View in EDS

Structure-Guided Optimization of Novel Inhibitors of Plasmodium Lysyl-tRNA Synthetase with Multistage Activity against Malaria Parasites.

Saved in:
Bibliographic Details
Title: Structure-Guided Optimization of Novel Inhibitors of Plasmodium Lysyl-tRNA Synthetase with Multistage Activity against Malaria Parasites.
Authors: Forte B; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Bellany F; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Campbell PS; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Chemi G; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Dawson A; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Anderson M; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Aniweh Y; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), College of Basic and Applied Sciences, University of Ghana, Accra LG54, Ghana., Burkhard AY; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States., Aguiar ACC; Department of Microbiology, Immunology, and Parasitology, Federal University of São Paulo, São Paulo, São Paulo CEP 04023-062, Brazil., Churchyard A; Department of Life Sciences, Imperial College, London SW7 2AZ, U.K., Cooper CA; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia 30602-0002, United States., Dos Santos Ferreira A; Oswaldo Cruz Foundation, Leishmaniasis and Malaria Bioassay Platform, Porto Velho, Rondônia CEP 76812-245, Brazil., Famodimu MT; Department of Life Sciences, Imperial College, London SW7 2AZ, U.K.; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K., Fang FG; Eisai, Inc., 35 Cambridge Park Drive Suite 200, Cambridge, Massachusetts 02140, United States., Hu X; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Huijs T; TropIQ Health Sciences, Nijmegen 6534 AT, The Netherlands., Baud D; MMV Medicines for Malaria Venture, ICC, Geneva 1215, Switzerland., Jansen C; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Jiménez Díaz MB; The Art of Discovery, Derio 48160, Spain., Bonnert R; MMV Medicines for Malaria Venture, ICC, Geneva 1215, Switzerland., Boyd S; MMV Medicines for Malaria Venture, ICC, Geneva 1215, Switzerland., Crespo-Fernández B; Global Health Medicines R&D, GSK, Tres Cantos, Madrid 28760, Spain., Mitasev B; Eisai, Inc., 35 Cambridge Park Drive Suite 200, Cambridge, Massachusetts 02140, United States., Montagna S; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Mok S; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States., Murugesan D; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Narwal SK; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States., Norcross NR; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Okombo J; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States., Park H; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States., Peet C; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Pereira DB; Research Center in Tropical Medicine of Rondônia, Porto Velho, Rondônia CEP 76812-329, Brazil., Post JM; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Reader J; Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control University of Pretoria, Hatfield, Pretoria 0028, South Africa., Riley J; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Robinson DA; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Shinkyo R; Eisai, Inc., 35 Cambridge Park Drive Suite 200, Cambridge, Massachusetts 02140, United States., Simeons FRC; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Simpson L; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Smith A; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Smith D; MMV Medicines for Malaria Venture, ICC, Geneva 1215, Switzerland., Striepen J; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States., Teles CBG; Oswaldo Cruz Foundation, Leishmaniasis and Malaria Bioassay Platform, Porto Velho, Rondônia CEP 76812-245, Brazil., van der Laak R; TropIQ Health Sciences, Nijmegen 6534 AT, The Netherlands., Uhlemann AC; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States., Vantaux A; Malaria Molecular Epidemiology Unit, Institut Pasteur du Cambodge, Phnom Penh 120210, Cambodia., Wilson C; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Witkowski B; São Carlos Institute of Physics, University of São Paulo, São Carlos, São Paulo CEP 13563-120, Brazil., Wood G; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Yeo T; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States., Zuccotto F; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Angulo-Barturen I; The Art of Discovery, Derio 48160, Spain., Baum J; Department of Life Sciences, Imperial College, London SW7 2AZ, U.K., Bolscher JM; TropIQ Health Sciences, Nijmegen 6534 AT, The Netherlands., Guido RVC; São Carlos Institute of Physics, University of São Paulo, São Carlos, São Paulo CEP 13563-120, Brazil., Birkholtz LM; Department of Biochemistry, Stellenbosch University, Stellenbosch, Matieland 7602, South Africa., Delves MJ; Department of Life Sciences, Imperial College, London SW7 2AZ, U.K.; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K., Dembele L; Univerité Des Sciences, Des Techniques Et Des Technologies de Bamako (USTTB), Parasite and Microbe Research and Training Centre (P-MRTC), Faculty of Pharmacy, Point G, Bamako BP 1805, Mali., Fidock DA; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States., Gamo FJ; Global Health Medicines R&D, GSK, Tres Cantos, Madrid 28760, Spain., Kyle DE; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia 30602-0002, United States., Maher SP; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia 30602-0002, United States., Popovici J; Malaria Research Unit, Institut Pasteur du Cambodge, Phnom Penh 120210, Cambodia.; Infectious Disease Epidemiology and Analytics G5 Unit, Institut Pasteur, Université Paris Cité, Paris 75015, France., Walpole C; Structural Genomics Consortium, Research Institute of the McGill University Health Centre, Montreal, Québec H4A 3J1, Canada., Gusovsky F; Eisai, Inc., 35 Cambridge Park Drive Suite 200, Cambridge, Massachusetts 02140, United States., Willis PA; MMV Medicines for Malaria Venture, ICC, Geneva 1215, Switzerland., Read KD; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Gilbert IH; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Baragaña B; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Source: Journal of medicinal chemistry [J Med Chem] 2026 Jun 11; Vol. 69 (11), pp. 13820-13855. Date of Electronic Publication: 2026 Jun 02.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42227818
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Structure-Guided Optimization of Novel Inhibitors of Plasmodium Lysyl-tRNA Synthetase with Multistage Activity against Malaria Parasites.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Forte+B%22">Forte B</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Bellany+F%22">Bellany F</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Campbell+PS%22">Campbell PS</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Chemi+G%22">Chemi G</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Dawson+A%22">Dawson A</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Anderson+M%22">Anderson M</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Aniweh+Y%22">Aniweh Y</searchLink>; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), College of Basic and Applied Sciences, University of Ghana, Accra LG54, Ghana.<br /><searchLink fieldCode="AU" term="%22Burkhard+AY%22">Burkhard AY</searchLink>; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States.<br /><searchLink fieldCode="AU" term="%22Aguiar+ACC%22">Aguiar ACC</searchLink>; Department of Microbiology, Immunology, and Parasitology, Federal University of São Paulo, São Paulo, São Paulo CEP 04023-062, Brazil.<br /><searchLink fieldCode="AU" term="%22Churchyard+A%22">Churchyard A</searchLink>; Department of Life Sciences, Imperial College, London SW7 2AZ, U.K.<br /><searchLink fieldCode="AU" term="%22Cooper+CA%22">Cooper CA</searchLink>; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia 30602-0002, United States.<br /><searchLink fieldCode="AU" term="%22Dos+Santos+Ferreira+A%22">Dos Santos Ferreira A</searchLink>; Oswaldo Cruz Foundation, Leishmaniasis and Malaria Bioassay Platform, Porto Velho, Rondônia CEP 76812-245, Brazil.<br /><searchLink fieldCode="AU" term="%22Famodimu+MT%22">Famodimu MT</searchLink>; Department of Life Sciences, Imperial College, London SW7 2AZ, U.K.; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K.<br /><searchLink fieldCode="AU" term="%22Fang+FG%22">Fang FG</searchLink>; Eisai, Inc., 35 Cambridge Park Drive Suite 200, Cambridge, Massachusetts 02140, United States.