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Multicellular senescence impairs skeletal muscle recovery following disuse in aging.

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Title: Multicellular senescence impairs skeletal muscle recovery following disuse in aging.
Authors: Bourrant PE; Department of Nutrition and Integrative Physiology, University of Utah, 250 South 1850 East, Salt Lake City, UT 84112, USA., Yee EM; Department of Nutrition and Integrative Physiology, University of Utah, 250 South 1850 East, Salt Lake City, UT 84112, USA., Fennel ZJ; Department of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA., Castro RJ; Department of Nutrition and Integrative Physiology, University of Utah, 250 South 1850 East, Salt Lake City, UT 84112, USA., Skiles CM; Department of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA., Petrocelli JJ; Department of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA., de Hart NMMP; Department of Nutrition and Integrative Physiology, University of Utah, 250 South 1850 East, Salt Lake City, UT 84112, USA., Lesniewski LA; Department of Internal Medicine, Division of Geriatrics, University of Utah, 30 North Mario Capecchi Dr, 2nd Floor North, Salt Lake City, Utah 84112, USA.; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, 95 South 2000 East, Bldg. 500, Salt Lake City, UT 84112-5000, USA., Beaudin AE; Departments of Pathology and Internal Medicine and Program in Molecular Medicine, University of Utah, Salt Lake City, UT 84112, USA., Funai K; Department of Nutrition and Integrative Physiology, University of Utah, 250 South 1850 East, Salt Lake City, UT 84112, USA., Fry CS; Center for Muscle Biology, University of Kentucky, Lexington, KY 40536-0200, USA., Drummond MJ; Department of Nutrition and Integrative Physiology, University of Utah, 250 South 1850 East, Salt Lake City, UT 84112, USA.; Department of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA.
Source: Science advances [Sci Adv] 2026 May 29; Vol. 12 (22), pp. eaed5255. Date of Electronic Publication: 2026 May 27.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Bourrant+PE%22">Bourrant PE</searchLink>; Department of Nutrition and Integrative Physiology, University of Utah, 250 South 1850 East, Salt Lake City, UT 84112, USA.<br /><searchLink fieldCode="AU" term="%22Yee+EM%22">Yee EM</searchLink>; Department of Nutrition and Integrative Physiology, University of Utah, 250 South 1850 East, Salt Lake City, UT 84112, USA.<br /><searchLink fieldCode="AU" term="%22Fennel+ZJ%22">Fennel ZJ</searchLink>; Department of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA.<br /><searchLink fieldCode="AU" term="%22Castro+RJ%22">Castro RJ</searchLink>; Department of Nutrition and Integrative Physiology, University of Utah, 250 South 1850 East, Salt Lake City, UT 84112, USA.<br /><searchLink fieldCode="AU" term="%22Skiles+CM%22">Skiles CM</searchLink>; Department of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA.<br /><searchLink fieldCode="AU" term="%22Petrocelli+JJ%22">Petrocelli JJ</searchLink>; Department of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA.<br /><searchLink fieldCode="AU" term="%22de+Hart+NMMP%22">de Hart NMMP</searchLink>; Department of Nutrition and Integrative Physiology, University of Utah, 250 South 1850 East, Salt Lake City, UT 84112, USA.<br /><searchLink fieldCode="AU" term="%22Lesniewski+LA%22">Lesniewski LA</searchLink>; Department of Internal Medicine, Division of Geriatrics, University of Utah, 30 North Mario Capecchi Dr, 2nd Floor North, Salt Lake City, Utah 84112, USA.; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, 95 South 2000 East, Bldg. 500, Salt Lake City, UT 84112-5000, USA.<br /><searchLink fieldCode="AU" term="%22Beaudin+AE%22">Beaudin AE</searchLink>; Departments of Pathology and Internal Medicine and Program in Molecular Medicine, University of Utah, Salt Lake City, UT 84112, USA.<br /><searchLink fieldCode="AU" term="%22Funai+K%22">Funai K</searchLink>; Department of Nutrition and Integrative Physiology, University of Utah, 250 South 1850 East, Salt Lake City, UT 84112, USA.<br /><searchLink fieldCode="AU" term="%22Fry+CS%22">Fry CS</searchLink>; Center for Muscle Biology, University of Kentucky, Lexington, KY 40536-0200, USA.<br /><searchLink fieldCode="AU" term="%22Drummond+MJ%22">Drummond MJ</searchLink>; Department of Nutrition and Integrative Physiology, University of Utah, 250 South 1850 East, Salt Lake City, UT 84112, USA.; Department of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA.
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  Data: <searchLink fieldCode="JN" term="%22101653440%22">Science advances</searchLink> [Sci Adv] 2026 May 29; Vol. 12 (22), pp. eaed5255. <i>Date of Electronic Publication: </i>2026 May 27.
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