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Preclinical evaluation of rBCG-h12: an engineered Bacillus Calmette-Guérin with an enhanced activity against bladder and pancreatic cancers.

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Title: Preclinical evaluation of rBCG-h12: an engineered Bacillus Calmette-Guérin with an enhanced activity against bladder and pancreatic cancers.
Authors: Yeh CC; National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan., Fan CS; National Institute of Cancer Research, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan., Chen LL; National Institute of Cancer Research, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan., Chua KV; National Institute of Cancer Research, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan., Hsu CH; National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan., Chen CC; National Institute of Cancer Research, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan., Tan ZL; National Institute of Cancer Research, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan., Tsai PC; National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan., Song YD; National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan., Low YS; National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan., Yang SJ; National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan., Chen YY; Department of Biochemical Science and Technology, National Chiayi University, Chiayi City, 600, Taiwan., Lin YX; National Institute of Cancer Research, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan., Wu CM; National Institute of Cancer Research, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan., Dou HY; National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan. hydou@nhri.edu.tw., Huang TS; National Institute of Cancer Research, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan. tshuang@nhri.org.tw.; Department of Biochemistry, School of Medicine, Kaohsiung Medical University, Kaohsiung City, 807, Taiwan. tshuang@nhri.org.tw.; Doctoral Program in Tissue Engineering and Regenerative Medicine, Biotechnology Center, National Chung Hsing University, Taichung City, 402, Taiwan. tshuang@nhri.org.tw.
Source: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2026 Jun 01. Date of Electronic Publication: 2026 Jun 01.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8605732 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0851 (Electronic) Linking ISSN: 03407004 NLM ISO Abbreviation: Cancer Immunol Immunother Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Preclinical evaluation of rBCG-h12: an engineered Bacillus Calmette-Guérin with an enhanced activity against bladder and pancreatic cancers.
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  Data: <searchLink fieldCode="AU" term="%22Yeh+CC%22">Yeh CC</searchLink>; National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan.<br /><searchLink fieldCode="AU" term="%22Fan+CS%22">Fan CS</searchLink>; National Institute of Cancer Research, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+LL%22">Chen LL</searchLink>; National Institute of Cancer Research, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chua+KV%22">Chua KV</searchLink>; National Institute of Cancer Research, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsu+CH%22">Hsu CH</searchLink>; National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CC%22">Chen CC</searchLink>; National Institute of Cancer Research, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tan+ZL%22">Tan ZL</searchLink>; National Institute of Cancer Research, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+PC%22">Tsai PC</searchLink>; National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan.<br /><searchLink fieldCode="AU" term="%22Song+YD%22">Song YD</searchLink>; National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan.<br /><searchLink fieldCode="AU" term="%22Low+YS%22">Low YS</searchLink>; National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+SJ%22">Yang SJ</searchLink>; National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YY%22">Chen YY</searchLink>; Department of Biochemical Science and Technology, National Chiayi University, Chiayi City, 600, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+YX%22">Lin YX</searchLink>; National Institute of Cancer Research, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+CM%22">Wu CM</searchLink>; National Institute of Cancer Research, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan.<br /><searchLink fieldCode="AU" term="%22Dou+HY%22">Dou HY</searchLink>; National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan. hydou@nhri.edu.tw.<br /><searchLink fieldCode="AU" term="%22Huang+TS%22">Huang TS</searchLink>; National Institute of Cancer Research, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan. tshuang@nhri.org.tw.; Department of Biochemistry, School of Medicine, Kaohsiung Medical University, Kaohsiung City, 807, Taiwan. tshuang@nhri.org.tw.; Doctoral Program in Tissue Engineering and Regenerative Medicine, Biotechnology Center, National Chung Hsing University, Taichung City, 402, Taiwan. tshuang@nhri.org.tw.
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  Data: <searchLink fieldCode="JN" term="%228605732%22">Cancer immunology, immunotherapy : CII</searchLink> [Cancer Immunol Immunother] 2026 Jun 01. <i>Date of Electronic Publication: </i>2026 Jun 01.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>8605732 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0851 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203407004%22">03407004 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Immunol Immunother <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1007/s00262-026-04441-9
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      – Code: eng
        Text: English
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      – TitleFull: Preclinical evaluation of rBCG-h12: an engineered Bacillus Calmette-Guérin with an enhanced activity against bladder and pancreatic cancers.
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              Text: 2026 Jun 01
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              Y: 2026
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