<br /><searchLink fieldCode="AU" term="%22Hu+X%22">Hu X</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Huijs+T%22">Huijs T</searchLink>; TropIQ Health Sciences, Nijmegen 6534 AT, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Baud+D%22">Baud D</searchLink>; MMV Medicines for Malaria Venture, ICC, Geneva 1215, Switzerland.<br /><searchLink fieldCode="AU" term="%22Jansen+C%22">Jansen C</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Jiménez+Díaz+MB%22">Jiménez Díaz MB</searchLink>; The Art of Discovery, Derio 48160, Spain.<br /><searchLink fieldCode="AU" term="%22Bonnert+R%22">Bonnert R</searchLink>; MMV Medicines for Malaria Venture, ICC, Geneva 1215, Switzerland.<br /><searchLink fieldCode="AU" term="%22Boyd+S%22">Boyd S</searchLink>; MMV Medicines for Malaria Venture, ICC, Geneva 1215, Switzerland.<br /><searchLink fieldCode="AU" term="%22Crespo-Fernández+B%22">Crespo-Fernández B</searchLink>; Global Health Medicines R&D, GSK, Tres Cantos, Madrid 28760, Spain.<br /><searchLink fieldCode="AU" term="%22Mitasev+B%22">Mitasev B</searchLink>; Eisai, Inc., 35 Cambridge Park Drive Suite 200, Cambridge, Massachusetts 02140, United States.<br /><searchLink fieldCode="AU" term="%22Montagna+S%22">Montagna S</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Mok+S%22">Mok S</searchLink>; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States.<br /><searchLink fieldCode="AU" term="%22Murugesan+D%22">Murugesan D</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Narwal+SK%22">Narwal SK</searchLink>; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States.<br /><searchLink fieldCode="AU" term="%22Norcross+NR%22">Norcross NR</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Okombo+J%22">Okombo J</searchLink>; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States.<br /><searchLink fieldCode="AU" term="%22Park+H%22">Park H</searchLink>; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States.<br /><searchLink fieldCode="AU" term="%22Peet+C%22">Peet C</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Pereira+DB%22">Pereira DB</searchLink>; Research Center in Tropical Medicine of Rondônia, Porto Velho, Rondônia CEP 76812-329, Brazil.<br /><searchLink fieldCode="AU" term="%22Post+JM%22">Post JM</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Reader+J%22">Reader J</searchLink>; Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control University of Pretoria, Hatfield, Pretoria 0028, South Africa.<br /><searchLink fieldCode="AU" term="%22Riley+J%22">Riley J</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Robinson+DA%22">Robinson DA</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Shinkyo+R%22">Shinkyo R</searchLink>; Eisai, Inc., 35 Cambridge Park Drive Suite 200, Cambridge, Massachusetts 02140, United States.<br /><searchLink fieldCode="AU" term="%22Simeons+FRC%22">Simeons FRC</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Simpson+L%22">Simpson L</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Smith+A%22">Smith A</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Smith+D%22">Smith D</searchLink>; MMV Medicines for Malaria Venture, ICC, Geneva 1215, Switzerland.<br /><searchLink fieldCode="AU" term="%22Striepen+J%22">Striepen J</searchLink>; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States.<br /><searchLink fieldCode="AU" term="%22Teles+CBG%22">Teles CBG</searchLink>; Oswaldo Cruz Foundation, Leishmaniasis and Malaria Bioassay Platform, Porto Velho, Rondônia CEP 76812-245, Brazil.<br /><searchLink fieldCode="AU" term="%22van+der+Laak+R%22">van der Laak R</searchLink>; TropIQ Health Sciences, Nijmegen 6534 AT, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Uhlemann+AC%22">Uhlemann AC</searchLink>; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States.<br /><searchLink fieldCode="AU" term="%22Vantaux+A%22">Vantaux A</searchLink>; Malaria Molecular Epidemiology Unit, Institut Pasteur du Cambodge, Phnom Penh 120210, Cambodia.<br /><searchLink fieldCode="AU" term="%22Wilson+C%22">Wilson C</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Witkowski+B%22">Witkowski B</searchLink>; São Carlos Institute of Physics, University of São Paulo, São Carlos, São Paulo CEP 13563-120, Brazil.<br /><searchLink fieldCode="AU" term="%22Wood+G%22">Wood G</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Yeo+T%22">Yeo T</searchLink>; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States.