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Machine learning-based discovery of GW3965 as a therapeutic compound against invasive emm92-type group A Streptococcus.

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Title: Machine learning-based discovery of GW3965 as a therapeutic compound against invasive emm92-type group A Streptococcus.
Authors: Powell LM; Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, Morgantown, WV, USA., Grund ME; Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, Morgantown, WV, USA., Shi W; Department of Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA., Choi SJ; Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, Morgantown, WV, USA., Zelaya K; Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, Morgantown, WV, USA., Bobbala S; Department of Pharmaceutical Sciences, West Virginia University School of Pharmacy, Morgantown, WV, USA., Geldenhuys W; Department of Pharmaceutical Sciences, West Virginia University School of Pharmacy, Morgantown, WV, USA., Barbier M; Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, Morgantown, WV, USA.; Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, WV, USA., LaSala PR; Department of Pathology, West Virginia University School of Medicine, Morgantown, WV, USA.; Department of Pathology and Laboratory Medicine, University of Connecticut Health, Farmington, CT, USA., Lukomski S; Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, Morgantown, WV, USA. slukomski@hsc.wvu.edu.; West Virginia Clinical and Translational Science Institute, West Virginia University, Morgantown, WV, USA. slukomski@hsc.wvu.edu.
Source: Npj antimicrobials and resistance [NPJ Antimicrob Resist] 2026 May 30. Date of Electronic Publication: 2026 May 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Portfolio Country of Publication: England NLM ID: 9918804282606676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2731-8745 (Electronic) Linking ISSN: 27318745 NLM ISO Abbreviation: NPJ Antimicrob Resist
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  Data: Machine learning-based discovery of GW3965 as a therapeutic compound against invasive emm92-type group A Streptococcus.
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  Data: <searchLink fieldCode="AU" term="%22Powell+LM%22">Powell LM</searchLink>; Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, Morgantown, WV, USA.<br /><searchLink fieldCode="AU" term="%22Grund+ME%22">Grund ME</searchLink>; Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, Morgantown, WV, USA.<br /><searchLink fieldCode="AU" term="%22Shi+W%22">Shi W</searchLink>; Department of Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Choi+SJ%22">Choi SJ</searchLink>; Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, Morgantown, WV, USA.<br /><searchLink fieldCode="AU" term="%22Zelaya+K%22">Zelaya K</searchLink>; Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, Morgantown, WV, USA.<br /><searchLink fieldCode="AU" term="%22Bobbala+S%22">Bobbala S</searchLink>; Department of Pharmaceutical Sciences, West Virginia University School of Pharmacy, Morgantown, WV, USA.<br /><searchLink fieldCode="AU" term="%22Geldenhuys+W%22">Geldenhuys W</searchLink>; Department of Pharmaceutical Sciences, West Virginia University School of Pharmacy, Morgantown, WV, USA.<br /><searchLink fieldCode="AU" term="%22Barbier+M%22">Barbier M</searchLink>; Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, Morgantown, WV, USA.; Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, WV, USA.<br /><searchLink fieldCode="AU" term="%22LaSala+PR%22">LaSala PR</searchLink>; Department of Pathology, West Virginia University School of Medicine, Morgantown, WV, USA.; Department of Pathology and Laboratory Medicine, University of Connecticut Health, Farmington, CT, USA.<br /><searchLink fieldCode="AU" term="%22Lukomski+S%22">Lukomski S</searchLink>; Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, Morgantown, WV, USA. slukomski@hsc.wvu.edu.; West Virginia Clinical and Translational Science Institute, West Virginia University, Morgantown, WV, USA. slukomski@hsc.wvu.edu.
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  Data: <searchLink fieldCode="JN" term="%229918804282606676%22">Npj antimicrobials and resistance</searchLink> [NPJ Antimicrob Resist] 2026 May 30. <i>Date of Electronic Publication: </i>2026 May 30.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Portfolio%22">Nature Portfolio </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9918804282606676 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2731-8745 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2227318745%22">27318745 </searchLink><i>NLM ISO Abbreviation: </i>NPJ Antimicrob Resist
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        Value: 10.1038/s44259-026-00225-4
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              Text: 2026 May 30
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