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IFI16 restricts SARS-CoV-2 replication by disrupting nucleocapsid-driven phase separation.

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Title: IFI16 restricts SARS-CoV-2 replication by disrupting nucleocapsid-driven phase separation.
Authors: Cislaghi I; Virology Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy., Turati S; Virology Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy., Vicario D; Virology Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy., Griffante G; Virology Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.; Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy., Chandel S; Virology Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy., Cigno IL; Virology Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy., Bizzarri R; Department of Surgical, Medical, Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.; Center for Instrument Sharing of the University of Pisa (CISUP), University of Pisa, Pisa, Italy.; Istituto Nanoscienze, CNR, NEST-SNS, Pisa, Italy., Storti B; Istituto Nanoscienze, CNR, NEST-SNS, Pisa, Italy., Godec TU; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Zachrdla M; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Zweckstetter M; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.; Department for NMR-based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany., Signorini L; Laboratory of Molecular Virology, Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milano, Italy., Maina KK; Laboratory of Molecular Virology, Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milano, Italy., Delbue S; Laboratory of Molecular Virology, Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milano, Italy., Borgogna C; Virology Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy. cinzia.borgogna@med.uniupo.it., Gariglio M; Virology Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy. marisa.gariglio@med.uniupo.it.
Source: Communications biology [Commun Biol] 2026 Jun 01. Date of Electronic Publication: 2026 Jun 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
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  Data: IFI16 restricts SARS-CoV-2 replication by disrupting nucleocapsid-driven phase separation.
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  Data: <searchLink fieldCode="AU" term="%22Cislaghi+I%22">Cislaghi I</searchLink>; Virology Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.<br /><searchLink fieldCode="AU" term="%22Turati+S%22">Turati S</searchLink>; Virology Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.<br /><searchLink fieldCode="AU" term="%22Vicario+D%22">Vicario D</searchLink>; Virology Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.<br /><searchLink fieldCode="AU" term="%22Griffante+G%22">Griffante G</searchLink>; Virology Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.; Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Chandel+S%22">Chandel S</searchLink>; Virology Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.<br /><searchLink fieldCode="AU" term="%22Cigno+IL%22">Cigno IL</searchLink>; Virology Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.<br /><searchLink fieldCode="AU" term="%22Bizzarri+R%22">Bizzarri R</searchLink>; Department of Surgical, Medical, Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.; Center for Instrument Sharing of the University of Pisa (CISUP), University of Pisa, Pisa, Italy.; Istituto Nanoscienze, CNR, NEST-SNS, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Storti+B%22">Storti B</searchLink>; Istituto Nanoscienze, CNR, NEST-SNS, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Godec+TU%22">Godec TU</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Zachrdla+M%22">Zachrdla M</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Zweckstetter+M%22">Zweckstetter M</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.; Department for NMR-based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Signorini+L%22">Signorini L</searchLink>; Laboratory of Molecular Virology, Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Maina+KK%22">Maina KK</searchLink>; Laboratory of Molecular Virology, Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Delbue+S%22">Delbue S</searchLink>; Laboratory of Molecular Virology, Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Borgogna+C%22">Borgogna C</searchLink>; Virology Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy. cinzia.borgogna@med.uniupo.it.<br /><searchLink fieldCode="AU" term="%22Gariglio+M%22">Gariglio M</searchLink>; Virology Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy. marisa.gariglio@med.uniupo.it.
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