Polygenic risk score with KLK3 SNP-SNP interaction pairs for predicting prostate cancer aggressiveness.
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| Title: | Polygenic risk score with KLK3 SNP-SNP interaction pairs for predicting prostate cancer aggressiveness. |
|---|---|
| Authors: | Lin HY; Biostatistics and Data Science Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, USA. hlin1@lsuhsc.edu., Sarkar I; Biostatistics and Data Science Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Mazumder H; Biostatistics and Data Science Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Huang PY; Information and Communications Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan., Muir KR; Division of Population Health, Health Services Research and Primary Care, University of Manchester, Oxford Road, Manchester, UK., Schleutker J; Institute of Biomedicine, University of Turku, Turku, Finland.; Genomics, Laboratory Division, Turku University Hospital, Turku, Finland., Pashayan N; Department of Public Health & Primary Care, Strangeways Research Laboratory, Worts Causeway, Cambridge, UK.; Department of Applied Health Research, University College London, London, UK., Batra J; School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia.; Centre for Genomics and Personalised Health, Queensland University of Technology, Brisbane, QLD, Australia.; Translational Research Institute, QUT, Woolloongabba, Brisbane, QLD, Australia., Neal DE; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.; Department of Oncology, University of Cambridge, Cambridge, UK.; Cancer Research UK, Li Ka Shing Centre, Cambridge Research Institute, Cambridge, UK., Grönberg H; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Nielsen SF; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Nordestgaard BG; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Tangen CM; SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., MacInnis RJ; Cancer Epidemiology Division, Cancer Council Victoria, East Melbourne, VIC, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia., Wolk A; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Albanes D; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA., Travis RC; Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Stanford JL; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA., Mucci LA; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Kibel AS; Division of Urologic Surgery, Brigham and Women's Hospital, Boston, MA, USA., Cussenot O; Sorbonne Universite, Tenon Hospital, Paris, France.; CeRePP, Tenon Hospital, Paris, France., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA., Koutros S; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA., Sørensen KD; Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus N, Denmark., Cybulski C; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Grindedal EM; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway., Hoegel J; Institute for Human Genetics, University Hospital Ulm, Ulm, Germany., Maier C; Humangenetik Tuebingen, Tuebingen, Germany., Hamilton RJ; Dept. of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, ON, Canada.; Dept. of Surgery (Urology), University of Toronto, Toronto, ON, Canada., Rosenstein BS; Department of Radiation Oncology and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Vega A; Fundación Pública Galega Medicina Xenómica, Santiago de Compostela, Spain.; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain.; Centro de Investigación en Red de Enfermedades Raras (CIBERER), Madrid, Spain., Kogevinas M; ISGlobal, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología Salud Pública (CIBERESP), Madrid, Spain., Wiklund F; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Penney KL; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA., Teixeira MR; Department of Laboratory Genetics, Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center, Porto, Portugal.; Cancer Genetics Group, IPO Porto Research Center (CI-IPOP)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal.; School of Medicine and Biomedical Sciences (ICBAS), University of Porto, Porto, Portugal., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., John EM; Departments of Epidemiology & Population Health and of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA., Kaneva R; Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University of Sofia, Sofia, Bulgaria., Logothetis CJ; The University of Texas M. D. Anderson Cancer Center, Department of Genitourinary Medical Oncology, Houston, TX, USA., Neuhausen SL; Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA., De Ruyck K; Ghent University, Faculty of Medicine and Health Sciences, Basic Medical Sciences, Gent, Belgium., Ost P; Department of Radiotherapy, Ghent University Hospital, Gent, Belgium., Gamulin M; Department of Oncology, University Hospital Centre Zagreb, University of Zagreb, School of Medicine, Zagreb, Croatia., Usmani N; Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada.; Division of Radiation Oncology, Cross Cancer Institute, Edmonton, AB, Canada., Claessens F; Department of Cellular and Molecular Medicine, Molecular Endocrinology Laboratory, KU Leuven, Belgium., Castelao JE; Genetic Oncology Unit, CHUVI Hospital, Complexo Hospitalario Universitario de Vigo, Instituto de Investigación Biomédica Galicia Sur (IISGS), Vigo (Pontevedra), Spain., Townsend PA; Division of Cancer Sciences, Manchester Cancer Research Centre, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, Health Innovation Manchester, University of Manchester, Manchester, UK.; The University of Surrey, Guildford, Surrey, UK., Kote-Jarai Z; The Institute of Cancer Research, London, UK., Haiman CA; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA., Eeles RA; The Institute of Cancer Research, London, UK.; Royal Marsden NHS Foundation Trust, London, UK., Park JY; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA. |
