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Cu(ATSM) Restores Blood-Brain Barrier Abundance of P-Glycoprotein and Improves Cognitive Function in the APP/PS1 Mouse Model of Alzheimer's Disease.

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Title: Cu(ATSM) Restores Blood-Brain Barrier Abundance of P-Glycoprotein and Improves Cognitive Function in the APP/PS1 Mouse Model of Alzheimer's Disease.
Authors: Pyun J; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.; Pharmacy and Pharmaceutical Sciences Education, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., Noor A; School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3052, Australia., Runwal P; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., Mawal C; Oxidation Biology Lab, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3052, Australia., Fuller OK; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia., Egan CL; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia., Febbraio MA; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia., Donnelly PS; School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3052, Australia., Short JL; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia., Bush AI; Oxidation Biology Lab, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3052, Australia., Nicolazzo JA; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Source: ACS chemical neuroscience [ACS Chem Neurosci] 2026 Jun 17; Vol. 17 (12), pp. 2389-2405. Date of Electronic Publication: 2026 May 30.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Pyun+J%22">Pyun J</searchLink>; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.; Pharmacy and Pharmaceutical Sciences Education, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Noor+A%22">Noor A</searchLink>; School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Runwal+P%22">Runwal P</searchLink>; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Mawal+C%22">Mawal C</searchLink>; Oxidation Biology Lab, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Fuller+OK%22">Fuller OK</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Egan+CL%22">Egan CL</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Febbraio+MA%22">Febbraio MA</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Donnelly+PS%22">Donnelly PS</searchLink>; School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Short+JL%22">Short JL</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Bush+AI%22">Bush AI</searchLink>; Oxidation Biology Lab, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Nicolazzo+JA%22">Nicolazzo JA</searchLink>; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
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  Data: <searchLink fieldCode="JN" term="%22101525337%22">ACS chemical neuroscience</searchLink> [ACS Chem Neurosci] 2026 Jun 17; Vol. 17 (12), pp. 2389-2405. <i>Date of Electronic Publication: </i>2026 May 30.
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              Text: 2026 Jun 17
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