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Structural and mechanistic insights into the inhibition of Plasmodium falciparum MDR1.

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Title: Structural and mechanistic insights into the inhibition of Plasmodium falciparum MDR1.
Authors: Zhao Z; Genetic Diseases Key Laboratory of Sichuan Province, Department of Medical Genetics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, PR China.; Sichuan-Chongqing Joint Key Laboratory of Pathology and Laboratory Medicine, Jinfeng Laboratory, Chongqing, PR China., Li J; Department of Obstetrics, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu, China., Wang X; Genetic Diseases Key Laboratory of Sichuan Province, Department of Medical Genetics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, PR China.; Sichuan-Chongqing Joint Key Laboratory of Pathology and Laboratory Medicine, Jinfeng Laboratory, Chongqing, PR China., Liu X; Genetic Diseases Key Laboratory of Sichuan Province, Department of Medical Genetics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, PR China.; Sichuan-Chongqing Joint Key Laboratory of Pathology and Laboratory Medicine, Jinfeng Laboratory, Chongqing, PR China., Wang N; State Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China., Xu H; State Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China., Quan C; Genetic Diseases Key Laboratory of Sichuan Province, Department of Medical Genetics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, PR China.; Sichuan-Chongqing Joint Key Laboratory of Pathology and Laboratory Medicine, Jinfeng Laboratory, Chongqing, PR China., Gao Y; Genetic Diseases Key Laboratory of Sichuan Province, Department of Medical Genetics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, PR China.; Sichuan-Chongqing Joint Key Laboratory of Pathology and Laboratory Medicine, Jinfeng Laboratory, Chongqing, PR China., Zhang J; Genetic Diseases Key Laboratory of Sichuan Province, Department of Medical Genetics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, PR China.; Sichuan-Chongqing Joint Key Laboratory of Pathology and Laboratory Medicine, Jinfeng Laboratory, Chongqing, PR China., Wang X; Department of Obstetrics, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu, China., Guo L; Department of Obstetrics, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu, China., Kato N; Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan., Deng D; Department of Obstetrics, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu, China. dengd@scu.edu.cn.; Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, China. dengd@scu.edu.cn., Jiang X; Genetic Diseases Key Laboratory of Sichuan Province, Department of Medical Genetics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, PR China. jiangx08@uestc.edu.cn.; Sichuan-Chongqing Joint Key Laboratory of Pathology and Laboratory Medicine, Jinfeng Laboratory, Chongqing, PR China. jiangx08@uestc.edu.cn.
Source: Nature communications [Nat Commun] 2026 May 27; Vol. 17 (1). Date of Electronic Publication: 2026 May 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Structural and mechanistic insights into the inhibition of Plasmodium falciparum MDR1.
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  Data: <searchLink fieldCode="AU" term="%22Zhao+Z%22">Zhao Z</searchLink>; Genetic Diseases Key Laboratory of Sichuan Province, Department of Medical Genetics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, PR China.; Sichuan-Chongqing Joint Key Laboratory of Pathology and Laboratory Medicine, Jinfeng Laboratory, Chongqing, PR China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Obstetrics, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Genetic Diseases Key Laboratory of Sichuan Province, Department of Medical Genetics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, PR China.; Sichuan-Chongqing Joint Key Laboratory of Pathology and Laboratory Medicine, Jinfeng Laboratory, Chongqing, PR China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Genetic Diseases Key Laboratory of Sichuan Province, Department of Medical Genetics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, PR China.; Sichuan-Chongqing Joint Key Laboratory of Pathology and Laboratory Medicine, Jinfeng Laboratory, Chongqing, PR China.<br /><searchLink fieldCode="AU" term="%22Wang+N%22">Wang N</searchLink>; State Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Xu+H%22">Xu H</searchLink>; State Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Quan+C%22">Quan C</searchLink>; Genetic Diseases Key Laboratory of Sichuan Province, Department of Medical Genetics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, PR China.; Sichuan-Chongqing Joint Key Laboratory of Pathology and Laboratory Medicine, Jinfeng Laboratory, Chongqing, PR China.<br /><searchLink fieldCode="AU" term="%22Gao+Y%22">Gao Y</searchLink>; Genetic Diseases Key Laboratory of Sichuan Province, Department of Medical Genetics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, PR China.; Sichuan-Chongqing Joint Key Laboratory of Pathology and Laboratory Medicine, Jinfeng Laboratory, Chongqing, PR China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Genetic Diseases Key Laboratory of Sichuan Province, Department of Medical Genetics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, PR China.; Sichuan-Chongqing Joint Key Laboratory of Pathology and Laboratory Medicine, Jinfeng Laboratory, Chongqing, PR China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Obstetrics, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Guo+L%22">Guo L</searchLink>; Department of Obstetrics, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Kato+N%22">Kato N</searchLink>; Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Deng+D%22">Deng D</searchLink>; Department of Obstetrics, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu, China. dengd@scu.edu.cn.; Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, China. dengd@scu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Jiang+X%22">Jiang X</searchLink>; Genetic Diseases Key Laboratory of Sichuan Province, Department of Medical Genetics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, PR China. jiangx08@uestc.edu.cn.; Sichuan-Chongqing Joint Key Laboratory of Pathology and Laboratory Medicine, Jinfeng Laboratory, Chongqing, PR China. jiangx08@uestc.edu.cn.
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