| Corporate Authors: | UKGPCS collaborators, APCB BioResource (Australian Prostate Cancer BioResource), PRACTICAL consortium |
| Source: | Communications medicine [Commun Med (Lond)] 2026 May 28. Date of Electronic Publication: 2026 May 28. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Portfolio Country of Publication: England NLM ID: 9918250414506676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2730-664X (Electronic) Linking ISSN: 2730664X NLM ISO Abbreviation: Commun Med (Lond) |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42204244 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Polygenic risk score with KLK3 SNP-SNP interaction pairs for predicting prostate cancer aggressiveness. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Lin+HY%22">Lin HY</searchLink>; Biostatistics and Data Science Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, USA. hlin1@lsuhsc.edu.<br /><searchLink fieldCode="AU" term="%22Sarkar+I%22">Sarkar I</searchLink>; Biostatistics and Data Science Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, USA.<br /><searchLink fieldCode="AU" term="%22Mazumder+H%22">Mazumder H</searchLink>; Biostatistics and Data Science Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, USA.<br /><searchLink fieldCode="AU" term="%22Huang+PY%22">Huang PY</searchLink>; Information and Communications Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Muir+KR%22">Muir KR</searchLink>; Division of Population Health, Health Services Research and Primary Care, University of Manchester, Oxford Road, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Schleutker+J%22">Schleutker J</searchLink>; Institute of Biomedicine, University of Turku, Turku, Finland.; Genomics, Laboratory Division, Turku University Hospital, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Pashayan+N%22">Pashayan N</searchLink>; Department of Public Health & Primary Care, Strangeways Research Laboratory, Worts Causeway, Cambridge, UK.; Department of Applied Health Research, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Batra+J%22">Batra J</searchLink>; School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia.; Centre for Genomics and Personalised Health, Queensland University of Technology, Brisbane, QLD, Australia.; Translational Research Institute, QUT, Woolloongabba, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Neal+DE%22">Neal DE</searchLink>; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.; Department of Oncology, University of Cambridge, Cambridge, UK.; Cancer Research UK, Li Ka Shing Centre, Cambridge Research Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Grönberg+H%22">Grönberg H</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Nielsen+SF%22">Nielsen SF</searchLink>; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Nordestgaard+BG%22">Nordestgaard BG</searchLink>; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Tangen+CM%22">Tangen CM</searchLink>; SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22MacInnis+RJ%22">MacInnis RJ</searchLink>; Cancer Epidemiology Division, Cancer Council Victoria, East Melbourne, VIC, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Wolk+A%22">Wolk A</searchLink>; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Albanes+D%22">Albanes D</searchLink>; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Travis+RC%22">Travis RC</searchLink>; Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Stanford+JL%22">Stanford JL</searchLink>; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Mucci+LA%22">Mucci LA</searchLink>; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kibel+AS%22">Kibel AS</searchLink>; Division of Urologic Surgery, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cussenot+O%22">Cussenot O</searchLink>; Sorbonne Universite, Tenon Hospital, Paris, France.; CeRePP, Tenon Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Berndt+SI%22">Berndt SI</searchLink>; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Koutros+S%22">Koutros S</searchLink>; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Sørensen+KD%22">Sørensen KD</searchLink>; Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus N, Denmark.<br /><searchLink fieldCode="AU" term="%22Cybulski+C%22">Cybulski C</searchLink>; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.