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CircSPARC promotes esophageal squamous cell carcinoma through an HNRNPC-EPN2 splicing axis that activates Wnt/β-Catenin signaling.

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Title: CircSPARC promotes esophageal squamous cell carcinoma through an HNRNPC-EPN2 splicing axis that activates Wnt/β-Catenin signaling.
Authors: Dai S; Research Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China.; Key Laboratory of Tumor Prevention and Precision Diagnosis and Treatment of Hebei, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China., Zhang C; Research Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China.; Key Laboratory of Tumor Prevention and Precision Diagnosis and Treatment of Hebei, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China., Wei Z; Research Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China.; Key Laboratory of Tumor Prevention and Precision Diagnosis and Treatment of Hebei, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China., Liu Y; Research Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China.; Key Laboratory of Tumor Prevention and Precision Diagnosis and Treatment of Hebei, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China., Wen Y; Research Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China.; Department of Chemoradiotherapy, Affiliated Hospital of North China University of Science and Technology, Tangshan, Hebei, 063000, China., Chen J; Department of Blood Transfusion, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China., Li X; Research Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China.; Key Laboratory of Tumor Prevention and Precision Diagnosis and Treatment of Hebei, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China., Wei S; Research Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China.; Key Laboratory of Tumor Prevention and Precision Diagnosis and Treatment of Hebei, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China., Sun G; Department of Chemoradiotherapy, Affiliated Hospital of North China University of Science and Technology, Tangshan, Hebei, 063000, China. sunguogui@ncst.edu.cn., Zhao L; Research Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China. lianmei555@hebmu.edu.cn.; Key Laboratory of Tumor Prevention and Precision Diagnosis and Treatment of Hebei, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China. lianmei555@hebmu.edu.cn.
Source: Molecular cancer [Mol Cancer] 2026 May 28; Vol. 25 (1). Date of Electronic Publication: 2026 May 28.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598 (Electronic) Linking ISSN: 14764598 NLM ISO Abbreviation: Mol Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: CircSPARC promotes esophageal squamous cell carcinoma through an HNRNPC-EPN2 splicing axis that activates Wnt/β-Catenin signaling.
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  Data: <searchLink fieldCode="AU" term="%22Dai+S%22">Dai S</searchLink>; Research Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China.; Key Laboratory of Tumor Prevention and Precision Diagnosis and Treatment of Hebei, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China.<br /><searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; Research Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China.; Key Laboratory of Tumor Prevention and Precision Diagnosis and Treatment of Hebei, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China.<br /><searchLink fieldCode="AU" term="%22Wei+Z%22">Wei Z</searchLink>; Research Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China.; Key Laboratory of Tumor Prevention and Precision Diagnosis and Treatment of Hebei, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Research Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China.; Key Laboratory of Tumor Prevention and Precision Diagnosis and Treatment of Hebei, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China.<br /><searchLink fieldCode="AU" term="%22Wen+Y%22">Wen Y</searchLink>; Research Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China.; Department of Chemoradiotherapy, Affiliated Hospital of North China University of Science and Technology, Tangshan, Hebei, 063000, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of Blood Transfusion, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Research Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China.; Key Laboratory of Tumor Prevention and Precision Diagnosis and Treatment of Hebei, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China.<br /><searchLink fieldCode="AU" term="%22Wei+S%22">Wei S</searchLink>; Research Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China.; Key Laboratory of Tumor Prevention and Precision Diagnosis and Treatment of Hebei, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China.<br /><searchLink fieldCode="AU" term="%22Sun+G%22">Sun G</searchLink>; Department of Chemoradiotherapy, Affiliated Hospital of North China University of Science and Technology, Tangshan, Hebei, 063000, China. sunguogui@ncst.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhao+L%22">Zhao L</searchLink>; Research Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China. lianmei555@hebmu.edu.cn.; Key Laboratory of Tumor Prevention and Precision Diagnosis and Treatment of Hebei, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China. lianmei555@hebmu.edu.cn.
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        Value: 10.1186/s12943-026-02691-w
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      – TitleFull: CircSPARC promotes esophageal squamous cell carcinoma through an HNRNPC-EPN2 splicing axis that activates Wnt/β-Catenin signaling.
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            – D: 28
              M: 05
              Text: 2026 May 28
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