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AAV8-mediated mouse/human PROC expression rescues thrombophilia in hereditary protein C-deficient mice.

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Title: AAV8-mediated mouse/human PROC expression rescues thrombophilia in hereditary protein C-deficient mice.
Authors: Wu T; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Key Laboratory of Biological Targeted Therapies of the Chinese Ministry of Education, Wuhan, China., Tao Y; Department of Hematology, West China Hospital, Sichuan University, Chengdu, China., Lu H; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Key Laboratory of Biological Targeted Therapies of the Chinese Ministry of Education, Wuhan, China., Cai Y; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Key Laboratory of Biological Targeted Therapies of the Chinese Ministry of Education, Wuhan, China., Xia Y; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Key Laboratory of Biological Targeted Therapies of the Chinese Ministry of Education, Wuhan, China., Liu T; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Key Laboratory of Biological Targeted Therapies of the Chinese Ministry of Education, Wuhan, China., Wang L; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Key Laboratory of Biological Targeted Therapies of the Chinese Ministry of Education, Wuhan, China., Cheng Z; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Key Laboratory of Biological Targeted Therapies of the Chinese Ministry of Education, Wuhan, China., Hu Y; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Key Laboratory of Biological Targeted Therapies of the Chinese Ministry of Education, Wuhan, China., Corral J; Department of Hematology, Hospital Universitario Morales Meseguer, University of Murcia, Instituto Murciano de Investigacion Biosanitaria (IMIB)-Pascual Parrilla, Centro de Investigacion Biomedica en Red de Enfermedades Raras (CIBERER)-Instituto de Salud Carlos III, Murcia, Spain. javier.corral@carm.es., Tang LV; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. lancet.tang@qq.com.; Key Laboratory of Biological Targeted Therapies of the Chinese Ministry of Education, Wuhan, China. lancet.tang@qq.com.
Source: Gene therapy [Gene Ther] 2026 Jun 01. Date of Electronic Publication: 2026 Jun 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9421525 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5462 (Electronic) Linking ISSN: 09697128 NLM ISO Abbreviation: Gene Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: AAV8-mediated mouse/human PROC expression rescues thrombophilia in hereditary protein C-deficient mice.
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  Data: <searchLink fieldCode="AU" term="%22Wu+T%22">Wu T</searchLink>; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Key Laboratory of Biological Targeted Therapies of the Chinese Ministry of Education, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Tao+Y%22">Tao Y</searchLink>; Department of Hematology, West China Hospital, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Lu+H%22">Lu H</searchLink>; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Key Laboratory of Biological Targeted Therapies of the Chinese Ministry of Education, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Cai+Y%22">Cai Y</searchLink>; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Key Laboratory of Biological Targeted Therapies of the Chinese Ministry of Education, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Xia+Y%22">Xia Y</searchLink>; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Key Laboratory of Biological Targeted Therapies of the Chinese Ministry of Education, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Liu+T%22">Liu T</searchLink>; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Key Laboratory of Biological Targeted Therapies of the Chinese Ministry of Education, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Key Laboratory of Biological Targeted Therapies of the Chinese Ministry of Education, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Cheng+Z%22">Cheng Z</searchLink>; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Key Laboratory of Biological Targeted Therapies of the Chinese Ministry of Education, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Hu+Y%22">Hu Y</searchLink>; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Key Laboratory of Biological Targeted Therapies of the Chinese Ministry of Education, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Corral+J%22">Corral J</searchLink>; Department of Hematology, Hospital Universitario Morales Meseguer, University of Murcia, Instituto Murciano de Investigacion Biosanitaria (IMIB)-Pascual Parrilla, Centro de Investigacion Biomedica en Red de Enfermedades Raras (CIBERER)-Instituto de Salud Carlos III, Murcia, Spain. javier.corral@carm.es.<br /><searchLink fieldCode="AU" term="%22Tang+LV%22">Tang LV</searchLink>; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. lancet.tang@qq.com.; Key Laboratory of Biological Targeted Therapies of the Chinese Ministry of Education, Wuhan, China. lancet.tang@qq.com.
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            – D: 01
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              Text: 2026 Jun 01
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