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Enhancing anandamide signalling through fatty acid amide hydrolase inhibition: An update on the pharmacological strategy for treating psychiatric disorders.

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Title: Enhancing anandamide signalling through fatty acid amide hydrolase inhibition: An update on the pharmacological strategy for treating psychiatric disorders.
Authors: Couttas TA; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Neuroscience Research Australia, Randwick, NSW, Australia.; Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia., Hoffmann AE; Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.; Endosane® Pharmaceuticals GmbH, Berlin, Germany., Jieu B; Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia., Golla FR; Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.; Endosane® Pharmaceuticals GmbH, Berlin, Germany., Shepherd CE; Neuroscience Research Australia, Randwick, NSW, Australia., Leweke FM; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. markus.leweke@zi-mannheim.de.; Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. markus.leweke@zi-mannheim.de., Rohleder C; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.; Endosane® Pharmaceuticals GmbH, Berlin, Germany.
Source: Translational psychiatry [Transl Psychiatry] 2026 May 28; Vol. 16 (1). Date of Electronic Publication: 2026 May 28.
Publication Type: Journal Article; Review
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Couttas+TA%22">Couttas TA</searchLink>; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Neuroscience Research Australia, Randwick, NSW, Australia.; Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Hoffmann+AE%22">Hoffmann AE</searchLink>; Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.; Endosane® Pharmaceuticals GmbH, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Jieu+B%22">Jieu B</searchLink>; Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Golla+FR%22">Golla FR</searchLink>; Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.; Endosane® Pharmaceuticals GmbH, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Shepherd+CE%22">Shepherd CE</searchLink>; Neuroscience Research Australia, Randwick, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Leweke+FM%22">Leweke FM</searchLink>; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. markus.leweke@zi-mannheim.de.; Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. markus.leweke@zi-mannheim.de.<br /><searchLink fieldCode="AU" term="%22Rohleder+C%22">Rohleder C</searchLink>; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.; Endosane® Pharmaceuticals GmbH, Berlin, Germany.
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              Text: 2026 May 28
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