R-loop homeostasis at transposable elements safeguards transcriptional silencing in replication-quiescent oocytes.

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Title: R-loop homeostasis at transposable elements safeguards transcriptional silencing in replication-quiescent oocytes.
Authors: Liu SY; The Affiliated Panyu Central Hospital, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China.; Bioscience and Biomedical Engineering Thrust, System Hub, Hong Kong University of Science and Technology (Guangzhou), Guangzhou, China., Tian XY; Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Fu HF; The Affiliated Panyu Central Hospital, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China., Zhou Y; Fertility Preservation Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China., Cai YS; The Affiliated Panyu Central Hospital, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China., Wen J; The Affiliated Panyu Central Hospital, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China., Wang ZL; The Affiliated Panyu Central Hospital, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China., Wu YW; MOE Key Laboratory for Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, China., Lu QW; The Affiliated Panyu Central Hospital, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China.; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, China., Liao XQ; The Affiliated Panyu Central Hospital, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China., Sha QQ; The Affiliated Panyu Central Hospital, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China. shaqianqian@zju.edu.cn.; Fertility Preservation Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China. shaqianqian@zju.edu.cn.
Source: Nature communications [Nat Commun] 2026 May 29. Date of Electronic Publication: 2026 May 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: R-loop homeostasis at transposable elements safeguards transcriptional silencing in replication-quiescent oocytes.
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  Data: <searchLink fieldCode="AU" term="%22Liu+SY%22">Liu SY</searchLink>; The Affiliated Panyu Central Hospital, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China.; Bioscience and Biomedical Engineering Thrust, System Hub, Hong Kong University of Science and Technology (Guangzhou), Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Tian+XY%22">Tian XY</searchLink>; Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Fu+HF%22">Fu HF</searchLink>; The Affiliated Panyu Central Hospital, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Fertility Preservation Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Cai+YS%22">Cai YS</searchLink>; The Affiliated Panyu Central Hospital, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wen+J%22">Wen J</searchLink>; The Affiliated Panyu Central Hospital, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+ZL%22">Wang ZL</searchLink>; The Affiliated Panyu Central Hospital, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wu+YW%22">Wu YW</searchLink>; MOE Key Laboratory for Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Lu+QW%22">Lu QW</searchLink>; The Affiliated Panyu Central Hospital, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China.; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Liao+XQ%22">Liao XQ</searchLink>; The Affiliated Panyu Central Hospital, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Sha+QQ%22">Sha QQ</searchLink>; The Affiliated Panyu Central Hospital, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China. shaqianqian@zju.edu.cn.; Fertility Preservation Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China. shaqianqian@zju.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 May 29. <i>Date of Electronic Publication: </i>2026 May 29.
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        Value: 10.1038/s41467-026-73781-y
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        Text: English
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      – TitleFull: R-loop homeostasis at transposable elements safeguards transcriptional silencing in replication-quiescent oocytes.
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            – D: 29
              M: 05
              Text: 2026 May 29
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