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Updated Results of the POSITIVE (Pregnancy Outcome and Safety of Interrupting Therapy for Women with Endocrine Responsive Breast Cancer) Trial.

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Title: Updated Results of the POSITIVE (Pregnancy Outcome and Safety of Interrupting Therapy for Women with Endocrine Responsive Breast Cancer) Trial.
Authors: Pagani O; Geneva University Hospitals, Geneva, Switzerland; University Hospitals, Lugano University, Lugano, Switzerland; Swiss Cancer Institute (formerly SAKK), Bern, Switzerland., Niman SM; International Breast Cancer Study Group Statistical Center, Boston, MA, USA; Department of Data Science, Division of Biostatistics, Dana-Farber Cancer Institute, Boston, MA, USA., Ruggeri M; Program for Young Patients, International Breast Cancer Study Group, a division of ETOP IBCSG Partners Foundation, Bern, Switzerland., Peccatori FA; Fertility and Procreation Unit, Gynecologic Oncology Program, IEO, European Institute of Oncology IRCCS, Milan, Italy., Azim HA Jr; Cairo Cure Oncology Center, Cairo, Egypt., Colleoni M; Division of Medical Senology, IEO, European Institute of Oncology, IRCCS, Milan, Italy., Saura C; Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology, Barcelona, Spain; SOLTI Breast Cancer Research Group, Barcelona, Spain., Shimizu C; Department of Breast and Medical Oncology, Japan Institute of Health Security - National Center for Global Health and Medicine, Toyama, Shinjuku-ku, Tokyo, Japan., Sætersdal AB; Breast Cancer Unit, Department of Oncology, Division of Cancer Medicine, Oslo University Hospital, Oslo, Norway., Kroep JR; Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands; Dutch Breast Cancer Group, BOOG, Utrecht, the Netherlands., Warner E; Odette Cancer Center, Sunnybrook Health Sciences Center, Toronto, Canada., Amant F; Department of Oncology, KU Leuven and Leuven Cancer Institute, Leuven, Belgium; Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium; Antoni van Leeuwenhoek-Netherlands Cancer Institute, Amsterdam, The Netherlands., Mailliez A; Department of Medical Oncology, Centre Oscar Lambret, Lille, France., Moore HCF; Breast Oncology Program, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, USA., Ruiz-Borrego M; GEICAM Spanish Breast Cancer Group, Madrid, Spain; Hospital Virgen del Rocio Sevilla, Sevilla, Spain., Walshe JM; Cancer Trials Ireland, Dublin, Ireland; Department of Medical Oncology, St. Vincent's University Hospital, Dublin, Ireland., Borges VF; Division of Medical Oncology, Department of Medicine, University of Colorado Cancer Center, Aurora, Colorado, USA., Gombos A; Institut Jules Bordet and Université Libre de Bruxelles, Brussels, Belgium., Kataoka A; Breast Oncology Center, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan., Rousset-Jablonski C; Department of Surgery, Leon Berard Cancer Centre, Centre Léon Bérard, Lyon, France; INSERM U1290 RESHAPE, Lyon, France; Gynecology and Obstetrics Department, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Bron, France., Borstnar S; Division of Medical Oncology, Institute of Oncology, Ljubljana, Slovenia; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia., Takei J; St Luke's International Hospital, Breast Center, Tokyo, Japan., Lee JE; Breast Division, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Clinical Research and Evaluation, SAIHST, Sungkyunkwan University, Seoul, South Korea., Saunders C; Department of Surgery, University of Melbourne, Melbourne, VIC, Australia; Royal Melbourne Hospital, Melbourne, VIC, Australia., Bjelic-Radisic V; Breast Unit, Helios University Clinic Wuppertal, University Witten/Herdecke, Wuppertal, Germany; Austrian Breast and Colorectal Study Group (ABCSG), Austria., Susnjar S; Department of Medical Oncology, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia., Cardoso F; Breast Unit, Champalimaud Clinical Center/Champalimaud Foundation, and Advanced Breast Cancer (ABC) Global Alliance Lisbon, Portugal., Klar NJ; New York University Langone's Perlmutter Cancer Center, Breast Cancer Center, New York, NY, USA., Ferreiro T; Soul Reconnect, Barcelona, Spain., Ribi K; International Breast Cancer Study Group (IBCSG), a division of ETOP (European Thoracic Oncology Platform) IBCSG Partners Foundation, Bern, Switzerland; Careum School of Health, Part of the Kalaidos University of Applied Sciences, Zurich, Switzerland., Ruddy KJ; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Kammler R; Translational Research Coordination, International Breast Cancer Study Group, a division of ETOP IBCSG