Huaier Polysaccharides Sensitize Anti-PD-L1 Therapy via Promoting Antitumor Immune Response in Triple-Negative Breast Cancer.

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Title: Huaier Polysaccharides Sensitize Anti-PD-L1 Therapy via Promoting Antitumor Immune Response in Triple-Negative Breast Cancer.
Authors: Zhou LX; Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China.; Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Wu ZW; Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China., Tian Y; Department of Breast Surgery, Linyi People's Hospital, Linyi, China., Luo KF; Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China.; Department of Breast and Thyroid Surgery/Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis and Treatment of Breast Cancer, Southwest Hospital, Army Medical University, Chongqing, China., Pan QW; Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China.; Department of Breast and Thyroid Surgery/Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis and Treatment of Breast Cancer, Southwest Hospital, Army Medical University, Chongqing, China., Xi YY; Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China., Tang P; Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China.; Department of Breast and Thyroid Surgery/Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis and Treatment of Breast Cancer, Southwest Hospital, Army Medical University, Chongqing, China., Zeng LJ; Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China.; Department of Breast and Thyroid Surgery/Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis and Treatment of Breast Cancer, Southwest Hospital, Army Medical University, Chongqing, China., Zhong L; Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China.; Department of Breast and Thyroid Surgery/Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis and Treatment of Breast Cancer, Southwest Hospital, Army Medical University, Chongqing, China., Jiang J; Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China.; Department of Breast and Thyroid Surgery/Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis and Treatment of Breast Cancer, Southwest Hospital, Army Medical University, Chongqing, China., Zhang Y; Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China.; Department of Breast and Thyroid Surgery/Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis and Treatment of Breast Cancer, Southwest Hospital, Army Medical University, Chongqing, China., Hou L; Department of Breast Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China., Zheng H; Department of Thoracic Surgery, Xinqiao Hospital, Army Medical University, Chongqing, China., Wang MH; Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China.; Department of Breast and Thyroid Surgery/Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis and Treatment of Breast Cancer, Southwest Hospital, Army Medical University, Chongqing, China.
Source: International journal of biological sciences [Int J Biol Sci] 2026 May 18; Vol. 22 (10), pp. 5509-5524. Date of Electronic Publication: 2026 May 18 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Country of Publication: Australia NLM ID: 101235568 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-2288 (Electronic) Linking ISSN: 14492288 NLM ISO Abbreviation: Int J Biol Sci Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Zhou+LX%22">Zhou LX</searchLink>; Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China.; Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wu+ZW%22">Wu ZW</searchLink>; Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Tian+Y%22">Tian Y</searchLink>; Department of Breast Surgery, Linyi People's Hospital, Linyi, China.<br /><searchLink fieldCode="AU" term="%22Luo+KF%22">Luo KF</searchLink>; Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China.; Department of Breast and Thyroid Surgery/Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis and Treatment of Breast Cancer, Southwest Hospital, Army Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Pan+QW%22">Pan QW</searchLink>; Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China.; Department of Breast and Thyroid Surgery/Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis and Treatment of Breast Cancer, Southwest Hospital, Army Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Xi+YY%22">Xi YY</searchLink>; Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Tang+P%22">Tang P</searchLink>; Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China.; Department of Breast and Thyroid Surgery/Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis and Treatment of Breast Cancer, Southwest Hospital, Army Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Zeng+LJ%22">Zeng LJ</searchLink>; Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China.; Department of Breast and Thyroid Surgery/Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis and Treatment of Breast Cancer, Southwest Hospital, Army Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Zhong+L%22">Zhong L</searchLink>; Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China.; Department of Breast and Thyroid Surgery/Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis and Treatment of Breast Cancer, Southwest Hospital, Army Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Jiang+J%22">Jiang J</searchLink>; Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China.; Department of Breast and Thyroid Surgery/Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis and Treatment of Breast Cancer, Southwest Hospital, Army Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China.; Department of Breast and Thyroid Surgery/Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis and Treatment of Breast Cancer, Southwest Hospital, Army Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Hou+L%22">Hou L</searchLink>; Department of Breast Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Zheng+H%22">Zheng H</searchLink>; Department of Thoracic Surgery, Xinqiao Hospital, Army Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Wang+MH%22">Wang MH</searchLink>; Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China.; Department of Breast and Thyroid Surgery/Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis and Treatment of Breast Cancer, Southwest Hospital, Army Medical University, Chongqing, China.
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  Data: <searchLink fieldCode="JN" term="%22101235568%22">International journal of biological sciences</searchLink> [Int J Biol Sci] 2026 May 18; Vol. 22 (10), pp. 5509-5524. <i>Date of Electronic Publication: </i>2026 May 18 (<i>Print Publication: </i>2026).
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        Value: 10.7150/ijbs.133068
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      – TitleFull: Huaier Polysaccharides Sensitize Anti-PD-L1 Therapy via Promoting Antitumor Immune Response in Triple-Negative Breast Cancer.
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