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Preventing MALT1-mediated CYLD cleavage induces intestinal dysbiosis and reduces EAE severity.

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Title: Preventing MALT1-mediated CYLD cleavage induces intestinal dysbiosis and reduces EAE severity.
Authors: Skordos I; Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium., Gilis E; Molecular Immunology and Inflammation Unit, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Rheumatology, Department of Internal Medicine and Pediatrics, Ghent, Belgium., Callewaert C; Ghent University, Center for Microbial Ecology and Technology, Ghent, Belgium., Aidarova A; Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium., Haegman M; Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium., Driege Y; Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium., Kreike M; Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium., Afonina IS; Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium., Staal J; Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium., Demeyer A; Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium.; Ghent University, Department of Head and Skin, Ghent, Belgium., Elewaut D; Molecular Immunology and Inflammation Unit, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Rheumatology, Department of Internal Medicine and Pediatrics, Ghent, Belgium., Beyaert R; Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, VIB, Ghent, Belgium. rudi@irc.vib-ugent.be.; Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium. rudi@irc.vib-ugent.be.
Source: EMBO reports [EMBO Rep] 2026 Jul; Vol. 27 (13), pp. 3731-3758. Date of Electronic Publication: 2026 Jun 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Preventing MALT1-mediated CYLD cleavage induces intestinal dysbiosis and reduces EAE severity.
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  Data: <searchLink fieldCode="AU" term="%22Skordos+I%22">Skordos I</searchLink>; Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Gilis+E%22">Gilis E</searchLink>; Molecular Immunology and Inflammation Unit, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Rheumatology, Department of Internal Medicine and Pediatrics, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Callewaert+C%22">Callewaert C</searchLink>; Ghent University, Center for Microbial Ecology and Technology, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Aidarova+A%22">Aidarova A</searchLink>; Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Haegman+M%22">Haegman M</searchLink>; Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Driege+Y%22">Driege Y</searchLink>; Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Kreike+M%22">Kreike M</searchLink>; Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Afonina+IS%22">Afonina IS</searchLink>; Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Staal+J%22">Staal J</searchLink>; Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Demeyer+A%22">Demeyer A</searchLink>; Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium.; Ghent University, Department of Head and Skin, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Elewaut+D%22">Elewaut D</searchLink>; Molecular Immunology and Inflammation Unit, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Rheumatology, Department of Internal Medicine and Pediatrics, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Beyaert+R%22">Beyaert R</searchLink>; Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, VIB, Ghent, Belgium. rudi@irc.vib-ugent.be.; Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium. rudi@irc.vib-ugent.be.
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  Data: <searchLink fieldCode="JN" term="%22100963049%22">EMBO reports</searchLink> [EMBO Rep] 2026 Jul; Vol. 27 (13), pp. 3731-3758. <i>Date of Electronic Publication: </i>2026 Jun 01.
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