Partners Foundation, Bern, Switzerland., El-Abed S; Breast International Group (BIG), Brussels, Belgium., Viale G; International Breast Cancer Study Group Central Pathology Office, Bern, Switzerland; Department of Pathology and Laboratory Medicine, IEO, European Institute of Oncology, IRCCS, Milan, Italy., Piccart M; Institut Jules Bordet and Université Libre de Bruxelles, Brussels, Belgium; Breast International Group (BIG), Brussels, Belgium., Korde LA; Jazz Pharmaceuticals, USA., Goldhirsch A; International Breast Cancer Study Group, Division of ETOP IBCSG Partners Foundation, Bern, Switzerland; IEO, European Institute of Oncology, IRCCS, Milan, Italy., Gelber RD; International Breast Cancer Study Group Statistical Center, Boston, MA, USA; Department of Data Science, Division of Biostatistics, Dana-Farber Cancer Institute, Boston, MA, USA; Frontier Science and Technology Research Foundation, Boston, MA USA; Harvard TH Chan School of Public Health, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Partridge AH; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Corporate Authors: International Breast Cancer Study Group, POSITIVE Trial Consortium
Source: Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2026 May 28. Date of Electronic Publication: 2026 May 28.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 9007735 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1569-8041 (Electronic) Linking ISSN: 09237534 NLM ISO Abbreviation: Ann Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Updated Results of the POSITIVE (Pregnancy Outcome and Safety of Interrupting Therapy for Women with Endocrine Responsive Breast Cancer) Trial.
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  Data: <searchLink fieldCode="AU" term="%22Pagani+O%22">Pagani O</searchLink>; Geneva University Hospitals, Geneva, Switzerland; University Hospitals, Lugano University, Lugano, Switzerland; Swiss Cancer Institute (formerly SAKK), Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Niman+SM%22">Niman SM</searchLink>; International Breast Cancer Study Group Statistical Center, Boston, MA, USA; Department of Data Science, Division of Biostatistics, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ruggeri+M%22">Ruggeri M</searchLink>; Program for Young Patients, International Breast Cancer Study Group, a division of ETOP IBCSG Partners Foundation, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Peccatori+FA%22">Peccatori FA</searchLink>; Fertility and Procreation Unit, Gynecologic Oncology Program, IEO, European Institute of Oncology IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Azim+HA+Jr%22">Azim HA Jr</searchLink>; Cairo Cure Oncology Center, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Colleoni+M%22">Colleoni M</searchLink>; Division of Medical Senology, IEO, European Institute of Oncology, IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Saura+C%22">Saura C</searchLink>; Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology, Barcelona, Spain; SOLTI Breast Cancer Research Group, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Shimizu+C%22">Shimizu C</searchLink>; Department of Breast and Medical Oncology, Japan Institute of Health Security - National Center for Global Health and Medicine, Toyama, Shinjuku-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Sætersdal+AB%22">Sætersdal AB</searchLink>; Breast Cancer Unit, Department of Oncology, Division of Cancer Medicine, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Kroep+JR%22">Kroep JR</searchLink>; Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands; Dutch Breast Cancer Group, BOOG, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Warner+E%22">Warner E</searchLink>; Odette Cancer Center, Sunnybrook Health Sciences Center, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Amant+F%22">Amant F</searchLink>; Department of Oncology, KU Leuven and Leuven Cancer Institute, Leuven, Belgium; Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium; Antoni van Leeuwenhoek-Netherlands Cancer Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Mailliez+A%22">Mailliez A</searchLink>; Department of Medical Oncology, Centre Oscar Lambret, Lille, France.<br /><searchLink fieldCode="AU" term="%22Moore+HCF%22">Moore HCF</searchLink>; Breast Oncology Program, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Ruiz-Borrego+M%22">Ruiz-Borrego M</searchLink>; GEICAM Spanish Breast Cancer Group, Madrid, Spain; Hospital Virgen del Rocio Sevilla, Sevilla, Spain.