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The benchmarking and application of tag-degraders in vivo to validate therapeutic targets.

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Title: The benchmarking and application of tag-degraders in vivo to validate therapeutic targets.
Authors: Magtoto CM; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia., Mieruszynski S; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia., Dong H; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia., Ng AP; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.; Clinical Haematology Department, The Royal Melbourne Hospital, Peter MacCallum Cancer Centre, Parkville, Victoria, 3050, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, 3010, Australia., Di Rago L; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia., Kueh AJ; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia.; School of Cancer Medicine, La Trobe University, Bundoora, Melbourne, VIC 3086, Australia., Brzozowski M; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia., Grohmann C; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia., Walker JR; Promega Biosciences LLC, 277 Granada Drive, San Luis Obispo, CA, 93401, USA., Chua NK; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia., Dagley LF; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia., Ciulli A; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, Dundee, DD1 5JJ, UK., Lessene G; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.; Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, VIC 3010, Australia., Herold MJ; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia.; School of Cancer Medicine, La Trobe University, Bundoora, Melbourne, VIC 3086, Australia., Heath JK; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia., Silke J; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia., Feltham R; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia. feltham.r@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia. feltham.r@wehi.edu.au.
Source: Nature communications [Nat Commun] 2026 May 29; Vol. 17 (1). Date of Electronic Publication: 2026 May 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Magtoto+CM%22">Magtoto CM</searchLink>; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Mieruszynski+S%22">Mieruszynski S</searchLink>; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Dong+H%22">Dong H</searchLink>; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Ng+AP%22">Ng AP</searchLink>; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.; Clinical Haematology Department, The Royal Melbourne Hospital, Peter MacCallum Cancer Centre, Parkville, Victoria, 3050, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Di+Rago+L%22">Di Rago L</searchLink>; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Kueh+AJ%22">Kueh AJ</searchLink>; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia.; School of Cancer Medicine, La Trobe University, Bundoora, Melbourne, VIC 3086, Australia.<br /><searchLink fieldCode="AU" term="%22Brzozowski+M%22">Brzozowski M</searchLink>; 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Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, Dundee, DD1 5JJ, UK.<br /><searchLink fieldCode="AU" term="%22Lessene+G%22">Lessene G</searchLink>; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.; Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Herold+MJ%22">Herold MJ</searchLink>; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia.; School of Cancer Medicine, La Trobe University, Bundoora, Melbourne, VIC 3086, Australia.<br /><searchLink fieldCode="AU" term="%22Heath+JK%22">Heath JK</searchLink>; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Silke+J%22">Silke J</searchLink>; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Feltham+R%22">Feltham R</searchLink>; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia. feltham.r@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia. feltham.r@wehi.edu.au.
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