<br /><searchLink fieldCode="AU" term="%22Grindedal+EM%22">Grindedal EM</searchLink>; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Hoegel+J%22">Hoegel J</searchLink>; Institute for Human Genetics, University Hospital Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Maier+C%22">Maier C</searchLink>; Humangenetik Tuebingen, Tuebingen, Germany.<br /><searchLink fieldCode="AU" term="%22Hamilton+RJ%22">Hamilton RJ</searchLink>; Dept. of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, ON, Canada.; Dept. of Surgery (Urology), University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Rosenstein+BS%22">Rosenstein BS</searchLink>; Department of Radiation Oncology and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Vega+A%22">Vega A</searchLink>; Fundación Pública Galega Medicina Xenómica, Santiago de Compostela, Spain.; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain.; Centro de Investigación en Red de Enfermedades Raras (CIBERER), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Kogevinas+M%22">Kogevinas M</searchLink>; ISGlobal, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología Salud Pública (CIBERESP), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Wiklund+F%22">Wiklund F</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Penney+KL%22">Penney KL</searchLink>; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Teixeira+MR%22">Teixeira MR</searchLink>; Department of Laboratory Genetics, Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center, Porto, Portugal.; Cancer Genetics Group, IPO Porto Research Center (CI-IPOP)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal.; School of Medicine and Biomedical Sciences (ICBAS), University of Porto, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Brenner+H%22">Brenner H</searchLink>; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22John+EM%22">John EM</searchLink>; Departments of Epidemiology & Population Health and of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kaneva+R%22">Kaneva R</searchLink>; Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University of Sofia, Sofia, Bulgaria.<br /><searchLink fieldCode="AU" term="%22Logothetis+CJ%22">Logothetis CJ</searchLink>; The University of Texas M. D. Anderson Cancer Center, Department of Genitourinary Medical Oncology, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Neuhausen+SL%22">Neuhausen SL</searchLink>; Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22De+Ruyck+K%22">De Ruyck K</searchLink>; Ghent University, Faculty of Medicine and Health Sciences, Basic Medical Sciences, Gent, Belgium.<br /><searchLink fieldCode="AU" term="%22Ost+P%22">Ost P</searchLink>; Department of Radiotherapy, Ghent University Hospital, Gent, Belgium.<br /><searchLink fieldCode="AU" term="%22Gamulin+M%22">Gamulin M</searchLink>; Department of Oncology, University Hospital Centre Zagreb, University of Zagreb, School of Medicine, Zagreb, Croatia.<br /><searchLink fieldCode="AU" term="%22Usmani+N%22">Usmani N</searchLink>; Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada.; Division of Radiation Oncology, Cross Cancer Institute, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Claessens+F%22">Claessens F</searchLink>; Department of Cellular and Molecular Medicine, Molecular Endocrinology Laboratory, KU Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Castelao+JE%22">Castelao JE</searchLink>; Genetic Oncology Unit, CHUVI Hospital, Complexo Hospitalario Universitario de Vigo, Instituto de Investigación Biomédica Galicia Sur (IISGS), Vigo (Pontevedra), Spain.<br /><searchLink fieldCode="AU" term="%22Townsend+PA%22">Townsend PA</searchLink>; Division of Cancer Sciences, Manchester Cancer Research Centre, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, Health Innovation Manchester, University of Manchester, Manchester, UK.; The University of Surrey, Guildford, Surrey, UK.<br /><searchLink fieldCode="AU" term="%22Kote-Jarai+Z%22">Kote-Jarai Z</searchLink>; The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Haiman+CA%22">Haiman CA</searchLink>; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Eeles+RA%22">Eeles RA</searchLink>; The Institute of Cancer Research, London, UK.; Royal Marsden NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Park+JY%22">Park JY</searchLink>; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22UKGPCS+collaborators%22">UKGPCS collaborators</searchLink><br /><searchLink fieldCode="CA" term="%22APCB+BioResource+%28Australian+Prostate+Cancer+BioResource%29%22">APCB BioResource (Australian Prostate Cancer BioResource)</searchLink><br /><searchLink fieldCode="CA" term="%22PRACTICAL+consortium%22">PRACTICAL consortium</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229918250414506676%22">Communications medicine</searchLink> [Commun Med (Lond)] 2026 May 28. <i>Date of Electronic Publication: </i>2026 May 28. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Portfolio%22">Nature Portfolio </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9918250414506676 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2730-664X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222730664X%22">2730664X </searchLink><i>NLM ISO Abbreviation: </i>Commun Med (Lond) |
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