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Apigenin Upregulates Regulatory B Cells, Suppresses Class Switch Recombination, and Restores Immune Homeostasis to Treat Autoimmune Arthritis and Sepsis.

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Title: Apigenin Upregulates Regulatory B Cells, Suppresses Class Switch Recombination, and Restores Immune Homeostasis to Treat Autoimmune Arthritis and Sepsis.
Authors: Chen H; Dongguan Key Laboratory of Chronic Inflammatory Diseases, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan, Guangdong, 523710, People's Republic of China., Huang Y; School of Nursing, Guangdong Pharmaceutical University, Guangzhou, Guangdong, 510310, People's Republic of China.; Liwan District Maternal and Child Health Hospital, Guangzhou, Guangdong, 510000, People's Republic of China., He Y; Dongguan Key Laboratory of Chronic Inflammatory Diseases, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan, Guangdong, 523710, People's Republic of China.; Dongguan Key Laboratory of Sepsis Translational Medicine, The First Dongguan Affiliated Hospital, The Second School of Clinical Medicine, Guangdong Medical University, Dongguan, Guangdong, 523710, People's Republic of China.; The Intensive Care Unit, The First Dongguan Affiliated Hospital, The Second School of Clinical Medicine, Guangdong Medical University, Dongguan, Guangdong, 523710, People's Republic of China., Zha M; Dongguan Key Laboratory of Chronic Inflammatory Diseases, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan, Guangdong, 523710, People's Republic of China., Liu X; Dongguan Key Laboratory of Chronic Inflammatory Diseases, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan, Guangdong, 523710, People's Republic of China., Lin T; School of Nursing, Guangdong Pharmaceutical University, Guangzhou, Guangdong, 510310, People's Republic of China.; The Third Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, 510378, People's Republic of China., Li L; Dongguan Key Laboratory of Chronic Inflammatory Diseases, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan, Guangdong, 523710, People's Republic of China., He Z; Dongguan Central Blood Station, Dongguan, Guangdong, 523930, People's Republic of China., Zheng SG; Dongguan Key Laboratory of Chronic Inflammatory Diseases, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan, Guangdong, 523710, People's Republic of China.; Department of Immunology, School of Cell and Gene Therapy, Songjiang Institute and Songjiang Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, People's Republic of China.; State Key Laboratory of Innovative Immunotherapy, Shanghai Jiao Tong University, Shanghai, 201600, People's Republic of China., Shao Y; Dongguan Key Laboratory of Sepsis Translational Medicine, The First Dongguan Affiliated Hospital, The Second School of Clinical Medicine, Guangdong Medical University, Dongguan, Guangdong, 523710, People's Republic of China.; The Intensive Care Unit, The First Dongguan Affiliated Hospital, The Second School of Clinical Medicine, Guangdong Medical University, Dongguan, Guangdong, 523710, People's Republic of China., Luo A; School of Nursing, Guangdong Pharmaceutical University, Guangzhou, Guangdong, 510310, People's Republic of China., Sun J; Dongguan Key Laboratory of Chronic Inflammatory Diseases, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan, Guangdong, 523710, People's Republic of China.
Source: Drug design, development and therapy [Drug Des Devel Ther] 2026 May 25; Vol. 20, pp. 603143. Date of Electronic Publication: 2026 May 25 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE
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  Data: Apigenin Upregulates Regulatory B Cells, Suppresses Class Switch Recombination, and Restores Immune Homeostasis to Treat Autoimmune Arthritis and Sepsis.
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  Data: <searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Dongguan Key Laboratory of Chronic Inflammatory Diseases, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan, Guangdong, 523710, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; School of Nursing, Guangdong Pharmaceutical University, Guangzhou, Guangdong, 510310, People's Republic of China.; Liwan District Maternal and Child Health Hospital, Guangzhou, Guangdong, 510000, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22He+Y%22">He Y</searchLink>; Dongguan Key Laboratory of Chronic Inflammatory Diseases, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan, Guangdong, 523710, People's Republic of China.; Dongguan Key Laboratory of Sepsis Translational Medicine, The First Dongguan Affiliated Hospital, The Second School of Clinical Medicine, Guangdong Medical University, Dongguan, Guangdong, 523710, People's Republic of China.; The Intensive Care Unit, The First Dongguan Affiliated Hospital, The Second School of Clinical Medicine, Guangdong Medical University, Dongguan, Guangdong, 523710, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zha+M%22">Zha M</searchLink>; Dongguan Key Laboratory of Chronic Inflammatory Diseases, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan, Guangdong, 523710, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Dongguan Key Laboratory of Chronic Inflammatory Diseases, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan, Guangdong, 523710, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Lin+T%22">Lin T</searchLink>; School of Nursing, Guangdong Pharmaceutical University, Guangzhou, Guangdong, 510310, People's Republic of China.; The Third Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, 510378, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Dongguan Key Laboratory of Chronic Inflammatory Diseases, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan, Guangdong, 523710, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22He+Z%22">He Z</searchLink>; Dongguan Central Blood Station, Dongguan, Guangdong, 523930, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zheng+SG%22">Zheng SG</searchLink>; Dongguan Key Laboratory of Chronic Inflammatory Diseases, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan, Guangdong, 523710, People's Republic of China.; Department of Immunology, School of Cell and Gene Therapy, Songjiang Institute and Songjiang Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, People's Republic of China.; State Key Laboratory of Innovative Immunotherapy, Shanghai Jiao Tong University, Shanghai, 201600, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Shao+Y%22">Shao Y</searchLink>; Dongguan Key Laboratory of Sepsis Translational Medicine, The First Dongguan Affiliated Hospital, The Second School of Clinical Medicine, Guangdong Medical University, Dongguan, Guangdong, 523710, People's Republic of China.; The Intensive Care Unit, The First Dongguan Affiliated Hospital, The Second School of Clinical Medicine, Guangdong Medical University, Dongguan, Guangdong, 523710, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Luo+A%22">Luo A</searchLink>; School of Nursing, Guangdong Pharmaceutical University, Guangzhou, Guangdong, 510310, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Sun+J%22">Sun J</searchLink>; Dongguan Key Laboratory of Chronic Inflammatory Diseases, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan, Guangdong, 523710, People's Republic of China.
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        Value: 10.2147/DDDT.S603143
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        Text: English
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      – TitleFull: Apigenin Upregulates Regulatory B Cells, Suppresses Class Switch Recombination, and Restores Immune Homeostasis to Treat Autoimmune Arthritis and Sepsis.
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