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Ion chromatography-ultra-high-resolution mass spectrometry reveals EZH2-driven reprogramming of nucleic acid and protein methylation.

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Title: Ion chromatography-ultra-high-resolution mass spectrometry reveals EZH2-driven reprogramming of nucleic acid and protein methylation.
Authors: Kaddah MMY; Center for Environmental and Systems Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, KY, 40536, USA; Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA; Pharmaceutical and Fermentation Industries Development Center, City of Scientific Research and Technological Applications, New Borg El-Arab, Alexandria, 21934, Egypt., Fan TW; Center for Environmental and Systems Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, KY, 40536, USA; Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA. Electronic address: Teresa.fan@uky.edu., Islam JMM; Center for Environmental and Systems Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, KY, 40536, USA., Lin P; Center for Environmental and Systems Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, KY, 40536, USA., Cassel TA; Center for Environmental and Systems Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, KY, 40536, USA., Cunningham R; Assemblon Ltd., Atlas Building, Harwell Campus, Didcot, OX11 0QX, England. Electronic address: richard.cunningham@assemblon.co.uk., Brown T; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom., Higashi RM; Center for Environmental and Systems Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, KY, 40536, USA; Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA., Lane AN; Center for Environmental and Systems Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, KY, 40536, USA; Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA. Electronic address: Andrew.lane@uky.edu.
Source: Analytica chimica acta [Anal Chim Acta] 2026 Aug 22; Vol. 1412, pp. 345653. Date of Electronic Publication: 2026 May 13.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0370534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4324 (Electronic) Linking ISSN: 00032670 NLM ISO Abbreviation: Anal Chim Acta Subsets: MEDLINE
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  Data: Ion chromatography-ultra-high-resolution mass spectrometry reveals EZH2-driven reprogramming of nucleic acid and protein methylation.
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  Data: <searchLink fieldCode="AU" term="%22Kaddah+MMY%22">Kaddah MMY</searchLink>; Center for Environmental and Systems Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, KY, 40536, USA; Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA; Pharmaceutical and Fermentation Industries Development Center, City of Scientific Research and Technological Applications, New Borg El-Arab, Alexandria, 21934, Egypt.<br /><searchLink fieldCode="AU" term="%22Fan+TW%22">Fan TW</searchLink>; Center for Environmental and Systems Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, KY, 40536, USA; Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA. Electronic address: Teresa.fan@uky.edu.<br /><searchLink fieldCode="AU" term="%22Islam+JMM%22">Islam JMM</searchLink>; Center for Environmental and Systems Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, KY, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Lin+P%22">Lin P</searchLink>; Center for Environmental and Systems Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, KY, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Cassel+TA%22">Cassel TA</searchLink>; Center for Environmental and Systems Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, KY, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Cunningham+R%22">Cunningham R</searchLink>; Assemblon Ltd., Atlas Building, Harwell Campus, Didcot, OX11 0QX, England. Electronic address: richard.cunningham@assemblon.co.uk.<br /><searchLink fieldCode="AU" term="%22Brown+T%22">Brown T</searchLink>; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Higashi+RM%22">Higashi RM</searchLink>; Center for Environmental and Systems Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, KY, 40536, USA; Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Lane+AN%22">Lane AN</searchLink>; Center for Environmental and Systems Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, KY, 40536, USA; Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA. Electronic address: Andrew.lane@uky.edu.
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  Data: <searchLink fieldCode="JN" term="%220370534%22">Analytica chimica acta</searchLink> [Anal Chim Acta] 2026 Aug 22; Vol. 1412, pp. 345653. <i>Date of Electronic Publication: </i>2026 May 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>0370534 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-4324 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200032670%22">00032670 </searchLink><i>NLM ISO Abbreviation: </i>Anal Chim Acta <i>Subsets: </i>MEDLINE
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              Text: 2026 Aug 22
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