Is There a Unified Etiology of Hypoplastic Left Heart Syndrome? Evaluating Genetic, Structural, and Hemodynamic Models of Disease Initiation.

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Title: Is There a Unified Etiology of Hypoplastic Left Heart Syndrome? Evaluating Genetic, Structural, and Hemodynamic Models of Disease Initiation.
Authors: Leonhard R; Congenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA.; Louisiana State University Health Sciences Center at Shreveport, School of Medicine, 1501 Kings Highway, Shreveport, LA 71103, USA., Phillips ZB; Congenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA.; Louisiana State University Health Sciences Center at Shreveport, School of Medicine, 1501 Kings Highway, Shreveport, LA 71103, USA., Wilson J; Congenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA., Abu-Mowis Z; Congenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA., DiGiorgi J; Congenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA., Wilson EN; Congenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA., Borenstein Z; Congenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA., Wilson L; Congenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA., Tang R; Pediatric Cardiac Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA., Stephens EH; Department of Cardiovascular Surgery, Mayo Clinic, Rochester, MN 55905, USA., Crucean A; Department of Paediatric Cardiac Surgery, Birmingham Women's and Children's Hospital, Birmingham B4 6N4, UK., Shillingford MS; Congenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA., Peek GJ; Congenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA., Bleiweis MS; Congenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA., Alexander JS; Louisiana State University Health Sciences Center at Shreveport, School of Medicine, 1501 Kings Highway, Shreveport, LA 71103, USA., Jacobs JP; Congenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA.
Source: Pathophysiology : the official journal of the International Society for Pathophysiology [Pathophysiology] 2026 May 20; Vol. 33 (2). Date of Electronic Publication: 2026 May 20.
Publication Type: Journal Article; Review
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 9433813 Publication Model: Electronic Cited Medium: Internet ISSN: 1873-149X (Electronic) Linking ISSN: 09284680 NLM ISO Abbreviation: Pathophysiology Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Is There a Unified Etiology of Hypoplastic Left Heart Syndrome? Evaluating Genetic, Structural, and Hemodynamic Models of Disease Initiation.
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  Data: <searchLink fieldCode="AU" term="%22Leonhard+R%22">Leonhard R</searchLink>; Congenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA.; Louisiana State University Health Sciences Center at Shreveport, School of Medicine, 1501 Kings Highway, Shreveport, LA 71103, USA.<br /><searchLink fieldCode="AU" term="%22Phillips+ZB%22">Phillips ZB</searchLink>; Congenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA.; Louisiana State University Health Sciences Center at Shreveport, School of Medicine, 1501 Kings Highway, Shreveport, LA 71103, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+J%22">Wilson J</searchLink>; Congenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA.<br /><searchLink fieldCode="AU" term="%22Abu-Mowis+Z%22">Abu-Mowis Z</searchLink>; Congenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA.<br /><searchLink fieldCode="AU" term="%22DiGiorgi+J%22">DiGiorgi J</searchLink>; Congenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+EN%22">Wilson EN</searchLink>; Congenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA.<br /><searchLink fieldCode="AU" term="%22Borenstein+Z%22">Borenstein Z</searchLink>; Congenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+L%22">Wilson L</searchLink>; Congenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA.<br /><searchLink fieldCode="AU" term="%22Tang+R%22">Tang R</searchLink>; Pediatric Cardiac Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Stephens+EH%22">Stephens EH</searchLink>; Department of Cardiovascular Surgery, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Crucean+A%22">Crucean A</searchLink>; Department of Paediatric Cardiac Surgery, Birmingham Women's and Children's Hospital, Birmingham B4 6N4, UK.<br /><searchLink fieldCode="AU" term="%22Shillingford+MS%22">Shillingford MS</searchLink>; Congenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA.<br /><searchLink fieldCode="AU" term="%22Peek+GJ%22">Peek GJ</searchLink>; Congenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA.<br /><searchLink fieldCode="AU" term="%22Bleiweis+MS%22">Bleiweis MS</searchLink>; Congenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA.<br /><searchLink fieldCode="AU" term="%22Alexander+JS%22">Alexander JS</searchLink>; Louisiana State University Health Sciences Center at Shreveport, School of Medicine, 1501 Kings Highway, Shreveport, LA 71103, USA.<br /><searchLink fieldCode="AU" term="%22Jacobs+JP%22">Jacobs JP</searchLink>; Congenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA.
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