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Cyclin E1 overexpression identifies a therapeutically relevant poor prognostic patient subgroup in high-grade serous ovarian cancer.

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Title: Cyclin E1 overexpression identifies a therapeutically relevant poor prognostic patient subgroup in high-grade serous ovarian cancer.
Authors: Kim D; Zentalis Pharmaceuticals Inc., San Diego, CA, USA., Chung H; Zentalis Pharmaceuticals Inc., San Diego, CA, USA., Abed M; Zentalis Pharmaceuticals Inc., San Diego, CA, USA., Ma J; Zentalis Pharmaceuticals Inc., San Diego, CA, USA., Molden N; Zentalis Pharmaceuticals Inc., San Diego, CA, USA., Shim C; Zentalis Pharmaceuticals Inc., San Diego, CA, USA., Rajendran D; Zentalis Pharmaceuticals Inc., San Diego, CA, USA., Yen J; Zentalis Pharmaceuticals Inc., San Diego, CA, USA., Jeong J; Zentalis Pharmaceuticals Inc., San Diego, CA, USA., Levy A; Zentalis Pharmaceuticals Inc., San Diego, CA, USA., Yaniz-Galende E; Institut Gustave Roussy, Villejuif, France., Blanc-Durand F; Institut Gustave Roussy, Villejuif, France.; GINECO Group for Early Phase Studies (GINEGEPS), Paris, France., Desauw C; Groupe d'Investigateurs Nationaux pour l'Etude des Cancers de l'Ovaire et du Sein (GINECO), Paris, France.; Centre Hospitalier Régional Universitaire de Lille - Hôpital Hurie, Lille, France., Follana P; Groupe d'Investigateurs Nationaux pour l'Etude des Cancers de l'Ovaire et du Sein (GINECO), Paris, France.; Centre Antoine Lacassagne, Nice, France., Bonichon-Lamichhane N; Groupe d'Investigateurs Nationaux pour l'Etude des Cancers de l'Ovaire et du Sein (GINECO), Paris, France.; Clinique Tivoli, Bordeaux, France., Oudard S; Groupe d'Investigateurs Nationaux pour l'Etude des Cancers de l'Ovaire et du Sein (GINECO), Paris, France.; European Georges Pompidou Hospital, Paris, France., D'Hondt V; Groupe d'Investigateurs Nationaux pour l'Etude des Cancers de l'Ovaire et du Sein (GINECO), Paris, France.; Institut du Cancer de Montpellier, Montpellier, France., Gavoille C; Groupe d'Investigateurs Nationaux pour l'Etude des Cancers de l'Ovaire et du Sein (GINECO), Paris, France.; Centre Alexis Vautrin, Vandœuvre-lès-Nancy, France., Jandial DD; Zentalis Pharmaceuticals Inc., San Diego, CA, USA., Meric-Bernstam F; Department of Investigational Cancer Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Liu JF; Dana Farber Cancer Institute, Boston, MA, USA., Simpkins F; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Penn Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, PA, USA., Randall LM; Gynecologic Oncology Clinical Research and Gynecologic Cancer Service Line, Inova Schar Cancer Institute, Inova Health System, Fairfax, VA, USA., Leary A; Institut Gustave Roussy, Villejuif, France.; GINECO Group for Early Phase Studies (GINEGEPS), Paris, France.; Groupe d'Investigateurs Nationaux pour l'Etude des Cancers de l'Ovaire et du Sein (GINECO), Paris, France., Lackner MR; Zentalis Pharmaceuticals Inc., San Diego, CA, USA., Harismendy O; Zentalis Pharmaceuticals Inc., San Diego, CA, USA. oharismendy@zentalis.com.
Source: NPJ precision oncology [NPJ Precis Oncol] 2026 May 30; Vol. 10 (1). Date of Electronic Publication: 2026 May 30.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101708166 Publication Model: Electronic Cited Medium: Print ISSN: 2397-768X (Print) Linking ISSN: 2397768X NLM ISO Abbreviation: NPJ Precis Oncol Subsets: PubMed not MEDLINE
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  Data: Cyclin E1 overexpression identifies a therapeutically relevant poor prognostic patient subgroup in high-grade serous ovarian cancer.
