Personalized automatic management of tracheal cuff pressure and subglottic secretions drainage to prevent pneumonia in critically ill intubated patients. The MICROINHALO multicenter randomized controlled trial.
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| Title: | Personalized automatic management of tracheal cuff pressure and subglottic secretions drainage to prevent pneumonia in critically ill intubated patients. The MICROINHALO multicenter randomized controlled trial. |
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| Authors: | De Pascale G; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy. gennaro.depascalemd@gmail.com.; Department of Emergency Sciences, Anaesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. gennaro.depascalemd@gmail.com., Cutuli SL; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Emergency Sciences, Anaesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Vargas M; Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy., Cortegiani A; General Intensive Care Unit, University Hospital Policlinico Paolo Giaccone, Palermo, Italy.; Department of Precision Medicine in Medical, Surgical and Critical Care Area (Me.Pre.C.C.), University of Palermo, Palermo, Italy., Dalfino L; Department of Precision-Regenerative Medicine and Jonic Area (DiMePRe-J), Intensive Care Unit, University Hospital Policlinico, Bari, Italy., Greco M; Department of Biomedical Sciences, Humanitas University, Milan, Italy.; Department of Anaesthesiology and Intensive Care, IRCCS Humanitas Research Hospital, Milan, Italy., Baroni S; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Laboratory and Hematological Sciences, Unit of Chemistry, Biochemistry and Molecular Biology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Esposito C; Department of Critical Care, Anaesthesia and Postoperative Unit, AO Ospedali dei Colli, Presidio Monaldi, Naples, Italy., Grieco DL; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Emergency Sciences, Anaesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Grinberg R; Shamir Medical Center, General Intensive Care Unit, Zriffin, Israel.; Gray School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel., Lombardi G; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Emergency Sciences, Anaesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Pota V; Department of Woman, Child, General and Specialized Surgery, Università degli studi della Campania L. Vanvitelli, Naples, Italy., Presti G; General Intensive Care Unit, University Hospital Policlinico Paolo Giaccone, Palermo, Italy.; Department of Precision Medicine in Medical, Surgical and Critical Care Area (Me.Pre.C.C.), University of Palermo, Palermo, Italy., Stufano M; Department of Precision-Regenerative Medicine and Jonic Area (DiMePRe-J), Intensive Care Unit, University Hospital Policlinico, Bari, Italy., Tanzarella ES; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Emergency Sciences, Anaesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Corcione A; Department of Critical Care, Anaesthesia and Postoperative Unit, AO Ospedali dei Colli, Presidio Monaldi, Naples, Italy., Pace C; Department of Woman, Child, General and Specialized Surgery, Università degli studi della Campania L. Vanvitelli, Naples, Italy., Sanguinetti M; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Laboratory and Hematological Sciences, Unit of Chemistry, Biochemistry and Molecular Biology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Bove T; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Emergency Sciences, Anaesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Urbani A; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Laboratory and Hematological Sciences, Unit of Chemistry, Biochemistry and Molecular Biology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Girardis M; Department of Anaesthesiology and Intensive Care, University Hospital of Modena, University of Modena and Reggio Emilia, Modena, Italy., Cecconi M; Department of Biomedical Sciences, Humanitas University, Milan, Italy.; Department of Anaesthesiology and Intensive Care, IRCCS Humanitas Research Hospital, Milan, Italy., Servillo G; Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy., Conti G; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Emergency Sciences, Anaesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Antonelli M; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Emergency Sciences, Anaesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. |
| Corporate Authors: | MICROINHALO study group |
| Source: | Intensive care medicine [Intensive Care Med] 2026 Jun; Vol. 52 (6), pp. 1235-1247. Date of Electronic Publication: 2026 Jun 02. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Multicenter Study |
| Journal Info: | Publisher: Springer Verlag Country of Publication: United States NLM ID: 7704851 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1238 (Electronic) Linking ISSN: 03424642 NLM ISO Abbreviation: Intensive Care Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42228008 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Personalized automatic management of tracheal cuff pressure and subglottic secretions drainage to prevent pneumonia in critically ill intubated patients. The MICROINHALO multicenter randomized controlled trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22De+Pascale+G%22">De Pascale G</searchLink>; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy. gennaro.depascalemd@gmail.com.; Department of Emergency Sciences, Anaesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. gennaro.depascalemd@gmail.com.