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Multi-ancestry transcriptome-wide association studies uncover insights into breast cancer genetics and biology.

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Title: Multi-ancestry transcriptome-wide association studies uncover insights into breast cancer genetics and biology.
Authors: Ping J; Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Public Health Sciences, University of Miami School of Medicine, Miami, FL, USA., Jia G; Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Cai Q; Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Guo X; Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Wang J; Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Tao R; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Li B; Department of Molecular Physiology & Biophysics, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA., Bauer JA; Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Xie Y; Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA., Ambs S; Laboratory of Human Carcinogenesis, Center of Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Barnard ME; Slone Epidemiology Center, Boston University, Boston, MA, USA., Chen Y; Department of Population Health, Division of Epidemiology, NYU Grossman School of Medicine, New York, NY, USA., Choi JY; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea., Gao YT; State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Garcia-Closas M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Gu J; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hu JJ; Department of Public Health Sciences, University of Miami School of Medicine, Miami, FL, USA., Iwasaki M; Division of Epidemiology, National Cancer Center Institute for Cancer Control, Tokyo, Japan., John EM; Departments of Epidemiology & Population Health and of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Kweon SS; Department of Preventive Medicine, Chonnam National University Medical School, Hwasun, Republic of Korea.; Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, Hwasun, Republic of Korea., Li CI; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Matsuda K; Laboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Matsuo K; Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.; Division of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Nathanson KL; Department of Medicine, Division of Hematology/Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Basser Center for BRCA, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Nemesure B; Department of Family, Population and Preventive Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA., Olopade OI; Department of Medicine, Center for Clinical Cancer Genetics and Global Health, The University of Chicago, Chicago, IL, USA., Pal T; Department of Medicine, Division of Genetic Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Park SK; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.; Integrated Major in Innovative Medical Science, Seoul National University College of Medicine, Seoul, Republic of Korea.; Cancer Research Institute, Seoul National University, Seoul, Republic of Korea., Park B; Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea., Press MF; Department of Pathology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA., Sanderson M; Department of Family and Community Medicine, Meharry Medical College, Nashville, TN, USA., Sandler DP; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Durham, NC, USA., Yao S; Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Zheng Y; Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China., Ahearn T; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Brewster AM; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Falusi A; Genetic and Bioethics Research Unit, Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria., Hennis AJM; Department of Family, Population and Preventive Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.; George Alleyne Chronic Disease Research Centre, University of the West Indies, Bridgetown, Barbados., Ito H; Division of Cancer Information and Control, Aichi Cancer Center Research Institute, Nagoya, Japan.; Department of Descriptive Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Kubo M; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Lee ES; National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea.; Hospital, National Cancer Center, Goyang, Republic of Korea., Makumbi T; Department of Surgery, Mulago Hospital, Kampala, Uganda., Mapoko BSE; Yaounde Central Hospital, Yaounde, Cameroon., Noh DY; College of Medicine, Cancer Research Institute, Seoul National University, Seoul, Republic of Korea.; Department of Surgery, Seoul National University Hospital, Seoul, Republic of Korea., O'Brien KM; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Durham, NC, USA., Ojengbede O; Center for Population and Reproductive Health, College of Medicine, University of Ibadan, Ibadan, Nigeria., Olshan AF; Department of Epidemiology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Park MH; Department of Surgery, Chonnam National University Medical School, Gwangju, Republic of Korea., Reid S; Division of Hematology and Oncology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Yamaji T; Division of Epidemiology, National Cancer Center Institute for Cancer Control, Tokyo, Japan., Zirpoli G; Slone Epidemiology Center, Boston University, Boston, MA, USA., Butler EN; Department of Epidemiology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Huang M; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Low SK; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Obafunwa J; Department of Pathology and Forensic Medicine, Lagos State University Teaching Hospital, Lagos, Nigeria., Weinberg CR; Biostatistics and Computational Biology Branch, National Institutes of Environmental Health Sciences, Research Triangle Park, Durham, NC, USA., Zhang H; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Zhao H; Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA., Ambrosone CB; Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Cote ML; Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA.; Simon Comprehensive Cancer Center, Indianapolis, IN, USA., Huo D; Department of Public Health Sciences, The University of Chicago, Chicago, IL, USA., Haiman CA; Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA., Kang D; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea., Palmer JR; Slone Epidemiology Center, Boston University, Boston, MA, USA., Troester MA; Department of Epidemiology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Shu XO; Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Long J; Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Zheng W; Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA. wei.zheng@vanderbilt.edu.
Source: Nature communications [Nat Commun] 2026 May 30. Date of Electronic Publication: 2026 May 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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          Dates:
            – D: 30
              M: 05
              Text: 2026 May 30
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1