Adjuvant chemoradiotherapy versus completion total mesorectal excision after local excision for early rectal cancer (TESAR): a multicentre, randomised, controlled, phase 3, non-inferiority trial.
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| Title: | Adjuvant chemoradiotherapy versus completion total mesorectal excision after local excision for early rectal cancer (TESAR): a multicentre, randomised, controlled, phase 3, non-inferiority trial. |
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| Authors: | Moolenaar LR; Department of Surgery, Amsterdam University Medical Center, Amsterdam, Netherlands; Treatment and Quality of Life and Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands., Ali M; Department of Surgery, Amsterdam University Medical Center, Amsterdam, Netherlands; Treatment and Quality of Life and Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands., Aufenacker TJ; Department of Surgery, Rijnstate Hospital, Arnhem, Netherlands., Beets GL; Department of Surgery, Netherlands Cancer Institute, Amsterdam, Netherlands; GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, Netherlands., Bosker RJI; Department of Surgery, Deventer Hospital, Deventer, Netherlands., Buffart TE; Treatment and Quality of Life and Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands; Department of Medical Oncology, Amsterdam University Medical Center, Amsterdam, Netherlands., Burger JW; GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, Netherlands; Department of Surgery, Catharina Hospital, Eindhoven, Netherlands., Dekker E; Treatment and Quality of Life and Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands; Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, Netherlands., Denost Q; Department of Colorectal Surgery, Bordeaux Colorectal Institute, Clinique Tivoli-Ducos, Bordeaux, France., Doornebosch PG; Department of Surgery, IJsselland Hospital, Capelle aan den IJssel, Netherlands., Duijvendijk PV; Department of Surgery, Gelre Hospital, Apeldoorn, Netherlands., Fabry HFJ; Department of Surgery, Bravis Hospital, Roosendaal, Netherlands., Geijsen ED; Department of Radiation Oncology, Amsterdam University Medical Center, Amsterdam, Netherlands., Gerhards MF; Department of Surgery, Onze Lieve Vrouwe Gasthuis, Amsterdam, Netherlands., van Grevenstein WMU; Department of Surgery, University Medical Center Utrecht, Utrecht, Netherlands., Grotenhuis BA; Department of Surgery, Netherlands Cancer Institute, Amsterdam, Netherlands., Hoff C; Department of Surgery, Medisch Centrum Leeuwarden, Leeuwarden, Netherlands., Leijtens JWA; Department of Surgery, Laurentius Hospital, Roermond, Netherlands., Peeters KCMJ; Department of Surgery, Leiden University Medical Center, Leiden, Netherlands., Pronk A; Department of Surgery, Diakonessenhuis, Utrecht, Netherlands., van der Schelling GP; Department of Surgery, Amphia, Breda, Netherlands., Sietses C; Department of Surgery, Gelderse Vallei Hospital, Ede, Netherlands., Smits AB; Department of Surgery, St Antonius Hospital, Nieuwegein, Netherlands., Toorenvliet BR; Department of Surgery, Ikazia Hospital, Rotterdam, Netherlands., van de Ven AWH; Department of Surgery, Flevo Hospital, Almere, Netherlands., Verdaasdonk EGG; Department of Surgery, Jeroen Bosch Hospital, Den Bosch, Netherlands., Vuylsteke RJCLM; Department of Surgery, Spaarne Gasthuis, Haarlem, Netherlands., van Westreenen HL; Department of Surgery, Isala Hospital, Zwolle, Netherlands., de Wilt JHW; Department of Surgery, Radboud University Medical Center, Nijmegen, Netherlands., Zimmerman DDE; Department of Surgery, Elisabeth-TweeSteden Hospital, Tilburg, Netherlands., Lange MM; Department of Pathology, Amsterdam University Medical Center, Amsterdam, Netherlands., van Grieken NCT; Department of Pathology, Amsterdam University Medical Center, Amsterdam, Netherlands., Bastiaansen BAJ; Treatment and Quality of Life and Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands; Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, Netherlands., Hompes R; Department of Surgery, Amsterdam University Medical Center, Amsterdam, Netherlands; Treatment and Quality of Life and Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands., Marijnen CA; Department of Radiation Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands; Department of Radiation Oncology, Leiden University Medical Center, Leiden, Netherlands., Dijkgraaf MGW; Department of Epidemiology and Data Science, Amsterdam University Medical Center, Amsterdam, Netherlands., Moons LMG; Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, Netherlands., Tanis PJ; Department of Surgery, Erasmus Medical Center, Rotterdam, Netherlands., Cunningham C; Department of Colorectal Surgery, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Tuynman JB; Treatment and Quality of Life and Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands. Electronic address: j.tuynman@amsterdamumc.nl. |
