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Mutational signatures of environmental carcinogens in human tissue organoids revealed by duplex sequencing.

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Title: Mutational signatures of environmental carcinogens in human tissue organoids revealed by duplex sequencing.
Authors: Kucab JE; Department of Analytical, Environmental and Forensic Sciences, School of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London SE1 9NH, UK. Electronic address: jill.kucab@kcl.ac.uk., Nandi SP; Department of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA, USA., Al-Serori H; Department of Analytical, Environmental and Forensic Sciences, School of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London SE1 9NH, UK., Dunstone E; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK., Beck RSS; Department of Analytical, Environmental and Forensic Sciences, School of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London SE1 9NH, UK., Caipa Garcia AL; Department of Analytical, Environmental and Forensic Sciences, School of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London SE1 9NH, UK., Wilde EC; Department of Analytical, Environmental and Forensic Sciences, School of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London SE1 9NH, UK., Saeed S; Department of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA, USA., Francies H; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK., Garnett MJ; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK., Fu B; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK., Yang F; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK., Saeb-Parsy K; Department of Surgery, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Huch M; Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany., Drost J; Princess Máxima Center for Pediatric Oncology, Oncode Institute, Utrecht 3584 CS, the Netherlands., Zilbauer M; Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK., Humphreys L; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK., Kisby G; Department of Biomedical Sciences, Western University of Health Sciences, Lebanon, OR 97355, USA., Arlt VM; Department of Analytical, Environmental and Forensic Sciences, School of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London SE1 9NH, UK., Stratton MR; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK., Alexandrov LB; Department of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA, USA., Phillips DH; Department of Analytical, Environmental and Forensic Sciences, School of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London SE1 9NH, UK. Electronic address: david.phillips@kcl.ac.uk.
Source: Cell reports [Cell Rep] 2026 Jun 23; Vol. 45 (6), pp. 117406. Date of Electronic Publication: 2026 Jun 01.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
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  Data: Mutational signatures of environmental carcinogens in human tissue organoids revealed by duplex sequencing.
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  Data: <searchLink fieldCode="AU" term="%22Kucab+JE%22">Kucab JE</searchLink>; Department of Analytical, Environmental and Forensic Sciences, School of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London SE1 9NH, UK. Electronic address: jill.kucab@kcl.ac.uk.<br /><searchLink fieldCode="AU" term="%22Nandi+SP%22">Nandi SP</searchLink>; Department of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Al-Serori+H%22">Al-Serori H</searchLink>; Department of Analytical, Environmental and Forensic Sciences, School of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London SE1 9NH, UK.<br /><searchLink fieldCode="AU" term="%22Dunstone+E%22">Dunstone E</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Beck+RSS%22">Beck RSS</searchLink>; Department of Analytical, Environmental and Forensic Sciences, School of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London SE1 9NH, UK.<br /><searchLink fieldCode="AU" term="%22Caipa+Garcia+AL%22">Caipa Garcia AL</searchLink>; Department of Analytical, Environmental and Forensic Sciences, School of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London SE1 9NH, UK.<br /><searchLink fieldCode="AU" term="%22Wilde+EC%22">Wilde EC</searchLink>; Department of Analytical, Environmental and Forensic Sciences, School of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London SE1 9NH, UK.<br /><searchLink fieldCode="AU" term="%22Saeed+S%22">Saeed S</searchLink>; Department of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Francies+H%22">Francies H</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Garnett+MJ%22">Garnett MJ</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Fu+B%22">Fu B</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Yang+F%22">Yang F</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Saeb-Parsy+K%22">Saeb-Parsy K</searchLink>; Department of Surgery, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Huch+M%22">Huch M</searchLink>; Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Drost+J%22">Drost J</searchLink>; Princess Máxima Center for Pediatric Oncology, Oncode Institute, Utrecht 3584 CS, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Zilbauer+M%22">Zilbauer M</searchLink>; Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Humphreys+L%22">Humphreys L</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Kisby+G%22">Kisby G</searchLink>; Department of Biomedical Sciences, Western University of Health Sciences, Lebanon, OR 97355, USA.<br /><searchLink fieldCode="AU" term="%22Arlt+VM%22">Arlt VM</searchLink>; Department of Analytical, Environmental and Forensic Sciences, School of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London SE1 9NH, UK.<br /><searchLink fieldCode="AU" term="%22Stratton+MR%22">Stratton MR</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Alexandrov+LB%22">Alexandrov LB</searchLink>; Department of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Phillips+DH%22">Phillips DH</searchLink>; Department of Analytical, Environmental and Forensic Sciences, School of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London SE1 9NH, UK. Electronic address: david.phillips@kcl.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2026 Jun 23; Vol. 45 (6), pp. 117406. <i>Date of Electronic Publication: </i>2026 Jun 01.
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