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Time to HIV rebound after infusion of long-acting broadly neutralising antibodies 3BNC117-LS and 10-1074-LS and analytical treatment interruption (the RIO trial): a double-blind, randomised, placebo-controlled trial.

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Title: Time to HIV rebound after infusion of long-acting broadly neutralising antibodies 3BNC117-LS and 10-1074-LS and analytical treatment interruption (the RIO trial): a double-blind, randomised, placebo-controlled trial.
Authors: Lee MJ; Department of Infectious Disease, and Imperial Clinical Trials Unit, School of Public Health, Faculty of Medicine, Imperial College London, London, UK; Imperial College Healthcare NHS Trust, London, UK., Cherrill LR; Department of Infectious Disease, and Imperial Clinical Trials Unit, School of Public Health, Faculty of Medicine, Imperial College London, London, UK., Zacharopoulou P; Nuffield Department of Medicine, University of Oxford, London, UK., Collins S; HIV i-Base, London, UK., Fumagalli M; The Rockefeller University, New York, NY, USA., Falaschetti E; Department of Infectious Disease, and Imperial Clinical Trials Unit, School of Public Health, Faculty of Medicine, Imperial College London, London, UK., Altaf M; Nuffield Department of Medicine, University of Oxford, London, UK., Tipoe T; Nuffield Department of Medicine, University of Oxford, London, UK; Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong., Godakandaarachi P; Guy's and St Thomas' Hospital NHS Foundation Trust, London, UK., Fox J; Guy's and St Thomas' Hospital NHS Foundation Trust, London, UK., Uriel A; Manchester University NHS Foundation Trust, Manchester, UK., Clarke A; University Hospitals Sussex NHS Foundation Trust and Brighton & Sussex Medical School, Brighton, UK., Loes SK; Royal Free London NHS Foundation Trust, London, UK; University College London, London, UK., Pett S; University College London, London, UK; Central and North West London NHS Foundation Trust, London, UK., Boffito M; Chelsea and Westminster Hospital, London, UK., Whitlock G; Chelsea and Westminster Hospital, London, UK., Søgaard OS; Aarhus University and Aarhus University Hospital, Aarhus, Denmark., Ring K; Queen Mary University of London and Barts Health NHS Trust, London, UK., Mangawa I; Manchester University NHS Foundation Trust, Manchester, UK., Gohil J; Department of Infectious Disease, and Imperial Clinical Trials Unit, School of Public Health, Faculty of Medicine, Imperial College London, London, UK; Imperial College Healthcare NHS Trust, London, UK., Elliott T; Department of Infectious Disease, and Imperial Clinical Trials Unit, School of Public Health, Faculty of Medicine, Imperial College London, London, UK; Imperial College Healthcare NHS Trust, London, UK; National Institute for Health Research, Imperial Biomedical Research Centre, London, UK., Nielsen H; Aalborg University and Aalborg University Hospital, Aalborg, Denmark., Gunst JD; Aarhus University and Aarhus University Hospital, Aarhus, Denmark., Orkin C; Queen Mary University of London and Barts Health NHS Trust, London, UK., Sutherland R; Western General Hospital, NHS Lothian Trust, Edinburgh, UK., Hamzah L; St George's University Hospitals, NHS Foundation Trust, London, UK., Cicconi P; Nuffield Department of Medicine, University of Oxford, London, UK; Centre for Clinical Vaccinology and Tropical Medicine and the Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Taylor GP; Department of Infectious Disease, and Imperial Clinical Trials Unit, School of Public Health, Faculty of Medicine, Imperial College London, London, UK., Ujetz J; Department of Infectious Disease, and Imperial Clinical Trials Unit, School of Public Health, Faculty of Medicine, Imperial College London, London, UK., Jahan I; Department of Infectious Disease, and Imperial Clinical Trials Unit, School of Public Health, Faculty of Medicine, Imperial College London, London, UK., Brown H; Nuffield Department of Medicine, University of Oxford, London, UK., Robinson N; Nuffield Department of Medicine, University of Oxford, London, UK., Fletcher S; Department of Infectious Disease, and Imperial Clinical Trials Unit, School of Public Health, Faculty of Medicine, Imperial College London, London, UK., Box H; Department of Infectious Disease, and Imperial Clinical Trials Unit, School of Public Health, Faculty of Medicine, Imperial College London, London, UK; National Institute for Health Research, Imperial Biomedical Research Centre, London, UK., Seaton KE; Duke University, Durham, NC, USA., Tomaras GD; Duke University, Durham, NC, USA., Ackerman ME; Dartmouth College, Hanover, NH, USA., Weiner JA; Dartmouth College, Hanover, NH, USA., Kaczynska A; The Rockefeller University, New York, NY, USA., Bittar C; The Rockefeller University, New York, NY, USA., Horowitz J; The Rockefeller University, New York, NY, USA., Nussenzweig MC; The Rockefeller University, New York, NY, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Caskey M; The Rockefeller University, New York, NY, USA., Frater J; Nuffield Department of Medicine, University of Oxford, London, UK; National Institute for Health Research, Oxford Biomedical Research Centre, Oxford, UK., Fidler S; Department of Infectious Disease, and Imperial Clinical Trials Unit, School of Public Health, Faculty of Medicine, Imperial College London, London, UK; Imperial College Healthcare NHS Trust, London, UK; National Institute for Health Research, Imperial Biomedical Research Centre, London, UK. Electronic address: s.fidler@imperial.ac.uk.
Corporate Authors: RIO Study Team
Source: The lancet. HIV [Lancet HIV] 2026 Aug; Vol. 13 (8), pp. e527-e537. Date of Electronic Publication: 2026 May 27.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101645355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3018 (Electronic) Linking ISSN: 23523018 NLM ISO Abbreviation: Lancet HIV Subsets: MEDLINE
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  Data: Time to HIV rebound after infusion of long-acting broadly neutralising antibodies 3BNC117-LS and 10-1074-LS and analytical treatment interruption (the RIO trial): a double-blind, randomised, placebo-controlled trial.
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