| Corporate Authors: | TESAR Study Group |
| Source: | The lancet. Gastroenterology & hepatology [Lancet Gastroenterol Hepatol] 2026 Jul; Vol. 11 (7), pp. 557-569. Date of Electronic Publication: 2026 May 27. |
| Publication Type: | Journal Article; Multicenter Study; Clinical Trial, Phase III; Equivalence Trial; Randomized Controlled Trial; Comparative Study |
| Journal Info: | Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101690683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2468-1253 (Electronic) NLM ISO Abbreviation: Lancet Gastroenterol Hepatol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42202843 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Adjuvant chemoradiotherapy versus completion total mesorectal excision after local excision for early rectal cancer (TESAR): a multicentre, randomised, controlled, phase 3, non-inferiority trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Moolenaar+LR%22">Moolenaar LR</searchLink>; Department of Surgery, Amsterdam University Medical Center, Amsterdam, Netherlands; Treatment and Quality of Life and Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Ali+M%22">Ali M</searchLink>; Department of Surgery, Amsterdam University Medical Center, Amsterdam, Netherlands; Treatment and Quality of Life and Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Aufenacker+TJ%22">Aufenacker TJ</searchLink>; Department of Surgery, Rijnstate Hospital, Arnhem, Netherlands.<br /><searchLink fieldCode="AU" term="%22Beets+GL%22">Beets GL</searchLink>; Department of Surgery, Netherlands Cancer Institute, Amsterdam, Netherlands; GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Bosker+RJI%22">Bosker RJI</searchLink>; Department of Surgery, Deventer Hospital, Deventer, Netherlands.<br /><searchLink fieldCode="AU" term="%22Buffart+TE%22">Buffart TE</searchLink>; Treatment and Quality of Life and Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands; Department of Medical Oncology, Amsterdam University Medical Center, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Burger+JW%22">Burger JW</searchLink>; GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, Netherlands; Department of Surgery, Catharina Hospital, Eindhoven, Netherlands.<br /><searchLink fieldCode="AU" term="%22Dekker+E%22">Dekker E</searchLink>; Treatment and Quality of Life and Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands; Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Denost+Q%22">Denost Q</searchLink>; Department of Colorectal Surgery, Bordeaux Colorectal Institute, Clinique Tivoli-Ducos, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Doornebosch+PG%22">Doornebosch PG</searchLink>; Department of Surgery, IJsselland Hospital, Capelle aan den IJssel, Netherlands.<br /><searchLink fieldCode="AU" term="%22Duijvendijk+PV%22">Duijvendijk PV</searchLink>; Department of Surgery, Gelre Hospital, Apeldoorn, Netherlands.<br /><searchLink fieldCode="AU" term="%22Fabry+HFJ%22">Fabry HFJ</searchLink>; Department of Surgery, Bravis Hospital, Roosendaal, Netherlands.<br /><searchLink fieldCode="AU" term="%22Geijsen+ED%22">Geijsen ED</searchLink>; Department of Radiation Oncology, Amsterdam University Medical Center, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Gerhards+MF%22">Gerhards MF</searchLink>; Department of Surgery, Onze Lieve Vrouwe Gasthuis, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Grevenstein+WMU%22">van Grevenstein WMU</searchLink>; Department of Surgery, University Medical Center Utrecht, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Grotenhuis+BA%22">Grotenhuis BA</searchLink>; Department of Surgery, Netherlands Cancer Institute, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Hoff+C%22">Hoff C</searchLink>; Department of Surgery, Medisch Centrum Leeuwarden, Leeuwarden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Leijtens+JWA%22">Leijtens JWA</searchLink>; Department of Surgery, Laurentius Hospital, Roermond, Netherlands.