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  Data: <searchLink fieldCode="AU" term="%22Kim+D%22">Kim D</searchLink>; Zentalis Pharmaceuticals Inc., San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chung+H%22">Chung H</searchLink>; Zentalis Pharmaceuticals Inc., San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Abed+M%22">Abed M</searchLink>; Zentalis Pharmaceuticals Inc., San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; Zentalis Pharmaceuticals Inc., San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Molden+N%22">Molden N</searchLink>; Zentalis Pharmaceuticals Inc., San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shim+C%22">Shim C</searchLink>; Zentalis Pharmaceuticals Inc., San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rajendran+D%22">Rajendran D</searchLink>; Zentalis Pharmaceuticals Inc., San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yen+J%22">Yen J</searchLink>; Zentalis Pharmaceuticals Inc., San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jeong+J%22">Jeong J</searchLink>; Zentalis Pharmaceuticals Inc., San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Levy+A%22">Levy A</searchLink>; Zentalis Pharmaceuticals Inc., San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yaniz-Galende+E%22">Yaniz-Galende E</searchLink>; Institut Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Blanc-Durand+F%22">Blanc-Durand F</searchLink>; Institut Gustave Roussy, Villejuif, France.; GINECO Group for Early Phase Studies (GINEGEPS), Paris, France.<br /><searchLink fieldCode="AU" term="%22Desauw+C%22">Desauw C</searchLink>; Groupe d'Investigateurs Nationaux pour l'Etude des Cancers de l'Ovaire et du Sein (GINECO), Paris, France.; Centre Hospitalier Régional Universitaire de Lille - Hôpital Hurie, Lille, France.<br /><searchLink fieldCode="AU" term="%22Follana+P%22">Follana P</searchLink>; Groupe d'Investigateurs Nationaux pour l'Etude des Cancers de l'Ovaire et du Sein (GINECO), Paris, France.; Centre Antoine Lacassagne, Nice, France.<br /><searchLink fieldCode="AU" term="%22Bonichon-Lamichhane+N%22">Bonichon-Lamichhane N</searchLink>; Groupe d'Investigateurs Nationaux pour l'Etude des Cancers de l'Ovaire et du Sein (GINECO), Paris, France.; Clinique Tivoli, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Oudard+S%22">Oudard S</searchLink>; Groupe d'Investigateurs Nationaux pour l'Etude des Cancers de l'Ovaire et du Sein (GINECO), Paris, France.; European Georges Pompidou Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22D'Hondt+V%22">D'Hondt V</searchLink>; Groupe d'Investigateurs Nationaux pour l'Etude des Cancers de l'Ovaire et du Sein (GINECO), Paris, France.; Institut du Cancer de Montpellier, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Gavoille+C%22">Gavoille C</searchLink>; Groupe d'Investigateurs Nationaux pour l'Etude des Cancers de l'Ovaire et du Sein (GINECO), Paris, France.; Centre Alexis Vautrin, Vandœuvre-lès-Nancy, France.<br /><searchLink fieldCode="AU" term="%22Jandial+DD%22">Jandial DD</searchLink>; Zentalis Pharmaceuticals Inc., San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Meric-Bernstam+F%22">Meric-Bernstam F</searchLink>; Department of Investigational Cancer Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Liu+JF%22">Liu JF</searchLink>; Dana Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Simpkins+F%22">Simpkins F</searchLink>; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Penn Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Randall+LM%22">Randall LM</searchLink>; Gynecologic Oncology Clinical Research and Gynecologic Cancer Service Line, Inova Schar Cancer Institute, Inova Health System, Fairfax, VA, USA.<br /><searchLink fieldCode="AU" term="%22Leary+A%22">Leary A</searchLink>; Institut Gustave Roussy, Villejuif, France.; GINECO Group for Early Phase Studies (GINEGEPS), Paris, France.; Groupe d'Investigateurs Nationaux pour l'Etude des Cancers de l'Ovaire et du Sein (GINECO), Paris, France.<br /><searchLink fieldCode="AU" term="%22Lackner+MR%22">Lackner MR</searchLink>; Zentalis Pharmaceuticals Inc., San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Harismendy+O%22">Harismendy O</searchLink>; Zentalis Pharmaceuticals Inc., San Diego, CA, USA. oharismendy@zentalis.com.
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  Data: <searchLink fieldCode="JN" term="%22101708166%22">NPJ precision oncology</searchLink> [NPJ Precis Oncol] 2026 May 30; Vol. 10 (1). <i>Date of Electronic Publication: </i>2026 May 30.
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