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KMT2D depletion promotes KRAS-induced pancreatic carcinogenesis independent of TP53.

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Title: KMT2D depletion promotes KRAS-induced pancreatic carcinogenesis independent of TP53.
Authors: Tolosa EJ; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA., Raja Arul GL; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA; Molecular Pharmacology and Experimental Therapeutics Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, Minnesota, USA., Sigafoos AN; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA., Ferrero V; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA., Pease DR; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA., Almada LL; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA., Vera RE; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA., Pena Ruiz NM; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA; Molecular Pharmacology and Experimental Therapeutics Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, Minnesota, USA., Hogenson TL; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA., LaRue-Nolan KC; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA; Molecular Pharmacology and Experimental Therapeutics Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, Minnesota, USA., Tader BR; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA., Graham RP; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA., Brown M; Division of Endocrinology, Metabolism, Diabetes, and Nutrition, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA., Hagen CE; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA., Matveyenko AV; Division of Endocrinology, Metabolism, Diabetes, and Nutrition, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA., Carr RM; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA., Ge K; National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA., Fernandez-Zapico ME; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA. Electronic address: FernandezZapico.Martin@mayo.edu.
Source: The Journal of biological chemistry [J Biol Chem] 2026 May 27; Vol. 302 (7), pp. 113203. Date of Electronic Publication: 2026 May 27.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: KMT2D depletion promotes KRAS-induced pancreatic carcinogenesis independent of TP53.
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  Data: <searchLink fieldCode="AU" term="%22Tolosa+EJ%22">Tolosa EJ</searchLink>; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Raja+Arul+GL%22">Raja Arul GL</searchLink>; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA; Molecular Pharmacology and Experimental Therapeutics Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Sigafoos+AN%22">Sigafoos AN</searchLink>; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Ferrero+V%22">Ferrero V</searchLink>; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Pease+DR%22">Pease DR</searchLink>; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Almada+LL%22">Almada LL</searchLink>; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Vera+RE%22">Vera RE</searchLink>; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Pena+Ruiz+NM%22">Pena Ruiz NM</searchLink>; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA; Molecular Pharmacology and Experimental Therapeutics Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Hogenson+TL%22">Hogenson TL</searchLink>; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22LaRue-Nolan+KC%22">LaRue-Nolan KC</searchLink>; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA; Molecular Pharmacology and Experimental Therapeutics Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Tader+BR%22">Tader BR</searchLink>; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Graham+RP%22">Graham RP</searchLink>; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Brown+M%22">Brown M</searchLink>; Division of Endocrinology, Metabolism, Diabetes, and Nutrition, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Hagen+CE%22">Hagen CE</searchLink>; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Matveyenko+AV%22">Matveyenko AV</searchLink>; Division of Endocrinology, Metabolism, Diabetes, and Nutrition, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Carr+RM%22">Carr RM</searchLink>; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Ge+K%22">Ge K</searchLink>; National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Fernandez-Zapico+ME%22">Fernandez-Zapico ME</searchLink>; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA. Electronic address: FernandezZapico.Martin@mayo.edu.
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  Data: <searchLink fieldCode="JN" term="%222985121R%22">The Journal of biological chemistry</searchLink> [J Biol Chem] 2026 May 27; Vol. 302 (7), pp. 113203. <i>Date of Electronic Publication: </i>2026 May 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%2E+on+behalf+of+American+Society+for+Biochemistry+and+Molecular+Biology%22">Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2985121R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1083-351X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219258%22">00219258 </searchLink><i>NLM ISO Abbreviation: </i>J Biol Chem <i>Subsets: </i>MEDLINE
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      – TitleFull: KMT2D depletion promotes KRAS-induced pancreatic carcinogenesis independent of TP53.
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