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Dual inhibition of KDM4B and KDM5A disassembles the PAX3-FOXO1 transcriptional program in fusion-positive rhabdomyosarcoma.

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Title: Dual inhibition of KDM4B and KDM5A disassembles the PAX3-FOXO1 transcriptional program in fusion-positive rhabdomyosarcoma.
Authors: Yuan J; Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai, 201210, China., Han Q; Shanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China., Ren P; Shanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.; School of Pharmacy, Shanxi Medical University, Taiyuan, 030001, China., Bai F; Shanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.; School of Information Science and Technology, ShanghaiTech University, Shanghai, 201210, China.; Shanghai Clinical Research and Trial Center, Shanghai, 201210, China., Zhang X; Shanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. zhangxl6@shanghaitech.edu.cn., Li K; Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai, 201210, China. likai2727@163.com.
Source: Biology direct [Biol Direct] 2026 May 27; Vol. 21 (1). Date of Electronic Publication: 2026 May 27.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101258412 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6150 (Electronic) Linking ISSN: 17456150 NLM ISO Abbreviation: Biol Direct Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Dual inhibition of KDM4B and KDM5A disassembles the PAX3-FOXO1 transcriptional program in fusion-positive rhabdomyosarcoma.
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  Data: <searchLink fieldCode="AU" term="%22Yuan+J%22">Yuan J</searchLink>; Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai, 201210, China.<br /><searchLink fieldCode="AU" term="%22Han+Q%22">Han Q</searchLink>; Shanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.<br /><searchLink fieldCode="AU" term="%22Ren+P%22">Ren P</searchLink>; Shanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.; School of Pharmacy, Shanxi Medical University, Taiyuan, 030001, China.<br /><searchLink fieldCode="AU" term="%22Bai+F%22">Bai F</searchLink>; Shanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.; School of Information Science and Technology, ShanghaiTech University, Shanghai, 201210, China.; Shanghai Clinical Research and Trial Center, Shanghai, 201210, China.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Shanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. zhangxl6@shanghaitech.edu.cn.<br /><searchLink fieldCode="AU" term="%22Li+K%22">Li K</searchLink>; Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai, 201210, China. likai2727@163.com.
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  Data: <searchLink fieldCode="JN" term="%22101258412%22">Biology direct</searchLink> [Biol Direct] 2026 May 27; Vol. 21 (1). <i>Date of Electronic Publication: </i>2026 May 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101258412 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-6150 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217456150%22">17456150 </searchLink><i>NLM ISO Abbreviation: </i>Biol Direct <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s13062-026-00837-w
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      – TitleFull: Dual inhibition of KDM4B and KDM5A disassembles the PAX3-FOXO1 transcriptional program in fusion-positive rhabdomyosarcoma.
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