<br /><searchLink fieldCode="AU" term="%22Zuccotto+F%22">Zuccotto F</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Angulo-Barturen+I%22">Angulo-Barturen I</searchLink>; The Art of Discovery, Derio 48160, Spain.<br /><searchLink fieldCode="AU" term="%22Baum+J%22">Baum J</searchLink>; Department of Life Sciences, Imperial College, London SW7 2AZ, U.K.<br /><searchLink fieldCode="AU" term="%22Bolscher+JM%22">Bolscher JM</searchLink>; TropIQ Health Sciences, Nijmegen 6534 AT, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Guido+RVC%22">Guido RVC</searchLink>; São Carlos Institute of Physics, University of São Paulo, São Carlos, São Paulo CEP 13563-120, Brazil.<br /><searchLink fieldCode="AU" term="%22Birkholtz+LM%22">Birkholtz LM</searchLink>; Department of Biochemistry, Stellenbosch University, Stellenbosch, Matieland 7602, South Africa.<br /><searchLink fieldCode="AU" term="%22Delves+MJ%22">Delves MJ</searchLink>; Department of Life Sciences, Imperial College, London SW7 2AZ, U.K.; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K.<br /><searchLink fieldCode="AU" term="%22Dembele+L%22">Dembele L</searchLink>; Univerité Des Sciences, Des Techniques Et Des Technologies de Bamako (USTTB), Parasite and Microbe Research and Training Centre (P-MRTC), Faculty of Pharmacy, Point G, Bamako BP 1805, Mali.<br /><searchLink fieldCode="AU" term="%22Fidock+DA%22">Fidock DA</searchLink>; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States.<br /><searchLink fieldCode="AU" term="%22Gamo+FJ%22">Gamo FJ</searchLink>; Global Health Medicines R&D, GSK, Tres Cantos, Madrid 28760, Spain.<br /><searchLink fieldCode="AU" term="%22Kyle+DE%22">Kyle DE</searchLink>; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia 30602-0002, United States.<br /><searchLink fieldCode="AU" term="%22Maher+SP%22">Maher SP</searchLink>; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia 30602-0002, United States.<br /><searchLink fieldCode="AU" term="%22Popovici+J%22">Popovici J</searchLink>; Malaria Research Unit, Institut Pasteur du Cambodge, Phnom Penh 120210, Cambodia.; Infectious Disease Epidemiology and Analytics G5 Unit, Institut Pasteur, Université Paris Cité, Paris 75015, France.<br /><searchLink fieldCode="AU" term="%22Walpole+C%22">Walpole C</searchLink>; Structural Genomics Consortium, Research Institute of the McGill University Health Centre, Montreal, Québec H4A 3J1, Canada.<br /><searchLink fieldCode="AU" term="%22Gusovsky+F%22">Gusovsky F</searchLink>; Eisai, Inc., 35 Cambridge Park Drive Suite 200, Cambridge, Massachusetts 02140, United States.<br /><searchLink fieldCode="AU" term="%22Willis+PA%22">Willis PA</searchLink>; MMV Medicines for Malaria Venture, ICC, Geneva 1215, Switzerland.<br /><searchLink fieldCode="AU" term="%22Read+KD%22">Read KD</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Gilbert+IH%22">Gilbert IH</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Baragaña+B%22">Baragaña B</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2026 Jun 11; Vol. 69 (11), pp. 13820-13855. <i>Date of Electronic Publication: </i>2026 Jun 02.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42227818
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1021/acs.jmedchem.6c00823
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 13820
    Titles:
      – TitleFull: Structure-Guided Optimization of Novel Inhibitors of Plasmodium Lysyl-tRNA Synthetase with Multistage Activity against Malaria Parasites.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Forte B
      – PersonEntity:
          Name:
            NameFull: Bellany F
      – PersonEntity:
          Name:
            NameFull: Campbell PS
      – PersonEntity:
          Name:
            NameFull: Chemi G
      – PersonEntity:
          Name:
            NameFull: Dawson A
      – PersonEntity:
          Name:
            NameFull: Anderson M
      – PersonEntity:
          Name:
            NameFull: Aniweh Y
      – PersonEntity:
          Name:
            NameFull: Burkhard AY
      – PersonEntity:
          Name:
            NameFull: Aguiar ACC
      – PersonEntity:
          Name:
            NameFull: Churchyard A
      – PersonEntity:
          Name:
            NameFull: Cooper CA
      – PersonEntity:
          Name:
            NameFull: Dos Santos Ferreira A
      – PersonEntity:
          Name:
