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Excitatory paraventricular thalamus-posterior insular cortex circuit mediates pain-anxiety comorbidity in diabetic neuropathy.

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Title: Excitatory paraventricular thalamus-posterior insular cortex circuit mediates pain-anxiety comorbidity in diabetic neuropathy.
Authors: Wei M; Department of Anesthesiology, Peking University Third Hospital, Beijing, China., Shou J; Department of Anesthesiology, Peking University Third Hospital, Beijing, China., Yang J; Department of Anesthesiology, Peking University Third Hospital, Beijing, China., Cai S; Neuroscience Research Institute, Peking University, Beijing, China.; Department of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.; Key Laboratory for Neuroscience, Ministry of Education of China and National Health Commission of China, Beijing, China., Bai Q; Neuroscience Research Institute, Peking University, Beijing, China.; Department of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.; Key Laboratory for Neuroscience, Ministry of Education of China and National Health Commission of China, Beijing, China., Hou J; Neuroscience Research Institute, Peking University, Beijing, China.; Department of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.; Key Laboratory for Neuroscience, Ministry of Education of China and National Health Commission of China, Beijing, China., Jiang Y; Department of Anesthesiology, Peking University Third Hospital, Beijing, China., Shen S; Department of Anesthesiology, Peking University Third Hospital, Beijing, China., Yu Z; Department of Anesthesiology, Peking University Third Hospital, Beijing, China., Zhao X; Department of Anesthesiology, Peking University Third Hospital, Beijing, China., Han Y; Department of Anesthesiology, Peking University Third Hospital, Beijing, China., Cai J; Neuroscience Research Institute, Peking University, Beijing, China.; Department of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.; Key Laboratory for Neuroscience, Ministry of Education of China and National Health Commission of China, Beijing, China., Yang XW; Department of Endocrinology, Peking University First Hospital, Beijing, China., Li Z; Department of Anesthesiology, Peking University Third Hospital, Beijing, China., Ma D; Department of Anesthesiology, The First Affiliated Hospital, Ningbo University, Ningbo, China. d.ma@imperial.ac.uk.; Perioperative and Systems Medicine Laboratory, Department of Anesthesiology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescent's Health and Diseases, Hangzhou, China. d.ma@imperial.ac.uk.; Division of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, London, UK. d.ma@imperial.ac.uk., Xing GG; Neuroscience Research Institute, Peking University, Beijing, China. ggxing@bjmu.edu.cn.; Department of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China. ggxing@bjmu.edu.cn.; Key Laboratory for Neuroscience, Ministry of Education of China and National Health Commission of China, Beijing, China. ggxing@bjmu.edu.cn., Li M; Department of Anesthesiology, Peking University Third Hospital, Beijing, China. liminanesth@bjmu.edu.cn.
Source: Translational psychiatry [Transl Psychiatry] 2026 May 27; Vol. 16 (1). Date of Electronic Publication: 2026 May 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Excitatory paraventricular thalamus-posterior insular cortex circuit mediates pain-anxiety comorbidity in diabetic neuropathy.
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  Data: <searchLink fieldCode="AU" term="%22Wei+M%22">Wei M</searchLink>; Department of Anesthesiology, Peking University Third Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Shou+J%22">Shou J</searchLink>; Department of Anesthesiology, Peking University Third Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; Department of Anesthesiology, Peking University Third Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Cai+S%22">Cai S</searchLink>; Neuroscience Research Institute, Peking University, Beijing, China.; Department of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.; Key Laboratory for Neuroscience, Ministry of Education of China and National Health Commission of China, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Bai+Q%22">Bai Q</searchLink>; Neuroscience Research Institute, Peking University, Beijing, China.; Department of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.; Key Laboratory for Neuroscience, Ministry of Education of China and National Health Commission of China, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Hou+J%22">Hou J</searchLink>; Neuroscience Research Institute, Peking University, Beijing, China.; Department of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.; Key Laboratory for Neuroscience, Ministry of Education of China and National Health Commission of China, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Jiang+Y%22">Jiang Y</searchLink>; Department of Anesthesiology, Peking University Third Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Shen+S%22">Shen S</searchLink>; Department of Anesthesiology, Peking University Third Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Yu+Z%22">Yu Z</searchLink>; Department of Anesthesiology, Peking University Third Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhao+X%22">Zhao X</searchLink>; Department of Anesthesiology, Peking University Third Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Han+Y%22">Han Y</searchLink>; Department of Anesthesiology, Peking University Third Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Cai+J%22">Cai J</searchLink>; Neuroscience Research Institute, Peking University, Beijing, China.; Department of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.; Key Laboratory for Neuroscience, Ministry of Education of China and National Health Commission of China, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Yang+XW%22">Yang XW</searchLink>; Department of Endocrinology, Peking University First Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Department of Anesthesiology, Peking University Third Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Ma+D%22">Ma D</searchLink>; Department of Anesthesiology, The First Affiliated Hospital, Ningbo University, Ningbo, China. d.ma@imperial.ac.uk.; Perioperative and Systems Medicine Laboratory, Department of Anesthesiology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescent's Health and Diseases, Hangzhou, China. d.ma@imperial.ac.uk.; Division of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, London, UK. d.ma@imperial.ac.uk.<br /><searchLink fieldCode="AU" term="%22Xing+GG%22">Xing GG</searchLink>; Neuroscience Research Institute, Peking University, Beijing, China. ggxing@bjmu.edu.cn.; Department of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China. ggxing@bjmu.edu.cn.; Key Laboratory for Neuroscience, Ministry of Education of China and National Health Commission of China, Beijing, China. ggxing@bjmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; Department of Anesthesiology, Peking University Third Hospital, Beijing, China. liminanesth@bjmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101562664%22">Translational psychiatry</searchLink> [Transl Psychiatry] 2026 May 27; Vol. 16 (1). <i>Date of Electronic Publication: </i>2026 May 27.
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        Value: 10.1038/s41398-026-04110-6
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        Text: English
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