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DCLK1 mediates airway epithelial barrier disruption through NF-κB activation in severe asthma.

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Title: DCLK1 mediates airway epithelial barrier disruption through NF-κB activation in severe asthma.
Authors: Cheng WH; School of Respiratory Therapy, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan.; Respiratory Therapy, Division of Pulmonary Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.; Chen Wei-Tien Research Center for Thoracic Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Master program in Thoracic Medicine, School of Respiratory Therapy, Taipei Medical University, Taipei, Taiwan., Neoh MM; School of Respiratory Therapy, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan.; Master program in Thoracic Medicine, School of Respiratory Therapy, Taipei Medical University, Taipei, Taiwan., Chen KY; Chen Wei-Tien Research Center for Thoracic Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Division of Pulmonary Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan., Lee KY; Chen Wei-Tien Research Center for Thoracic Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Division of Pulmonary Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan., Feng PH; Chen Wei-Tien Research Center for Thoracic Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Division of Pulmonary Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan., Wu YC; School of Respiratory Therapy, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan.; Chen Wei-Tien Research Center for Thoracic Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Master program in Thoracic Medicine, School of Respiratory Therapy, Taipei Medical University, Taipei, Taiwan., Lin LY; School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Yuliani FS; Department of Pharmacology and Therapy, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia., Wang YA; Department of Integrated Diagnostics & Therapeutics, National Taiwan University Hospital, Taipei, Taiwan., Lin CH; Chen Wei-Tien Research Center for Thoracic Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. chlin@tmu.edu.tw.; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan. chlin@tmu.edu.tw., Chen BC; School of Respiratory Therapy, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan. bcchen@tmu.edu.tw.; Chen Wei-Tien Research Center for Thoracic Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. bcchen@tmu.edu.tw.; Master program in Thoracic Medicine, School of Respiratory Therapy, Taipei Medical University, Taipei, Taiwan. bcchen@tmu.edu.tw.
Source: Molecular medicine (Cambridge, Mass.) [Mol Med] 2026 May 29. Date of Electronic Publication: 2026 May 29.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 9501023 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-3658 (Electronic) Linking ISSN: 10761551 NLM ISO Abbreviation: Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: DCLK1 mediates airway epithelial barrier disruption through NF-κB activation in severe asthma.
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  Data: <searchLink fieldCode="AU" term="%22Cheng+WH%22">Cheng WH</searchLink>; School of Respiratory Therapy, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan.; Respiratory Therapy, Division of Pulmonary Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.; Chen Wei-Tien Research Center for Thoracic Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Master program in Thoracic Medicine, School of Respiratory Therapy, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Neoh+MM%22">Neoh MM</searchLink>; School of Respiratory Therapy, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan.; Master program in Thoracic Medicine, School of Respiratory Therapy, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+KY%22">Chen KY</searchLink>; Chen Wei-Tien Research Center for Thoracic Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Division of Pulmonary Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+KY%22">Lee KY</searchLink>; Chen Wei-Tien Research Center for Thoracic Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Division of Pulmonary Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Feng+PH%22">Feng PH</searchLink>; Chen Wei-Tien Research Center for Thoracic Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Division of Pulmonary Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+YC%22">Wu YC</searchLink>; School of Respiratory Therapy, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan.; Chen Wei-Tien Research Center for Thoracic Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Master program in Thoracic Medicine, School of Respiratory Therapy, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+LY%22">Lin LY</searchLink>; School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yuliani+FS%22">Yuliani FS</searchLink>; Department of Pharmacology and Therapy, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.<br /><searchLink fieldCode="AU" term="%22Wang+YA%22">Wang YA</searchLink>; Department of Integrated Diagnostics & Therapeutics, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+CH%22">Lin CH</searchLink>; Chen Wei-Tien Research Center for Thoracic Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. chlin@tmu.edu.tw.; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan. chlin@tmu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Chen+BC%22">Chen BC</searchLink>; School of Respiratory Therapy, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan. bcchen@tmu.edu.tw.; Chen Wei-Tien Research Center for Thoracic Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. bcchen@tmu.edu.tw.; Master program in Thoracic Medicine, School of Respiratory Therapy, Taipei Medical University, Taipei, Taiwan. bcchen@tmu.edu.tw.
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        Value: 10.1186/s10020-026-01513-5
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        Text: English
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      – TitleFull: DCLK1 mediates airway epithelial barrier disruption through NF-κB activation in severe asthma.
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            – D: 29
              M: 05
              Text: 2026 May 29
              Type: published
              Y: 2026
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