<br /><searchLink fieldCode="AU" term="%22Cutuli+SL%22">Cutuli SL</searchLink>; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Emergency Sciences, Anaesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Vargas+M%22">Vargas M</searchLink>; Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Cortegiani+A%22">Cortegiani A</searchLink>; General Intensive Care Unit, University Hospital Policlinico Paolo Giaccone, Palermo, Italy.; Department of Precision Medicine in Medical, Surgical and Critical Care Area (Me.Pre.C.C.), University of Palermo, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Dalfino+L%22">Dalfino L</searchLink>; Department of Precision-Regenerative Medicine and Jonic Area (DiMePRe-J), Intensive Care Unit, University Hospital Policlinico, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Greco+M%22">Greco M</searchLink>; Department of Biomedical Sciences, Humanitas University, Milan, Italy.; Department of Anaesthesiology and Intensive Care, IRCCS Humanitas Research Hospital, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Baroni+S%22">Baroni S</searchLink>; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Laboratory and Hematological Sciences, Unit of Chemistry, Biochemistry and Molecular Biology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Esposito+C%22">Esposito C</searchLink>; Department of Critical Care, Anaesthesia and Postoperative Unit, AO Ospedali dei Colli, Presidio Monaldi, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Grieco+DL%22">Grieco DL</searchLink>; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Emergency Sciences, Anaesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Grinberg+R%22">Grinberg R</searchLink>; Shamir Medical Center, General Intensive Care Unit, Zriffin, Israel.; Gray School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Lombardi+G%22">Lombardi G</searchLink>; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Emergency Sciences, Anaesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Pota+V%22">Pota V</searchLink>; Department of Woman, Child, General and Specialized Surgery, Università degli studi della Campania L. Vanvitelli, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Presti+G%22">Presti G</searchLink>; General Intensive Care Unit, University Hospital Policlinico Paolo Giaccone, Palermo, Italy.; Department of Precision Medicine in Medical, Surgical and Critical Care Area (Me.Pre.C.C.), University of Palermo, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Stufano+M%22">Stufano M</searchLink>; Department of Precision-Regenerative Medicine and Jonic Area (DiMePRe-J), Intensive Care Unit, University Hospital Policlinico, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Tanzarella+ES%22">Tanzarella ES</searchLink>; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Emergency Sciences, Anaesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Corcione+A%22">Corcione A</searchLink>; Department of Critical Care, Anaesthesia and Postoperative Unit, AO Ospedali dei Colli, Presidio Monaldi, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Pace+C%22">Pace C</searchLink>; Department of Woman, Child, General and Specialized Surgery, Università degli studi della Campania L. Vanvitelli, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Sanguinetti+M%22">Sanguinetti M</searchLink>; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Laboratory and Hematological Sciences, Unit of Chemistry, Biochemistry and Molecular Biology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Bove+T%22">Bove T</searchLink>; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Emergency Sciences, Anaesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Urbani+A%22">Urbani A</searchLink>; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Laboratory and Hematological Sciences, Unit of Chemistry, Biochemistry and Molecular Biology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Girardis+M%22">Girardis M</searchLink>; Department of Anaesthesiology and Intensive Care, University Hospital of Modena, University of Modena and Reggio Emilia, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Cecconi+M%22">Cecconi M</searchLink>; Department of Biomedical Sciences, Humanitas University, Milan, Italy.; Department of Anaesthesiology and Intensive Care, IRCCS Humanitas Research Hospital, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Servillo+G%22">Servillo G</searchLink>; Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Conti+G%22">Conti G</searchLink>; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Emergency Sciences, Anaesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Antonelli+M%22">Antonelli M</searchLink>; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Emergency Sciences, Anaesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22MICROINHALO+study+group%22">MICROINHALO study group</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%227704851%22">Intensive care medicine</searchLink> [Intensive Care Med] 2026 Jun; Vol. 52 (6), pp. 1235-1247. <i>Date of Electronic Publication: </i>2026 Jun 02. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial; Multicenter Study – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7704851 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-1238 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203424642%22">03424642 </searchLink><i>NLM ISO Abbreviation: </i>Intensive Care Med <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42228008 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00134-026-08459-6 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1235 Titles: – TitleFull: Personalized automatic management of tracheal cuff pressure and subglottic secretions drainage to prevent pneumonia in critically ill intubated patients. The MICROINHALO multicenter randomized controlled trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: De Pascale G – PersonEntity: Name: NameFull: Cutuli SL – PersonEntity: Name: NameFull: Vargas M – PersonEntity: Name: NameFull: Cortegiani A – PersonEntity: Name: NameFull: Dalfino L – PersonEntity: Name: NameFull: Greco M – PersonEntity: Name: NameFull: Baroni S – PersonEntity: Name: NameFull: Esposito C – PersonEntity: Name: NameFull: Grieco DL – PersonEntity: Name: NameFull: Grinberg R – PersonEntity: Name: NameFull: Lombardi G – PersonEntity: Name: NameFull: Pota V – PersonEntity: Name: NameFull: Presti G – PersonEntity: Name: NameFull: Stufano M – PersonEntity: Name: NameFull: Tanzarella ES – PersonEntity: Name: NameFull: Corcione A – PersonEntity: Name: NameFull: Pace C – PersonEntity: Name: NameFull: Sanguinetti M – PersonEntity: Name: NameFull: Bove T – PersonEntity: Name: NameFull: Urbani A – PersonEntity: Name: NameFull: Girardis M – PersonEntity: Name: NameFull: Cecconi M – PersonEntity: Name: NameFull: Servillo G – PersonEntity: Name: NameFull: Conti G – PersonEntity: Name: NameFull: Antonelli M IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: 2026 Jun Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1432-1238 Numbering: – Type: volume Value: 52 – Type: issue Value: 6 Titles: – TitleFull: Intensive care medicine Type: main |
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