The benchmarking and application of tag-degraders in vivo to validate therapeutic targets.
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| Title: | The benchmarking and application of tag-degraders in vivo to validate therapeutic targets. |
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| Authors: | Magtoto CM; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia., Mieruszynski S; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia., Dong H; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia., Ng AP; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.; Clinical Haematology Department, The Royal Melbourne Hospital, Peter MacCallum Cancer Centre, Parkville, Victoria, 3050, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, 3010, Australia., Di Rago L; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia., Kueh AJ; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia.; School of Cancer Medicine, La Trobe University, Bundoora, Melbourne, VIC 3086, Australia., Brzozowski M; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia., Grohmann C; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia., Walker JR; Promega Biosciences LLC, 277 Granada Drive, San Luis Obispo, CA, 93401, USA., Chua NK; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia., Dagley LF; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia., Ciulli A; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, Dundee, DD1 5JJ, UK., Lessene G; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.; Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, VIC 3010, Australia., Herold MJ; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia.; School of Cancer Medicine, La Trobe University, Bundoora, Melbourne, VIC 3086, Australia., Heath JK; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia., Silke J; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia., Feltham R; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia. feltham.r@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia. feltham.r@wehi.edu.au. |
| Source: | Nature communications [Nat Commun] 2026 May 29; Vol. 17 (1). Date of Electronic Publication: 2026 May 29. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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