<br /><searchLink fieldCode="AU" term="%22Peeters+KCMJ%22">Peeters KCMJ</searchLink>; Department of Surgery, Leiden University Medical Center, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Pronk+A%22">Pronk A</searchLink>; Department of Surgery, Diakonessenhuis, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Schelling+GP%22">van der Schelling GP</searchLink>; Department of Surgery, Amphia, Breda, Netherlands.<br /><searchLink fieldCode="AU" term="%22Sietses+C%22">Sietses C</searchLink>; Department of Surgery, Gelderse Vallei Hospital, Ede, Netherlands.<br /><searchLink fieldCode="AU" term="%22Smits+AB%22">Smits AB</searchLink>; Department of Surgery, St Antonius Hospital, Nieuwegein, Netherlands.<br /><searchLink fieldCode="AU" term="%22Toorenvliet+BR%22">Toorenvliet BR</searchLink>; Department of Surgery, Ikazia Hospital, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+de+Ven+AWH%22">van de Ven AWH</searchLink>; Department of Surgery, Flevo Hospital, Almere, Netherlands.<br /><searchLink fieldCode="AU" term="%22Verdaasdonk+EGG%22">Verdaasdonk EGG</searchLink>; Department of Surgery, Jeroen Bosch Hospital, Den Bosch, Netherlands.<br /><searchLink fieldCode="AU" term="%22Vuylsteke+RJCLM%22">Vuylsteke RJCLM</searchLink>; Department of Surgery, Spaarne Gasthuis, Haarlem, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Westreenen+HL%22">van Westreenen HL</searchLink>; Department of Surgery, Isala Hospital, Zwolle, Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Wilt+JHW%22">de Wilt JHW</searchLink>; Department of Surgery, Radboud University Medical Center, Nijmegen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Zimmerman+DDE%22">Zimmerman DDE</searchLink>; Department of Surgery, Elisabeth-TweeSteden Hospital, Tilburg, Netherlands.<br /><searchLink fieldCode="AU" term="%22Lange+MM%22">Lange MM</searchLink>; Department of Pathology, Amsterdam University Medical Center, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Grieken+NCT%22">van Grieken NCT</searchLink>; Department of Pathology, Amsterdam University Medical Center, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Bastiaansen+BAJ%22">Bastiaansen BAJ</searchLink>; Treatment and Quality of Life and Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands; Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Hompes+R%22">Hompes R</searchLink>; Department of Surgery, Amsterdam University Medical Center, Amsterdam, Netherlands; Treatment and Quality of Life and Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Marijnen+CA%22">Marijnen CA</searchLink>; Department of Radiation Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands; Department of Radiation Oncology, Leiden University Medical Center, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Dijkgraaf+MGW%22">Dijkgraaf MGW</searchLink>; Department of Epidemiology and Data Science, Amsterdam University Medical Center, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Moons+LMG%22">Moons LMG</searchLink>; Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Tanis+PJ%22">Tanis PJ</searchLink>; Department of Surgery, Erasmus Medical Center, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Cunningham+C%22">Cunningham C</searchLink>; Department of Colorectal Surgery, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Tuynman+JB%22">Tuynman JB</searchLink>; Treatment and Quality of Life and Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands. Electronic address: j.tuynman@amsterdamumc.nl. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22TESAR+Study+Group%22">TESAR Study Group</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101690683%22">The lancet. Gastroenterology & hepatology</searchLink> [Lancet Gastroenterol Hepatol] 2026 Jul; Vol. 11 (7), pp. 557-569. <i>Date of Electronic Publication: </i>2026 May 27. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Multicenter Study; Clinical Trial, Phase III; Equivalence Trial; Randomized Controlled Trial; Comparative Study – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+B%2EV%22">Elsevier B.V </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101690683 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2468-1253 (Electronic) <i>NLM ISO Abbreviation: </i>Lancet Gastroenterol Hepatol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42202843 |
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