guy's Hospital, Great Maze Pond, London SE1 9RT, UK.; King's College London, CAR Mechanics Group, Department of Precision & Population Oncology, School of Cancer and Pharmaceutical Sciences, London SE1 9RT, UK.<br /><searchLink fieldCode="AU" term="%22Bove+C%22">Bove C</searchLink>; Leucid Bio Ltd., Guy's Hospital, Great Maze Pond, London SE1 9RT, UK.<br /><searchLink fieldCode="AU" term="%22Farzaneh+F%22">Farzaneh F</searchLink>; King's College London, Department of Haematology, School of Cancer and Pharmaceutical Sciences, London SE5 9RS, UK.; ViroCell Biologics, Zayed Centre for Research into Rare Diseases in Children, London WC1N 1DZ, UK.<br /><searchLink fieldCode="AU" term="%22Graham+C%22">Graham C</searchLink>; King's College London, Department of Haematology, School of Cancer and Pharmaceutical Sciences, London SE5 9RS, UK.; King's College Hospital, Department of Haematology, London SE5 9RS, UK.<br /><searchLink fieldCode="AU" term="%22Benjamin+R%22">Benjamin R</searchLink>; King's College London, Department of Haematology, School of Cancer and Pharmaceutical Sciences, London SE5 9RS, UK.; King's College Hospital, Department of Haematology, London SE5 9RS, UK.<br /><searchLink fieldCode="AU" term="%22Davies+DM%22">Davies DM</searchLink>; Leucid Bio Ltd., Guy's Hospital, Great Maze Pond, London SE1 9RT, UK.<br /><searchLink fieldCode="AU" term="%22Maher+J%22">Maher J</searchLink>; Leucid Bio Ltd., Guy's Hospital, Great Maze Pond, London SE1 9RT, UK.; King's College London, CAR Mechanics Group, Department of Precision & Population Oncology, School of Cancer and Pharmaceutical Sciences, London SE1 9RT, UK.; Department of Immunology, Eastbourne Hospital, Kings Drive, Eastbourne, East Sussex BN21 2UD, UK.
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  Data: <searchLink fieldCode="JN" term="%220057202%22">Clinical and experimental immunology</searchLink> [Clin Exp Immunol] 2026 Jan 06; Vol. 220 (1).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0057202 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1365-2249 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200099104%22">00099104 </searchLink><i>NLM ISO Abbreviation: </i>Clin Exp Immunol <i>Subsets: </i>MEDLINE
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        Value: 10.1093/cei/uxag032
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        Text: English
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              Text: 2026 Jan 06
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