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Pharmacokinetic profiling of imatinib in relation to CYP3A4 activity in leukaemia patients.

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Title: Pharmacokinetic profiling of imatinib in relation to CYP3A4 activity in leukaemia patients.
Authors: Rasmussen ASB; Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Pediatric Oncology Research Laboratory, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Koch MR; Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Pediatric Oncology Research Laboratory, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Rank CU; Department of Hematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Andersen CL; Department of Hematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Research Unit for General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Weimann A; Pediatric Oncology Research Laboratory, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Thastrup M; Pediatric Oncology Research Laboratory, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Yang T; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Lund TM; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Christensen IJ; Molecular Unit, Department of Pathology, Copenhagen University Hospital, Herlev and Gentofte Hospital, Herlev, Denmark., Nielsen F; Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark., Stage TB; Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark., Jensen SB; Department of Clinical Genetics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Andersen MK; Department of Clinical Genetics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Schmiegelow K; Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Pediatric Oncology Research Laboratory, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Institute of Clinical Medicine, Faculty of Medicine, University of Copenhagen, Copenhagen, Denmark., Dalhoff K; Institute of Clinical Medicine, Faculty of Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Pharmacology, Copenhagen University Hospital, Copenhagen, Denmark.
Source: British journal of clinical pharmacology [Br J Clin Pharmacol] 2026 May 28. Date of Electronic Publication: 2026 May 28.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7503323 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2125 (Electronic) Linking ISSN: 03065251 NLM ISO Abbreviation: Br J Clin Pharmacol Subsets: MEDLINE
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  Data: Pharmacokinetic profiling of imatinib in relation to CYP3A4 activity in leukaemia patients.
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  Data: <searchLink fieldCode="AU" term="%22Rasmussen+ASB%22">Rasmussen ASB</searchLink>; Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Pediatric Oncology Research Laboratory, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Koch+MR%22">Koch MR</searchLink>; Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Pediatric Oncology Research Laboratory, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Rank+CU%22">Rank CU</searchLink>; Department of Hematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Andersen+CL%22">Andersen CL</searchLink>; Department of Hematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Research Unit for General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Weimann+A%22">Weimann A</searchLink>; Pediatric Oncology Research Laboratory, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Thastrup+M%22">Thastrup M</searchLink>; Pediatric Oncology Research Laboratory, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Yang+T%22">Yang T</searchLink>; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Lund+TM%22">Lund TM</searchLink>; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Christensen+IJ%22">Christensen IJ</searchLink>; Molecular Unit, Department of Pathology, Copenhagen University Hospital, Herlev and Gentofte Hospital, Herlev, Denmark.<br /><searchLink fieldCode="AU" term="%22Nielsen+F%22">Nielsen F</searchLink>; Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Stage+TB%22">Stage TB</searchLink>; Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Jensen+SB%22">Jensen SB</searchLink>; Department of Clinical Genetics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Andersen+MK%22">Andersen MK</searchLink>; Department of Clinical Genetics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Schmiegelow+K%22">Schmiegelow K</searchLink>; Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Pediatric Oncology Research Laboratory, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Institute of Clinical Medicine, Faculty of Medicine, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Dalhoff+K%22">Dalhoff K</searchLink>; Institute of Clinical Medicine, Faculty of Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Pharmacology, Copenhagen University Hospital, Copenhagen, Denmark.
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