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Universal transcriptomic hallmarks of mammalian ageing and mortality.

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Title: Universal transcriptomic hallmarks of mammalian ageing and mortality.
Authors: Tyshkovskiy A; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. atyshkovskii@bwh.harvard.edu., Kholdina D; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia.; Faculty of Bioengineering and Bioinformatics, Moscow State University, Moscow, Russia., Davitadze M; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia.; Faculty of Bioengineering and Bioinformatics, Moscow State University, Moscow, Russia., Molière A; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Institute of Molecular Health Sciences, Department of Biology, ETH Zürich, Zurich, Switzerland., Moldakozhayev A; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.; Metabolic Disorders and Complications Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.; Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada., Tongu Y; Tohoku University School of Medicine, Sendai, Japan.; Department of Clinical Biology and Hormonal Regulation, Tohoku University Graduate School of Medicine, Sendai, Japan., Kasahara T; Department of Clinical Biology and Hormonal Regulation, Tohoku University Graduate School of Medicine, Sendai, Japan.; Department of Nephrology, Tohoku University Graduate School of Medicine, Sendai, Japan., Glubokov D; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Eames A; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Kats LM; Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia., Vladimirova A; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Faculty of Engineering Sciences, Heidelberg University, Heidelberg, Germany., Ying K; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; T. H. Chan School of Public Health, Harvard University, Boston, MA, USA., Liu H; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Massachusetts College of Pharmacy and Health Sciences, Boston, MA, USA., Zhang B; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Khasanova U; Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia.; Faculty of Bioengineering and Bioinformatics, Moscow State University, Moscow, Russia., Moqri M; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Genetics, School of Medicine, Stanford University, Stanford, CA, USA., Van Raamsdonk JM; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.; Metabolic Disorders and Complications Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.; Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.; Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, Quebec, Canada., Harrison DE; The Jackson Laboratory, Bar Harbor, ME, USA., Strong R; Geriatric Research, Education and Clinical Center and Research Service, South Texas Veterans Health Care System, Department of Pharmacology, Barshop Institute for Longevity and Aging Studies at The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Abe T; Department of Clinical Biology and Hormonal Regulation, Tohoku University Graduate School of Medicine, Sendai, Japan.; Department of Nephrology, Tohoku University Graduate School of Medicine, Sendai, Japan.; Division of Medical Science, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan., Dmitriev SE; Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia.; Faculty of Bioengineering and Bioinformatics, Moscow State University, Moscow, Russia., Gladyshev VN; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. vgladyshev@bwh.harvard.edu.; Broad Institute of Harvard and MIT, Cambridge, MA, USA. vgladyshev@bwh.harvard.edu.
Source: Nature [Nature] 2026 Jun; Vol. 654 (8117), pp. 173-188. Date of Electronic Publication: 2026 May 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: Universal transcriptomic hallmarks of mammalian ageing and mortality.
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Chan School of Public Health, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Massachusetts College of Pharmacy and Health Sciences, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+B%22">Zhang B</searchLink>; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Khasanova+U%22">Khasanova U</searchLink>; Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia.; Faculty of Bioengineering and Bioinformatics, Moscow State University, Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Moqri+M%22">Moqri M</searchLink>; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Genetics, School of Medicine, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Van+Raamsdonk+JM%22">Van Raamsdonk JM</searchLink>; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.; Metabolic Disorders and Complications Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.; Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.; Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Harrison+DE%22">Harrison DE</searchLink>; The Jackson Laboratory, Bar Harbor, ME, USA.<br /><searchLink fieldCode="AU" term="%22Strong+R%22">Strong R</searchLink>; Geriatric Research, Education and Clinical Center and Research Service, South Texas Veterans Health Care System, Department of Pharmacology, Barshop Institute for Longevity and Aging Studies at The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Abe+T%22">Abe T</searchLink>; Department of Clinical Biology and Hormonal Regulation, Tohoku University Graduate School of Medicine, Sendai, Japan.; Department of Nephrology, Tohoku University Graduate School of Medicine, Sendai, Japan.; Division of Medical Science, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Dmitriev+SE%22">Dmitriev SE</searchLink>; Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia.; Faculty of Bioengineering and Bioinformatics, Moscow State University, Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Gladyshev+VN%22">Gladyshev VN</searchLink>; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. vgladyshev@bwh.harvard.edu.; Broad Institute of Harvard and MIT, Cambridge, MA, USA. vgladyshev@bwh.harvard.edu.
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