            NameFull: Famodimu MT
      – PersonEntity:
          Name:
            NameFull: Fang FG
      – PersonEntity:
          Name:
            NameFull: Hu X
      – PersonEntity:
          Name:
            NameFull: Huijs T
      – PersonEntity:
          Name:
            NameFull: Baud D
      – PersonEntity:
          Name:
            NameFull: Jansen C
      – PersonEntity:
          Name:
            NameFull: Jiménez Díaz MB
      – PersonEntity:
          Name:
            NameFull: Bonnert R
      – PersonEntity:
          Name:
            NameFull: Boyd S
      – PersonEntity:
          Name:
            NameFull: Crespo-Fernández B
      – PersonEntity:
          Name:
            NameFull: Mitasev B
      – PersonEntity:
          Name:
            NameFull: Montagna S
      – PersonEntity:
          Name:
            NameFull: Mok S
      – PersonEntity:
          Name:
            NameFull: Murugesan D
      – PersonEntity:
          Name:
            NameFull: Narwal SK
      – PersonEntity:
          Name:
            NameFull: Norcross NR
      – PersonEntity:
          Name:
            NameFull: Okombo J
      – PersonEntity:
          Name:
            NameFull: Park H
      – PersonEntity:
          Name:
            NameFull: Peet C
      – PersonEntity:
          Name:
            NameFull: Pereira DB
      – PersonEntity:
          Name:
            NameFull: Post JM
      – PersonEntity:
          Name:
            NameFull: Reader J
      – PersonEntity:
          Name:
            NameFull: Riley J
      – PersonEntity:
          Name:
            NameFull: Robinson DA
      – PersonEntity:
          Name:
            NameFull: Shinkyo R
      – PersonEntity:
          Name:
            NameFull: Simeons FRC
      – PersonEntity:
          Name:
            NameFull: Simpson L
      – PersonEntity:
          Name:
            NameFull: Smith A
      – PersonEntity:
          Name:
            NameFull: Smith D
      – PersonEntity:
          Name:
            NameFull: Striepen J
      – PersonEntity:
          Name:
            NameFull: Teles CBG
      – PersonEntity:
          Name:
            NameFull: van der Laak R
      – PersonEntity:
          Name:
            NameFull: Uhlemann AC
      – PersonEntity:
          Name:
            NameFull: Vantaux A
      – PersonEntity:
          Name:
            NameFull: Wilson C
      – PersonEntity:
          Name:
            NameFull: Witkowski B
      – PersonEntity:
          Name:
            NameFull: Wood G
      – PersonEntity:
          Name:
            NameFull: Yeo T
      – PersonEntity:
          Name:
            NameFull: Zuccotto F
      – PersonEntity:
          Name:
            NameFull: Angulo-Barturen I
      – PersonEntity:
          Name:
            NameFull: Baum J
      – PersonEntity:
          Name:
            NameFull: Bolscher JM
      – PersonEntity:
          Name:
            NameFull: Guido RVC
      – PersonEntity:
          Name:
            NameFull: Birkholtz LM
      – PersonEntity:
          Name:
            NameFull: Delves MJ
      – PersonEntity:
          Name:
            NameFull: Dembele L
      – PersonEntity:
          Name:
            NameFull: Fidock DA
      – PersonEntity:
          Name:
            NameFull: Gamo FJ
      – PersonEntity:
          Name:
            NameFull: Kyle DE
      – PersonEntity:
          Name:
            NameFull: Maher SP
      – PersonEntity:
          Name:
            NameFull: Popovici J
      – PersonEntity:
          Name:
            NameFull: Walpole C
      – PersonEntity:
          Name:
            NameFull: Gusovsky F
      – PersonEntity:
          Name:
            NameFull: Willis PA
      – PersonEntity:
          Name:
            NameFull: Read KD
      – PersonEntity:
          Name:
            NameFull: Gilbert IH
      – PersonEntity:
          Name:
            NameFull: Baragaña B
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 11
              M: 06
              Text: 2026 Jun 11
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1520-4804
          Numbering:
            – Type: volume
              Value: 69
            – Type: issue
              Value: 11
          Titles:
            – TitleFull: Journal of medicinal chemistry
              Type: main
ResultId 1