<br /><searchLink fieldCode="AU" term="%22Walshe+JM%22">Walshe JM</searchLink>; Cancer Trials Ireland, Dublin, Ireland; Department of Medical Oncology, St. Vincent's University Hospital, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Borges+VF%22">Borges VF</searchLink>; Division of Medical Oncology, Department of Medicine, University of Colorado Cancer Center, Aurora, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Gombos+A%22">Gombos A</searchLink>; Institut Jules Bordet and Université Libre de Bruxelles, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Kataoka+A%22">Kataoka A</searchLink>; Breast Oncology Center, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Rousset-Jablonski+C%22">Rousset-Jablonski C</searchLink>; Department of Surgery, Leon Berard Cancer Centre, Centre Léon Bérard, Lyon, France; INSERM U1290 RESHAPE, Lyon, France; Gynecology and Obstetrics Department, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Bron, France.<br /><searchLink fieldCode="AU" term="%22Borstnar+S%22">Borstnar S</searchLink>; Division of Medical Oncology, Institute of Oncology, Ljubljana, Slovenia; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.<br /><searchLink fieldCode="AU" term="%22Takei+J%22">Takei J</searchLink>; St Luke's International Hospital, Breast Center, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Lee+JE%22">Lee JE</searchLink>; Breast Division, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Clinical Research and Evaluation, SAIHST, Sungkyunkwan University, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Saunders+C%22">Saunders C</searchLink>; Department of Surgery, University of Melbourne, Melbourne, VIC, Australia; Royal Melbourne Hospital, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Bjelic-Radisic+V%22">Bjelic-Radisic V</searchLink>; Breast Unit, Helios University Clinic Wuppertal, University Witten/Herdecke, Wuppertal, Germany; Austrian Breast and Colorectal Study Group (ABCSG), Austria.<br /><searchLink fieldCode="AU" term="%22Susnjar+S%22">Susnjar S</searchLink>; Department of Medical Oncology, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.<br /><searchLink fieldCode="AU" term="%22Cardoso+F%22">Cardoso F</searchLink>; Breast Unit, Champalimaud Clinical Center/Champalimaud Foundation, and Advanced Breast Cancer (ABC) Global Alliance Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Klar+NJ%22">Klar NJ</searchLink>; New York University Langone's Perlmutter Cancer Center, Breast Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ferreiro+T%22">Ferreiro T</searchLink>; Soul Reconnect, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Ribi+K%22">Ribi K</searchLink>; International Breast Cancer Study Group (IBCSG), a division of ETOP (European Thoracic Oncology Platform) IBCSG Partners Foundation, Bern, Switzerland; Careum School of Health, Part of the Kalaidos University of Applied Sciences, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ruddy+KJ%22">Ruddy KJ</searchLink>; Department of Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Kammler+R%22">Kammler R</searchLink>; Translational Research Coordination, International Breast Cancer Study Group, a division of ETOP IBCSG Partners Foundation, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22El-Abed+S%22">El-Abed S</searchLink>; Breast International Group (BIG), Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Viale+G%22">Viale G</searchLink>; International Breast Cancer Study Group Central Pathology Office, Bern, Switzerland; Department of Pathology and Laboratory Medicine, IEO, European Institute of Oncology, IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Piccart+M%22">Piccart M</searchLink>; Institut Jules Bordet and Université Libre de Bruxelles, Brussels, Belgium; Breast International Group (BIG), Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Korde+LA%22">Korde LA</searchLink>; Jazz Pharmaceuticals, USA.<br /><searchLink fieldCode="AU" term="%22Goldhirsch+A%22">Goldhirsch A</searchLink>; International Breast Cancer Study Group, Division of ETOP IBCSG Partners Foundation, Bern, Switzerland; IEO, European Institute of Oncology, IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Gelber+RD%22">Gelber RD</searchLink>; International Breast Cancer Study Group Statistical Center, Boston, MA, USA; Department of Data Science, Division of Biostatistics, Dana-Farber Cancer Institute, Boston, MA, USA; Frontier Science and Technology Research Foundation, Boston, MA USA; Harvard TH Chan School of Public Health, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Partridge+AH%22">Partridge AH</searchLink>; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
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