Exosomal CircGANAB promotes cancer progression and immunotherapy resistance by degrading interacting RNAs and limiting T cell infiltration in pancreatic ductal adenocarcinoma.

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Title: Exosomal CircGANAB promotes cancer progression and immunotherapy resistance by degrading interacting RNAs and limiting T cell infiltration in pancreatic ductal adenocarcinoma.
Authors: Wong CH; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen 518087, China., Peña-Paladines JJ; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong., Luo Z; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong., Ma CY; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong., Lee YL; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong., Lin ZX; School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong., Xian YF; School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong., Hollingsworth MA; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA., To KF; Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong., Chen Y; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen 518087, China. Electronic address: yangchaochen@cuhk.edu.hk.
Source: Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy [Drug Resist Updat] 2026 Jul; Vol. 87, pp. 101416. Date of Electronic Publication: 2026 May 23.
Publication Type: Journal Article
Journal Info: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 9815369 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2084 (Electronic) Linking ISSN: 13687646 NLM ISO Abbreviation: Drug Resist Updat Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Exosomal CircGANAB promotes cancer progression and immunotherapy resistance by degrading interacting RNAs and limiting T cell infiltration in pancreatic ductal adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Wong+CH%22">Wong CH</searchLink>; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen 518087, China.<br /><searchLink fieldCode="AU" term="%22Peña-Paladines+JJ%22">Peña-Paladines JJ</searchLink>; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Luo+Z%22">Luo Z</searchLink>; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Ma+CY%22">Ma CY</searchLink>; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Lee+YL%22">Lee YL</searchLink>; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Lin+ZX%22">Lin ZX</searchLink>; School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Xian+YF%22">Xian YF</searchLink>; School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Hollingsworth+MA%22">Hollingsworth MA</searchLink>; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.<br /><searchLink fieldCode="AU" term="%22To+KF%22">To KF</searchLink>; Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen 518087, China. Electronic address: yangchaochen@cuhk.edu.hk.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Churchill+Livingstone%22">Churchill Livingstone </searchLink><i>Country of Publication: </i>Scotland <i>NLM ID: </i>9815369 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1532-2084 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213687646%22">13687646 </searchLink><i>NLM ISO Abbreviation: </i>Drug Resist Updat <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.drup.2026.101416
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        Text: English
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              Text: 2026 Jul
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