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Ras-MAPK inhibition induces AXIN1 loss in colorectal cancer by mTOR associated suppression of protein synthesis.

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Title: Ras-MAPK inhibition induces AXIN1 loss in colorectal cancer by mTOR associated suppression of protein synthesis.
Authors: Venkatachalam N; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany., Wang L; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany., Muthukumarana N; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.; Division of Biochemistry, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Center for Molecular Biology of Heidelberg University (ZMBH), German Cancer Research Center (DKFZ)-ZMBH Alliance, Heidelberg, Germany., Ihnatko R; Division of Proteomics of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Krijgsveld J; Division of Proteomics of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Skabkina O; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany., Leipertz A; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany., Chen Y; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany., Sui P; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.; Division of Biochemistry, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Center for Molecular Biology of Heidelberg University (ZMBH), German Cancer Research Center (DKFZ)-ZMBH Alliance, Heidelberg, Germany.; Junior Clinical Cooperation Unit Translational Gastrointestinal Oncology and Preclinical Models, German Cancer Research Center (DKFZ), Heidelberg, Germany.; DKFZ Hector Cancer Institute at University Medical Center Mannheim, Mannheim, Germany.; Mannheim Cancer Center, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Zheng Q; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany., Tong P; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.; Division of Biochemistry, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Center for Molecular Biology of Heidelberg University (ZMBH), German Cancer Research Center (DKFZ)-ZMBH Alliance, Heidelberg, Germany., Liu X; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany., Descot A; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany., Schewe M; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany., Diamante G; Cancer Progression and Metastasis Group, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI- STEM gGmbH), Heidelberg, Germany., Jackstadt R; Cancer Progression and Metastasis Group, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI- STEM gGmbH), Heidelberg, Germany., Brochhausen C; DKFZ Hector Cancer Institute at University Medical Center Mannheim, Mannheim, Germany.; Institute of Pathology, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany., Betge J; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.; Junior Clinical Cooperation Unit Translational Gastrointestinal Oncology and Preclinical Models, German Cancer Research Center (DKFZ), Heidelberg, Germany.; DKFZ Hector Cancer Institute at University Medical Center Mannheim, Mannheim, Germany., Boonekamp K; Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Institute of Human Genetics, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany., Boutros M; Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Institute of Human Genetics, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany., Stoecklin G; Division of Biochemistry, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Center for Molecular Biology of Heidelberg University (ZMBH), German Cancer Research Center (DKFZ)-ZMBH Alliance, Heidelberg, Germany.; DKFZ Hector Cancer Institute at University Medical Center Mannheim, Mannheim, Germany.; Mannheim Cancer Center, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Ebert M; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.; DKFZ Hector Cancer Institute at University Medical Center Mannheim, Mannheim, Germany.; Mannheim Cancer Center, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Molecular Medicine Partnership Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Schott J; Division of Biochemistry, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Center for Molecular Biology of Heidelberg University (ZMBH), German Cancer Research Center (DKFZ)-ZMBH Alliance, Heidelberg, Germany.; DKFZ Hector Cancer Institute at University Medical Center Mannheim, Mannheim, Germany.; Mannheim Cancer Center, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Zhan T; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany. tianzuo.zhan@medma.uni-heidelberg.de.; DKFZ Hector Cancer Institute at University Medical Center Mannheim, Mannheim, Germany. tianzuo.zhan@medma.uni-heidelberg.de.; Mannheim Cancer Center, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. tianzuo.zhan@medma.uni-heidelberg.de.; Molecular Medicine Partnership Unit, European Molecular Biology Laboratory, Heidelberg, Germany. tianzuo.zhan@medma.uni-heidelberg.de.
Source: Cell communication and signaling : CCS [Cell Commun Signal] 2026 May 27; Vol. 24 (1). Date of Electronic Publication: 2026 May 27.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101170464 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-811X (Electronic) Linking ISSN: 1478811X NLM ISO Abbreviation: Cell Commun Signal Subsets: MEDLINE
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  Data: Ras-MAPK inhibition induces AXIN1 loss in colorectal cancer by mTOR associated suppression of protein synthesis.
