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Regulatory factor X 7 limits Myc activity during B cell activation and suppresses Myc-dependent lymphomagenesis.

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Title: Regulatory factor X 7 limits Myc activity during B cell activation and suppresses Myc-dependent lymphomagenesis.
Authors: Fischer BA; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Khameneh HJ; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Guerra J; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Zenobi A; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Ciorciari J; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Buzzago I; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Merli MS; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Said M; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Ventura PMO; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Pfister A; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Mattei L; Cantonal Institute of Pathology Ente Ospedaliero Cantonale (EOC), Locarno, Switzerland., Cavalli D; Cantonal Institute of Pathology Ente Ospedaliero Cantonale (EOC), Locarno, Switzerland., Molinari F; Cantonal Institute of Pathology Ente Ospedaliero Cantonale (EOC), Locarno, Switzerland., Rinaldi A; Institute of Oncology Research, Università della Svizzera italiana, Bellinzona, Switzerland., Moro SG; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Kwee I; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.; BigOmics Analytics SA, Lugano, Switzerland., Morone D; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Mosole S; Institute of Oncology Research, Università della Svizzera italiana, Bellinzona, Switzerland., Jarrossay D; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Montanino C; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Simonelli L; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Varani L; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Radice E; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Thelen M; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Di Serio C; University Centre of Statistics in the Biomedical Sciences (CUSSB), Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.; Biomedical Faculty, Università della Svizzera Italiana, Lugano, Switzerland.; Clinical Trial Unit (CTU), EOC, Locarno, Switzerland., Calabretta E; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Shipp MA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Dreval K; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada., Morin R; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada.; Centre for Lymphoid Cancer, BC Cancer, Vancouver, British Columbia, Canada.; Canada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada., Scott DW; Centre for Lymphoid Cancer, BC Cancer, Vancouver, British Columbia, Canada., Jauk F; Cantonal Institute of Pathology Ente Ospedaliero Cantonale (EOC), Locarno, Switzerland.; Institute of Oncology Research, Università della Svizzera italiana, Bellinzona, Switzerland., Frattini M; Cantonal Institute of Pathology Ente Ospedaliero Cantonale (EOC), Locarno, Switzerland., Barizzi J; Cantonal Institute of Pathology Ente Ospedaliero Cantonale (EOC), Locarno, Switzerland., Cascione L; Institute of Oncology Research, Università della Svizzera italiana, Bellinzona, Switzerland., Bertoni F; Institute of Oncology Research, Università della Svizzera italiana, Bellinzona, Switzerland., Robbiani DF; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Rossi D; Institute of Oncology Research, Università della Svizzera italiana, Bellinzona, Switzerland.; Division of Hematology, Oncology Institute of Southern Switzerland, EOC, Bellinzona, Switzerland., Guarda G; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland. greta.guarda@irb.usi.ch.
Source: Nature immunology [Nat Immunol] 2026 Jul; Vol. 27 (7), pp. 1490-1501. Date of Electronic Publication: 2026 Jun 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Regulatory factor X 7 limits Myc activity during B cell activation and suppresses Myc-dependent lymphomagenesis.
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  Data: <searchLink fieldCode="AU" term="%22Fischer+BA%22">Fischer BA</searchLink>; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Khameneh+HJ%22">Khameneh HJ</searchLink>; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Guerra+J%22">Guerra J</searchLink>; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Zenobi+A%22">Zenobi A</searchLink>; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ciorciari+J%22">Ciorciari J</searchLink>; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Buzzago+I%22">Buzzago I</searchLink>; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Merli+MS%22">Merli MS</searchLink>; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Said+M%22">Said M</searchLink>; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ventura+PMO%22">Ventura PMO</searchLink>; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Pfister+A%22">Pfister A</searchLink>; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mattei+L%22">Mattei L</searchLink>; Cantonal Institute of Pathology Ente Ospedaliero Cantonale (EOC), Locarno, Switzerland.<br /><searchLink fieldCode="AU" term="%22Cavalli+D%22">Cavalli D</searchLink>; Cantonal Institute of Pathology Ente Ospedaliero Cantonale (EOC), Locarno, Switzerland.<br /><searchLink fieldCode="AU" term="%22Molinari+F%22">Molinari F</searchLink>; Cantonal Institute of Pathology Ente Ospedaliero Cantonale (EOC), Locarno, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rinaldi+A%22">Rinaldi A</searchLink>; Institute of Oncology Research, Università della Svizzera italiana, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Moro+SG%22">Moro SG</searchLink>; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kwee+I%22">Kwee I</searchLink>; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.; BigOmics Analytics SA, Lugano, Switzerland.<br /><searchLink fieldCode="AU" term="%22Morone+D%22">Morone D</searchLink>; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mosole+S%22">Mosole S</searchLink>; Institute of Oncology Research, Università della Svizzera italiana, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Jarrossay+D%22">Jarrossay D</searchLink>; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Montanino+C%22">Montanino C</searchLink>; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Simonelli+L%22">Simonelli L</searchLink>; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Varani+L%22">Varani L</searchLink>; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Radice+E%22">Radice E</searchLink>; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Thelen+M%22">Thelen M</searchLink>; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Di+Serio+C%22">Di Serio C</searchLink>; University Centre of Statistics in the Biomedical Sciences (CUSSB), Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.; Biomedical Faculty, Università della Svizzera Italiana, Lugano, Switzerland.; Clinical Trial Unit (CTU), EOC, Locarno, Switzerland.<br /><searchLink fieldCode="AU" term="%22Calabretta+E%22">Calabretta E</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Shipp+MA%22">Shipp MA</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Dreval+K%22">Dreval K</searchLink>; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Morin+R%22">Morin R</searchLink>; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada.; Centre for Lymphoid Cancer, BC Cancer, Vancouver, British Columbia, Canada.; Canada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Scott+DW%22">Scott DW</searchLink>; Centre for Lymphoid Cancer, BC Cancer, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Jauk+F%22">Jauk F</searchLink>; Cantonal Institute of Pathology Ente Ospedaliero Cantonale (EOC), Locarno, Switzerland.; Institute of Oncology Research, Università della Svizzera italiana, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Frattini+M%22">Frattini M</searchLink>; Cantonal Institute of Pathology Ente Ospedaliero Cantonale (EOC), Locarno, Switzerland.<br /><searchLink fieldCode="AU" term="%22Barizzi+J%22">Barizzi J</searchLink>; Cantonal Institute of Pathology Ente Ospedaliero Cantonale (EOC), Locarno, Switzerland.<br /><searchLink fieldCode="AU" term="%22Cascione+L%22">Cascione L</searchLink>; Institute of Oncology Research, Università della Svizzera italiana, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bertoni+F%22">Bertoni F</searchLink>; Institute of Oncology Research, Università della Svizzera italiana, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Robbiani+DF%22">Robbiani DF</searchLink>; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rossi+D%22">Rossi D</searchLink>; Institute of Oncology Research, Università della Svizzera italiana, Bellinzona, Switzerland.; Division of Hematology, Oncology Institute of Southern Switzerland, EOC, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Guarda+G%22">Guarda G</searchLink>; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland. greta.guarda@irb.usi.ch.
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