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Comorbid neuropathologies but not Braak stage influence cognitive impairment in primary age-related tauopathy.

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Title: Comorbid neuropathologies but not Braak stage influence cognitive impairment in primary age-related tauopathy.
Authors: Kandoi S; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Department of Artificial Intelligence & Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Hiya S; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Maldonado-Díaz C; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Rohde SK; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Department of Pathology, Amsterdam UMC NL, Amsterdam, The Netherlands., Bernardes C; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga, Portugal.; Department of Neuroradiology, Unidade Local de Saúde de Santo António, Porto, Portugal., Almeida FC; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga, Portugal.; Department of Neuroradiology, Unidade Local de Saúde de Santo António, Porto, Portugal., Samanamud J; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Clare K; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Virata MC; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Slocum CC; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Mir E; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States., White CL 3rd; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, United States., Daoud EV; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, United States., Farrell K; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Department of Artificial Intelligence & Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Crary JF; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Department of Artificial Intelligence & Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Oliveira TG; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga, Portugal.; Department of Neuroradiology, Hospital de Braga, ULS Braga, Sete Fontes-São Victor, Braga, Portugal., Gonzales MM; Department of Neurology, Cedars Sinai Medical Center, Los Angeles, CA, United States., Walker JM; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Richardson TE; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Source: Journal of neuropathology and experimental neurology [J Neuropathol Exp Neurol] 2026 May 29. Date of Electronic Publication: 2026 May 29.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 2985192R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-6578 (Electronic) Linking ISSN: 00223069 NLM ISO Abbreviation: J Neuropathol Exp Neurol Subsets: MEDLINE
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  Data: Comorbid neuropathologies but not Braak stage influence cognitive impairment in primary age-related tauopathy.
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  Data: <searchLink fieldCode="AU" term="%22Kandoi+S%22">Kandoi S</searchLink>; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Department of Artificial Intelligence & Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States.<br /><searchLink fieldCode="AU" term="%22Hiya+S%22">Hiya S</searchLink>; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.<br /><searchLink fieldCode="AU" term="%22Maldonado-Díaz+C%22">Maldonado-Díaz C</searchLink>; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.<br /><searchLink fieldCode="AU" term="%22Rohde+SK%22">Rohde SK</searchLink>; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Department of Pathology, Amsterdam UMC NL, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Bernardes+C%22">Bernardes C</searchLink>; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga, Portugal.; Department of Neuroradiology, Unidade Local de Saúde de Santo António, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Almeida+FC%22">Almeida FC</searchLink>; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga, Portugal.; Department of Neuroradiology, Unidade Local de Saúde de Santo António, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Samanamud+J%22">Samanamud J</searchLink>; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.<br /><searchLink fieldCode="AU" term="%22Clare+K%22">Clare K</searchLink>; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.<br /><searchLink fieldCode="AU" term="%22Virata+MC%22">Virata MC</searchLink>; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.<br /><searchLink fieldCode="AU" term="%22Slocum+CC%22">Slocum CC</searchLink>; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.<br /><searchLink fieldCode="AU" term="%22Mir+E%22">Mir E</searchLink>; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.<br /><searchLink fieldCode="AU" term="%22White+CL+3rd%22">White CL 3rd</searchLink>; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, United States.<br /><searchLink fieldCode="AU" term="%22Daoud+EV%22">Daoud EV</searchLink>; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, United States.<br /><searchLink fieldCode="AU" term="%22Farrell+K%22">Farrell K</searchLink>; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Department of Artificial Intelligence & Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, United States.<br /><searchLink fieldCode="AU" term="%22Crary+JF%22">Crary JF</searchLink>; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Department of Artificial Intelligence & Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, United States.<br /><searchLink fieldCode="AU" term="%22Oliveira+TG%22">Oliveira TG</searchLink>; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga, Portugal.; Department of Neuroradiology, Hospital de Braga, ULS Braga, Sete Fontes-São Victor, Braga, Portugal.<br /><searchLink fieldCode="AU" term="%22Gonzales+MM%22">Gonzales MM</searchLink>; Department of Neurology, Cedars Sinai Medical Center, Los Angeles, CA, United States.<br /><searchLink fieldCode="AU" term="%22Walker+JM%22">Walker JM</searchLink>; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, United States.<br /><searchLink fieldCode="AU" term="%22Richardson+TE%22">Richardson TE</searchLink>; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
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  Data: <searchLink fieldCode="JN" term="%222985192R%22">Journal of neuropathology and experimental neurology</searchLink> [J Neuropathol Exp Neurol] 2026 May 29. <i>Date of Electronic Publication: </i>2026 May 29.
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