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Disruption of ER-mitochondria contact sites by coronavirus replication organelles sustains viral replication via NSP3 stabilization.

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Title: Disruption of ER-mitochondria contact sites by coronavirus replication organelles sustains viral replication via NSP3 stabilization.
Authors: Zheng X; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.; Guangzhou National Laboratory, Guangzhou, China., Hu L; Guangzhou National Laboratory, Guangzhou, China., Long X; Guangzhou National Laboratory, Guangzhou, China.; The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China., Zhao Z; Guangzhou National Laboratory, Guangzhou, China., Chen R; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China., Bai R; Guangzhou National Laboratory, Guangzhou, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China., Tian B; Guangzhou National Laboratory, Guangzhou, China.; The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China., Zhou M; Guangzhou National Laboratory, Guangzhou, China. zhou_maoge@gzlab.ac.cn., Ding B; Guangzhou National Laboratory, Guangzhou, China. dingbinbin1988@163.com., Xu T; Guangzhou National Laboratory, Guangzhou, China. xutao@ibp.ac.cn.; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. xutao@ibp.ac.cn., Li Z; Guangzhou National Laboratory, Guangzhou, China. li_zonghong@gzlab.ac.cn.; The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China. li_zonghong@gzlab.ac.cn.
Source: The EMBO journal [EMBO J] 2026 Jul; Vol. 45 (13), pp. 4379-4416. Date of Electronic Publication: 2026 May 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Disruption of ER-mitochondria contact sites by coronavirus replication organelles sustains viral replication via NSP3 stabilization.
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  Data: <searchLink fieldCode="AU" term="%22Zheng+X%22">Zheng X</searchLink>; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.; Guangzhou National Laboratory, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Hu+L%22">Hu L</searchLink>; Guangzhou National Laboratory, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Long+X%22">Long X</searchLink>; Guangzhou National Laboratory, Guangzhou, China.; The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhao+Z%22">Zhao Z</searchLink>; Guangzhou National Laboratory, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+R%22">Chen R</searchLink>; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Bai+R%22">Bai R</searchLink>; Guangzhou National Laboratory, Guangzhou, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Tian+B%22">Tian B</searchLink>; Guangzhou National Laboratory, Guangzhou, China.; The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhou+M%22">Zhou M</searchLink>; Guangzhou National Laboratory, Guangzhou, China. zhou_maoge@gzlab.ac.cn.<br /><searchLink fieldCode="AU" term="%22Ding+B%22">Ding B</searchLink>; Guangzhou National Laboratory, Guangzhou, China. dingbinbin1988@163.com.<br /><searchLink fieldCode="AU" term="%22Xu+T%22">Xu T</searchLink>; Guangzhou National Laboratory, Guangzhou, China. xutao@ibp.ac.cn.; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. xutao@ibp.ac.cn.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Guangzhou National Laboratory, Guangzhou, China. li_zonghong@gzlab.ac.cn.; The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China. li_zonghong@gzlab.ac.cn.
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  Data: <searchLink fieldCode="JN" term="%228208664%22">The EMBO journal</searchLink> [EMBO J] 2026 Jul; Vol. 45 (13), pp. 4379-4416. <i>Date of Electronic Publication: </i>2026 May 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8208664 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1460-2075 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202614189%22">02614189 </searchLink><i>NLM ISO Abbreviation: </i>EMBO J <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42209846
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        Value: 10.1038/s44318-026-00816-x
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              Text: 2026 Jul
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