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Reprogramming Transcriptional Networks via CREB1 Lactylation at K122 Activates HMGB1-Mediated NETosis and Chemoresistance.

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Title: Reprogramming Transcriptional Networks via CREB1 Lactylation at K122 Activates HMGB1-Mediated NETosis and Chemoresistance.
Authors: Wang JM; Department of Biochemistry and Molecular Biology, China Medical University, Shenyang, 110122, China.; Department of Laboratory Medicine, The First Hospital of China Medical University, Shenyang, 110001, China., Zhao FY; Department of Biochemistry and Molecular Biology, China Medical University, Shenyang, 110122, China., Zhang Q; Department of Biochemistry and Molecular Biology, China Medical University, Shenyang, 110122, China.; Department of University Hospital, Criminal Investigation Police University of China, Shenyang, 110854, China., Yuan Y; Central Laboratory, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Cancer Hospital of Dalian University of Technology, Shenyang 110042, China., Li BQ; Department of Biochemistry and Molecular Biology, China Medical University, Shenyang, 110122, China., Liu N; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang, Liaoning Province 110004, China., Li JJ; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang, Liaoning Province 110004, China., Liu C; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang, Liaoning Province 110004, China., Wang HQ; Department of Biochemistry and Molecular Biology, China Medical University, Shenyang, 110122, China.
Source: International journal of biological sciences [Int J Biol Sci] 2026 May 18; Vol. 22 (10), pp. 5568-5594. Date of Electronic Publication: 2026 May 18 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Country of Publication: Australia NLM ID: 101235568 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-2288 (Electronic) Linking ISSN: 14492288 NLM ISO Abbreviation: Int J Biol Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Reprogramming Transcriptional Networks via CREB1 Lactylation at K122 Activates HMGB1-Mediated NETosis and Chemoresistance.
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  Data: <searchLink fieldCode="AU" term="%22Wang+JM%22">Wang JM</searchLink>; Department of Biochemistry and Molecular Biology, China Medical University, Shenyang, 110122, China.; Department of Laboratory Medicine, The First Hospital of China Medical University, Shenyang, 110001, China.<br /><searchLink fieldCode="AU" term="%22Zhao+FY%22">Zhao FY</searchLink>; Department of Biochemistry and Molecular Biology, China Medical University, Shenyang, 110122, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; Department of Biochemistry and Molecular Biology, China Medical University, Shenyang, 110122, China.; Department of University Hospital, Criminal Investigation Police University of China, Shenyang, 110854, China.<br /><searchLink fieldCode="AU" term="%22Yuan+Y%22">Yuan Y</searchLink>; Central Laboratory, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Cancer Hospital of Dalian University of Technology, Shenyang 110042, China.<br /><searchLink fieldCode="AU" term="%22Li+BQ%22">Li BQ</searchLink>; Department of Biochemistry and Molecular Biology, China Medical University, Shenyang, 110122, China.<br /><searchLink fieldCode="AU" term="%22Liu+N%22">Liu N</searchLink>; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang, Liaoning Province 110004, China.<br /><searchLink fieldCode="AU" term="%22Li+JJ%22">Li JJ</searchLink>; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang, Liaoning Province 110004, China.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang, Liaoning Province 110004, China.<br /><searchLink fieldCode="AU" term="%22Wang+HQ%22">Wang HQ</searchLink>; Department of Biochemistry and Molecular Biology, China Medical University, Shenyang, 110122, China.
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  Data: <searchLink fieldCode="JN" term="%22101235568%22">International journal of biological sciences</searchLink> [Int J Biol Sci] 2026 May 18; Vol. 22 (10), pp. 5568-5594. <i>Date of Electronic Publication: </i>2026 May 18 (<i>Print Publication: </i>2026).
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              Text: 2026 May 18
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