Structure-based design and synthesis of group A streptogramins that bind to the nascent peptide exit tunnel of the ribosome.
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| Title: | Structure-based design and synthesis of group A streptogramins that bind to the nascent peptide exit tunnel of the ribosome. |
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| Authors: | Lee IJ; Department of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California - San Francisco, San Francisco, California, 94158, United States., Li Q; Department of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California - San Francisco, San Francisco, California, 94158, United States; Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai, 201203, China., Raskar T; Department of Bioengineering and Therapeutic Sciences, University of California - San Francisco, San Francisco, California, 94158, United States., Pellegrino J; Department of Bioengineering and Therapeutic Sciences, University of California - San Francisco, San Francisco, California, 94158, United States., Ecker AK; Department of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California - San Francisco, San Francisco, California, 94158, United States; Department of Chemistry, The Scripps Research Institute, La Jolla, California, 92307, United States., Howard SY; Department of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California - San Francisco, San Francisco, California, 94158, United States., Fraser JS; Department of Bioengineering and Therapeutic Sciences, University of California - San Francisco, San Francisco, California, 94158, United States., Seiple IB; Department of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California - San Francisco, San Francisco, California, 94158, United States; Department of Chemistry, The Scripps Research Institute, La Jolla, California, 92307, United States. Electronic address: iseiple@scripps.edu. |
| Source: | European journal of medicinal chemistry [Eur J Med Chem] 2026 Oct 15; Vol. 316, pp. 118947. Date of Electronic Publication: 2026 May 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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