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Nox4 mediates chondrocyte senescence and cartilage degradation in post-traumatic osteoarthritis via the ROS/p38MAPK signaling pathway.

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Title: Nox4 mediates chondrocyte senescence and cartilage degradation in post-traumatic osteoarthritis via the ROS/p38MAPK signaling pathway.
Authors: Wu Q; Division of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China., Qin H; Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China., Shen K; Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China., Huang D; Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China., Chen J; Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China., Jiang G; Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China., Chen H; Department of Trauma Emergency Center, Ganzhou People's Hospital, Ganzhou, Jiangxi Province, China., Yu B; Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China. Electronic address: yubin@smu.edu.cn., Wang S; Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China. Electronic address: 151102352@qq.com.
Source: International immunopharmacology [Int Immunopharmacol] 2026 Sep 01; Vol. 184, pp. 116924. Date of Electronic Publication: 2026 May 28.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Nox4 mediates chondrocyte senescence and cartilage degradation in post-traumatic osteoarthritis via the ROS/p38MAPK signaling pathway.
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  Data: <searchLink fieldCode="AU" term="%22Wu+Q%22">Wu Q</searchLink>; Division of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.<br /><searchLink fieldCode="AU" term="%22Qin+H%22">Qin H</searchLink>; Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.<br /><searchLink fieldCode="AU" term="%22Shen+K%22">Shen K</searchLink>; Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.<br /><searchLink fieldCode="AU" term="%22Huang+D%22">Huang D</searchLink>; Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.<br /><searchLink fieldCode="AU" term="%22Jiang+G%22">Jiang G</searchLink>; Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Department of Trauma Emergency Center, Ganzhou People's Hospital, Ganzhou, Jiangxi Province, China.<br /><searchLink fieldCode="AU" term="%22Yu+B%22">Yu B</searchLink>; Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China. Electronic address: yubin@smu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China. Electronic address: 151102352@qq.com.
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  Data: <searchLink fieldCode="JN" term="%22100965259%22">International immunopharmacology</searchLink> [Int Immunopharmacol] 2026 Sep 01; Vol. 184, pp. 116924. <i>Date of Electronic Publication: </i>2026 May 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>100965259 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1878-1705 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215675769%22">15675769 </searchLink><i>NLM ISO Abbreviation: </i>Int Immunopharmacol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.intimp.2026.116924
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        Text: English
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              Text: 2026 Sep 01
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