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Human haematopoietic stem cells remember inflammatory stress.

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Title: Human haematopoietic stem cells remember inflammatory stress.
Authors: Zeng AGX; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Nagree MS; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Jakobsen NA; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford, UK., Shah S; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Varesi A; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Kang JRW; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.; Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Murison A; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Cheong JG; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School, NewYork, NY, USA., Turkalj S; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford, UK.; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA, USA., Zhang X; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Radtke FA; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford, UK., Abera TA; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Lim INX; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Jin L; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Araújo J; Department of Hematology, Centro Hospitalar Universitário de São João, Porto, Portugal.; Faculty of Medicine, University of Porto, Porto, Portugal.; Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal.; Instituto Nacional de Investigação Biomédica, University of Porto, Porto, Portugal., Aguilar-Navarro AG; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Parris D; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., McLeod J; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Kim H; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Lee HS; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Zhang L; Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada.; Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, British Columbia, Canada., Boulanger M; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Bader E; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.; Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Gbeha E; Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Parkhurst CN; Division of Pulmonary and Critical Care Medicine, Weill Cornell Graduate School, NewYork, NY, USA., Wagenblast E; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Flores-Figueroa E; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Wang B; Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada.; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.; Vector Institute, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Schwartz GW; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Shultz LD; The Jackson Laboratory, Bar Harbor, ME, USA., Nam AS; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Grimes HL; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA., Josefowicz SZ; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School, NewYork, NY, USA., Awadalla P; Nuffield Department of Population Health, Big Data Institute, University of Oxford, Oxford, UK., Vyas P; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford, UK.; Department of Clinical Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Dick JE; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Xie SZ; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. stephanie.xie@uhn.ca.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. stephanie.xie@uhn.ca.
Source: Nature [Nature] 2026 Jul; Vol. 655 (8122), pp. 458-467. Date of Electronic Publication: 2026 May 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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