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αKG-mediated carnitine synthesis drives DNA repair via histone acetylation.

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Title: αKG-mediated carnitine synthesis drives DNA repair via histone acetylation.
Authors: Uboveja A; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.; Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Yang B; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.; Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Tsinghua University, Beijing, China., Buj R; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.; Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Amalric A; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.; Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Aging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA., Wang H; Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Tangudu NK; Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Cole AR; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.; Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Disharoon JA; Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA., Fang RS; Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Levasseur E; Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Naruse M; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.; Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Huang Z; Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Megill E; Aging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA., Kantner DS; Aging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA., Chatoff A; Aging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA., Ahmad H; Aging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA., Marcinkiewicz MM; Aging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA., Graff S; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA., De Pieri E; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA., Huacachino AA; Aging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA., Vendetti FP; Department of Radiation Oncology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Danielson J; Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Dahl ES; Department of Cellular & Molecular Physiology, Penn State College of Medicine, Hershey, PA, USA., Pennise JL; Aging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA., Elishaev E; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Jaccard A; Aging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA, USA., Borho L; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine and Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA., Post MD; Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Cooper K; Biostatistics Facility, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA., Modugno F; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine and Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA., Hempel N; Department of Medicine, Division of Hematology/Oncology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Stallaert W; Department of Computational & Systems Biology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Bakkenist CJ; Department of Radiation Oncology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Sidoli S; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA., Wellen KE; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA, USA., Bitler BG; Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Long DT; Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA., Snyder NW; Aging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA. NateWSnyder@temple.edu., Aird KM; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA. kaird@wistar.org.; Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. kaird@wistar.org.
Source: Nature [Nature] 2026 Jul; Vol. 655 (8123), pp. 790-800. Date of Electronic Publication: 2026 May 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: αKG-mediated carnitine synthesis drives DNA repair via histone acetylation.
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