Novel gastroprotective role of Alogliptin: Modulating the GDNF/PI3K/Akt/GSK3β, SDF-1/CXCR4, and CREB/COX-2/PGE2 signalling pathways to ameliorate diclofenac-induced peptic ulcer in rats.

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Title: Novel gastroprotective role of Alogliptin: Modulating the GDNF/PI3K/Akt/GSK3β, SDF-1/CXCR4, and CREB/COX-2/PGE2 signalling pathways to ameliorate diclofenac-induced peptic ulcer in rats.
Authors: Ghoneim ME; Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Sadat City (USC), Sadat City, 32897, Egypt. Electronic address: mai.ghoneim@fop.usc.edu.eg., Noureldin MH; Department of Biochemistry, Clinical and Biological Sciences Division, College of Pharmacy, Arab Academy for Science, Technology and Maritime Transport, P.O. Box 1029, Alexandria, Egypt. Electronic address: Mohamed.noureldin@aast.edu., El Sayed I; Department of Pharmacy, Faculty of Pharmacy, Nursing and Medical Sciences, Riyadh Elm University, Riyadh, Saudi Arabia. Electronic address: Ibrahim.hassan@riyadh.edu.sa., El Banna YY; Department of Pharmacology and Toxicology, Clinical and Biological Sciences Division, College of Pharmacy, Arab Academy for Science, Technology and Maritime Transport, P.O. Box 1029, Alexandria, Egypt. Electronic address: yousrayelbanna@aast.edu., El Sayed NF; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt. Electronic address: Nermein.fawzy@acu.edu.eg.
Source: European journal of pharmacology [Eur J Pharmacol] 2026 Jul 10; Vol. 1029, pp. 179066. Date of Electronic Publication: 2026 May 30.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1879-0712
DOI:10.1016/j.ejphar.2026.179066