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  Data: <searchLink fieldCode="AU" term="%22Venkatachalam+N%22">Venkatachalam N</searchLink>; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Muthukumarana+N%22">Muthukumarana N</searchLink>; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.; Division of Biochemistry, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Center for Molecular Biology of Heidelberg University (ZMBH), German Cancer Research Center (DKFZ)-ZMBH Alliance, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Ihnatko+R%22">Ihnatko R</searchLink>; Division of Proteomics of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Krijgsveld+J%22">Krijgsveld J</searchLink>; Division of Proteomics of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Skabkina+O%22">Skabkina O</searchLink>; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Leipertz+A%22">Leipertz A</searchLink>; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Sui+P%22">Sui P</searchLink>; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.; Division of Biochemistry, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Center for Molecular Biology of Heidelberg University (ZMBH), German Cancer Research Center (DKFZ)-ZMBH Alliance, Heidelberg, Germany.; Junior Clinical Cooperation Unit Translational Gastrointestinal Oncology and Preclinical Models, German Cancer Research Center (DKFZ), Heidelberg, Germany.; DKFZ Hector Cancer Institute at University Medical Center Mannheim, Mannheim, Germany.; Mannheim Cancer Center, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Zheng+Q%22">Zheng Q</searchLink>; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Tong+P%22">Tong P</searchLink>; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.; Division of Biochemistry, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Center for Molecular Biology of Heidelberg University (ZMBH), German Cancer Research Center (DKFZ)-ZMBH Alliance, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Descot+A%22">Descot A</searchLink>; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Schewe+M%22">Schewe M</searchLink>; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Diamante+G%22">Diamante G</searchLink>; Cancer Progression and Metastasis Group, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI- STEM gGmbH), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Jackstadt+R%22">Jackstadt R</searchLink>; Cancer Progression and Metastasis Group, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI- STEM gGmbH), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Brochhausen+C%22">Brochhausen C</searchLink>; DKFZ Hector Cancer Institute at University Medical Center Mannheim, Mannheim, Germany.; Institute of Pathology, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Betge+J%22">Betge J</searchLink>; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.; Junior Clinical Cooperation Unit Translational Gastrointestinal Oncology and Preclinical Models, German Cancer Research Center (DKFZ), Heidelberg, Germany.; DKFZ Hector Cancer Institute at University Medical Center Mannheim, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Boonekamp+K%22">Boonekamp K</searchLink>; Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Institute of Human Genetics, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Boutros+M%22">Boutros M</searchLink>; Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Institute of Human Genetics, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Stoecklin+G%22">Stoecklin G</searchLink>; Division of Biochemistry, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Center for Molecular Biology of Heidelberg University (ZMBH), German Cancer Research Center (DKFZ)-ZMBH Alliance, Heidelberg, Germany.; DKFZ Hector Cancer Institute at University Medical Center Mannheim, Mannheim, Germany.; Mannheim Cancer Center, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Ebert+M%22">Ebert M</searchLink>; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.; DKFZ Hector Cancer Institute at University Medical Center Mannheim, Mannheim, Germany.; Mannheim Cancer Center, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Molecular Medicine Partnership Unit, European Molecular Biology Laboratory, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schott+J%22">Schott J</searchLink>; Division of Biochemistry, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Center for Molecular Biology of Heidelberg University (ZMBH), German Cancer Research Center (DKFZ)-ZMBH Alliance, Heidelberg, Germany.; DKFZ Hector Cancer Institute at University Medical Center Mannheim, Mannheim, Germany.; Mannheim Cancer Center, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Zhan+T%22">Zhan T</searchLink>; Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany. tianzuo.zhan@medma.uni-heidelberg.de.; DKFZ Hector Cancer Institute at University Medical Center Mannheim, Mannheim, Germany. tianzuo.zhan@medma.uni-heidelberg.de.; Mannheim Cancer Center, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. tianzuo.zhan@medma.uni-heidelberg.de.; Molecular Medicine Partnership Unit, European Molecular Biology Laboratory, Heidelberg, Germany. tianzuo.zhan@medma.uni-heidelberg.de.
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