Developing Predictive Models by Sharing Predictions - An Investigation of a Federated Learning Approach for ADMET Predictions.
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| Title: | Developing Predictive Models by Sharing Predictions - An Investigation of a Federated Learning Approach for ADMET Predictions. |
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| Authors: | Guha R; Vertex Pharmaceuticals, 50 Northern Avenue, Boston, Massachusetts 02129, United States., Wang W; Drug Metabolism & Pharmacokinetics (DMPK), Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Price E; Quantitative, Translational & ADME Sciences, AbbVie Inc., North Chicago, Illinois 60064, United States., Bhhatarai B; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Hassan M; Quantitative, Translational & ADME Sciences, AbbVie Inc., North Chicago, Illinois 60064, United States., DiFranzo A; Medical Analytics Center, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Keefer C; Translational Modeling and Simulation, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Woody N; Translational Modeling and Simulation, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Broccatelli F; Drug Metabolism & Pharmacokinetics (DMPK), Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Winiwarter S; Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Mölndal 431 83, Sweden., He L; Daiichi Sankyo, Inc, 211 Mt. Airy Road, Basking Ridge, New Jersey 07920, United States., Green DVS; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Edwards CD; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Kato H; DMPK Research Laboratories, Mitsubishi Tanabe Pharma Corporation, Yokohama, Kanagawa 227-0033, Japan., Kosugi Y; DMPK & Modeling, Takeda Pharmaceutical Company Limited, 26-1 Muraoka-Higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan., Desai P; Drug Metabolism & Pharmacokinetics (DMPK), Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2026 Jun 11; Vol. 69 (11), pp. 12973-12981. Date of Electronic Publication: 2026 May 29. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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