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Dupilumab attenuate IL-4 and IL-13 synergistic effect on airway remodeling in asthma via blocking IL-4Rα/STAT6 axis.

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Title: Dupilumab attenuate IL-4 and IL-13 synergistic effect on airway remodeling in asthma via blocking IL-4Rα/STAT6 axis.
Authors: Sahnoon L; Research Institute of Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.; College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.; Institute for Nutritional Medicine, University of Lübeck, Lübeck, Germany., Abujabal R; Research Institute of Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.; College of Medicine, University of Sharjah, Sharjah, United Arab Emirates., Alanta TM; Research Institute of Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates., Mdkhana B; Research Institute of Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates., Olivenstein R; Meakins-Christie Laboratories, McGill University, Montreal, QC, Canada., Puré E; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA., Mahboub B; Department of Pulmonary Medicine, Rashid Hospital, Dubai, United Arab Emirates. drbassam_mahboub@yahoo.com., Laumonnier Y; Institute for Nutritional Medicine, University of Lübeck, Lübeck, Germany.; Airway Research Center North, Member of the German Center for Lung Research (DZL), Lübeck, Germany., Hamoudi R; Research Institute of Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.; College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.; Biomedically Informed Artificial Intelligence Laboratory (BIMAI-Lab), University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.; Division of Surgery and Interventional Science, University College London, London, WC1E 6BT, UK., Bajbouj K; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA. kbajbouj@upenn.edu., Hamid Q; Research Institute of Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates. qalheialy@sharjah.ac.ae.; College of Medicine, University of Sharjah, Sharjah, United Arab Emirates. qalheialy@sharjah.ac.ae.; Meakins-Christie Laboratories, McGill University, Montreal, QC, Canada. qalheialy@sharjah.ac.ae.
Source: Scientific reports [Sci Rep] 2026 May 30. Date of Electronic Publication: 2026 May 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Sahnoon+L%22">Sahnoon L</searchLink>; Research Institute of Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.; College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.; Institute for Nutritional Medicine, University of Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Abujabal+R%22">Abujabal R</searchLink>; Research Institute of Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.; College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.<br /><searchLink fieldCode="AU" term="%22Alanta+TM%22">Alanta TM</searchLink>; Research Institute of Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.<br /><searchLink fieldCode="AU" term="%22Mdkhana+B%22">Mdkhana B</searchLink>; Research Institute of Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.<br /><searchLink fieldCode="AU" term="%22Olivenstein+R%22">Olivenstein R</searchLink>; Meakins-Christie Laboratories, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Puré+E%22">Puré E</searchLink>; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Mahboub+B%22">Mahboub B</searchLink>; Department of Pulmonary Medicine, Rashid Hospital, Dubai, United Arab Emirates. drbassam_mahboub@yahoo.com.<br /><searchLink fieldCode="AU" term="%22Laumonnier+Y%22">Laumonnier Y</searchLink>; Institute for Nutritional Medicine, University of Lübeck, Lübeck, Germany.; Airway Research Center North, Member of the German Center for Lung Research (DZL), Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Hamoudi+R%22">Hamoudi R</searchLink>; Research Institute of Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.; College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.; Biomedically Informed Artificial Intelligence Laboratory (BIMAI-Lab), University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.; Division of Surgery and Interventional Science, University College London, London, WC1E 6BT, UK.<br /><searchLink fieldCode="AU" term="%22Bajbouj+K%22">Bajbouj K</searchLink>; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA. kbajbouj@upenn.edu.<br /><searchLink fieldCode="AU" term="%22Hamid+Q%22">Hamid Q</searchLink>; Research Institute of Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates. qalheialy@sharjah.ac.ae.; College of Medicine, University of Sharjah, Sharjah, United Arab Emirates. qalheialy@sharjah.ac.ae.; Meakins-Christie Laboratories, McGill University, Montreal, QC, Canada. qalheialy@sharjah.ac.ae.
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              Text: 2026 May 30
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